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Conference Paper: Absence of association between arterial stiffness and white matter hyperintensities in otherwise healthy hypertensive elderly Chinese

TitleAbsence of association between arterial stiffness and white matter hyperintensities in otherwise healthy hypertensive elderly Chinese
Authors
Issue Date2014
PublisherHong Kong Academy of Medicine Press. The Journal's web site is located at http://www.hkmj.org.hk
Citation
The 19th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong, China, 18 January 2014. In Hong Kong Medical Journal, 2014, v. 20 n. Suppl. 1, p. 51, abstract no. 83 How to Cite?
AbstractIntroduction: Arterial stiffness has been observed to be associated with white matter hyperintensities (WMH) in different populations. This study aimed to investigate whether such association exists in otherwise healthy hypertensive elderly Chinese. Methods: Degree of WMH has been assessed based on fluid-attenuated inversion recovery (FLAIR) magnetic resonance imaging using Fazekas white matter scale scores, and then dichotomised to compare with quartiles of brachial-ankle pulse wave velocity (BaPWV), a marker of arterial stiffness. Univariate and multivariate logistic regression models were used to determine the odds ratio (OR) for advanced WMH. Results: We studied a population of 252 otherwise healthy hypertensive Chinese over 65 years old, and advanced WMH was present in 53 (22.4%). In the highest BaPWV quartile, 22 (34.9%) subjects had advanced WMH. Significant association was observed between the highest quartile of BaPWV and advanced WMH when using the univariate logistic regression model. However, after controlling for demographic and arterial vascular risk factors (age, gender, body mass index, smoke history, grade of hypertension, duration of hypertension, total cholesterol, triglycerides, and high-density lipoprotein cholesterol), there was no statistically significant association (odds ratio = 2.101; 95% confidence interval, 0.781-5.649). Conclusion: This study did not provide any evidence for significant association between arterial stiffness and WMH. Fazekas white matter scale score may be too simple a tool to reveal the association and we shall pursuit more suitable resolution for further investigation.
Persistent Identifierhttp://hdl.handle.net/10722/203984
ISSN
2015 Impact Factor: 0.887
2015 SCImago Journal Rankings: 0.279

 

DC FieldValueLanguage
dc.contributor.authorZhang, Men_US
dc.contributor.authorXie, Ben_US
dc.contributor.authorMak, HKFen_US
dc.contributor.authorCheung, RTFen_US
dc.date.accessioned2014-09-19T19:48:25Z-
dc.date.available2014-09-19T19:48:25Z-
dc.date.issued2014en_US
dc.identifier.citationThe 19th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong, China, 18 January 2014. In Hong Kong Medical Journal, 2014, v. 20 n. Suppl. 1, p. 51, abstract no. 83en_US
dc.identifier.issn1024-2708-
dc.identifier.urihttp://hdl.handle.net/10722/203984-
dc.description.abstractIntroduction: Arterial stiffness has been observed to be associated with white matter hyperintensities (WMH) in different populations. This study aimed to investigate whether such association exists in otherwise healthy hypertensive elderly Chinese. Methods: Degree of WMH has been assessed based on fluid-attenuated inversion recovery (FLAIR) magnetic resonance imaging using Fazekas white matter scale scores, and then dichotomised to compare with quartiles of brachial-ankle pulse wave velocity (BaPWV), a marker of arterial stiffness. Univariate and multivariate logistic regression models were used to determine the odds ratio (OR) for advanced WMH. Results: We studied a population of 252 otherwise healthy hypertensive Chinese over 65 years old, and advanced WMH was present in 53 (22.4%). In the highest BaPWV quartile, 22 (34.9%) subjects had advanced WMH. Significant association was observed between the highest quartile of BaPWV and advanced WMH when using the univariate logistic regression model. However, after controlling for demographic and arterial vascular risk factors (age, gender, body mass index, smoke history, grade of hypertension, duration of hypertension, total cholesterol, triglycerides, and high-density lipoprotein cholesterol), there was no statistically significant association (odds ratio = 2.101; 95% confidence interval, 0.781-5.649). Conclusion: This study did not provide any evidence for significant association between arterial stiffness and WMH. Fazekas white matter scale score may be too simple a tool to reveal the association and we shall pursuit more suitable resolution for further investigation.-
dc.languageengen_US
dc.publisherHong Kong Academy of Medicine Press. The Journal's web site is located at http://www.hkmj.org.hk-
dc.relation.ispartofHong Kong Medical Journalen_US
dc.rightsHong Kong Medical Journal. Copyright © Hong Kong Academy of Medicine Press.-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleAbsence of association between arterial stiffness and white matter hyperintensities in otherwise healthy hypertensive elderly Chineseen_US
dc.typeConference_Paperen_US
dc.identifier.emailMak, HKF: makkf@hkucc.hku.hken_US
dc.identifier.emailCheung, RTF: rtcheung@hku.hken_US
dc.identifier.authorityMak, HKF=rp00533en_US
dc.identifier.authorityCheung, RTF=rp00434en_US
dc.description.naturepublished_or_final_version-
dc.identifier.hkuros236231en_US
dc.identifier.volume20en_US
dc.identifier.issueSuppl. 1en_US
dc.identifier.spage51, abstract no. 83en_US
dc.identifier.epage51, abstract no. 83en_US
dc.publisher.placeHong Kong-

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