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Conference Paper: Detection of extracellular matrix degradation in intervertebral disc degeneration by diffusion magnetic resonance spectroscopy (DW-MRS)

TitleDetection of extracellular matrix degradation in intervertebral disc degeneration by diffusion magnetic resonance spectroscopy (DW-MRS)
Authors
Issue Date2014
PublisherISMRM-ESMRMB 2014.
Citation
The 2014 joint ISMRM-ESMRMB Annual Meeting, Milano, Italy, 10-16 May 2014. How to Cite?
AbstractThis study explored the capability of Diffusion Weighted Magnetic Resonance Spectroscopy (DW-MRS) to detect and characterize the ECM degradation during the early stage of IVDD. The apparent diffusion coefficient (ADC) of macromolecule resonances increased by approximately ten fold immediately after papain injection, and continued to increase in the following 5 days. The macromolecule T2 also had a slight increase during the ECM degradation and the macromolecule content is corrected by their corresponding T2 value. The macromolecule content, water T2 and ADC value showed a delayed change compared to the macromolecule ADCs. The macromolecule ADC is an early marker of the microstructural breakdown of PGs and collagen network in the disc NP during IVDD and hence DW-MRS is sensitive to detect disc degeneration at an early stage.
DescriptionTraditional Poster Session - Musculoskeleta: Spine: no. 1245
Persistent Identifierhttp://hdl.handle.net/10722/204141

 

DC FieldValueLanguage
dc.contributor.authorWang, AMen_US
dc.contributor.authorTsang, AHWen_US
dc.contributor.authorCao, Pen_US
dc.contributor.authorChan, Den_US
dc.contributor.authorWu, EXen_US
dc.date.accessioned2014-09-19T20:06:39Z-
dc.date.available2014-09-19T20:06:39Z-
dc.date.issued2014en_US
dc.identifier.citationThe 2014 joint ISMRM-ESMRMB Annual Meeting, Milano, Italy, 10-16 May 2014.en_US
dc.identifier.urihttp://hdl.handle.net/10722/204141-
dc.descriptionTraditional Poster Session - Musculoskeleta: Spine: no. 1245-
dc.description.abstractThis study explored the capability of Diffusion Weighted Magnetic Resonance Spectroscopy (DW-MRS) to detect and characterize the ECM degradation during the early stage of IVDD. The apparent diffusion coefficient (ADC) of macromolecule resonances increased by approximately ten fold immediately after papain injection, and continued to increase in the following 5 days. The macromolecule T2 also had a slight increase during the ECM degradation and the macromolecule content is corrected by their corresponding T2 value. The macromolecule content, water T2 and ADC value showed a delayed change compared to the macromolecule ADCs. The macromolecule ADC is an early marker of the microstructural breakdown of PGs and collagen network in the disc NP during IVDD and hence DW-MRS is sensitive to detect disc degeneration at an early stage.-
dc.languageengen_US
dc.publisherISMRM-ESMRMB 2014.-
dc.relation.ispartofISMRM-ESMRMB Annual Meeting 2014en_US
dc.titleDetection of extracellular matrix degradation in intervertebral disc degeneration by diffusion magnetic resonance spectroscopy (DW-MRS)en_US
dc.typeConference_Paperen_US
dc.identifier.emailTsang, AHW: ahwtsang@hku.hken_US
dc.identifier.emailCao, P: caopeng1@hku.hk-
dc.identifier.emailChan, D: chand@hku.hk-
dc.identifier.emailWu, EX: ewu1@hkucc.hku.hk-
dc.identifier.authorityChan, D=rp00540en_US
dc.description.naturelink_to_OA_fulltext-
dc.identifier.hkuros240608en_US
dc.publisher.placeItalyen_US

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