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Conference Paper: The roles of Irx3 and Irx5 genes in inner ear sensorineural patterning

TitleThe roles of Irx3 and Irx5 genes in inner ear sensorineural patterning
Authors
Liu, YHui, CCSham, MH
Issue Date2014
Citation
The 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Hong Kong, 14 June 2014. In Program Booklet, 2014, p. 38, poster no. 48 How to Cite?
AbstractIrx3 and Irx5 are members of the Iroquois family TALE homeodomain transcription factors, which function as patterning genes in multiple developmental processes. In the developing limb bud, Irx3 and Irx5 are critical for establishing early AP polarity and digit specification. In the developing inner ear, we have found that Irx3/5 compound mutant displayed enlarged cochlear lumen, abnormal spiral ganglion, and fusion of inner ear sensory regions. These abnormal phenotypes suggest that Irx3 and Irx5 may have essential role in early inner …
DescriptionPoster Presentation - Theme 3: Development & stem cells
Persistent Identifierhttp://hdl.handle.net/10722/203836

 

DC FieldValueLanguage
dc.contributor.authorLiu, Yen_US
dc.contributor.authorHui, CCen_US
dc.contributor.authorSham, MHen_US
dc.date.accessioned2014-09-19T16:41:15Z-
dc.date.available2014-09-19T16:41:15Z-
dc.date.issued2014en_US
dc.identifier.citationThe 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Hong Kong, 14 June 2014. In Program Booklet, 2014, p. 38, poster no. 48en_US
dc.identifier.urihttp://hdl.handle.net/10722/203836-
dc.descriptionPoster Presentation - Theme 3: Development & stem cells-
dc.description.abstractIrx3 and Irx5 are members of the Iroquois family TALE homeodomain transcription factors, which function as patterning genes in multiple developmental processes. In the developing limb bud, Irx3 and Irx5 are critical for establishing early AP polarity and digit specification. In the developing inner ear, we have found that Irx3/5 compound mutant displayed enlarged cochlear lumen, abnormal spiral ganglion, and fusion of inner ear sensory regions. These abnormal phenotypes suggest that Irx3 and Irx5 may have essential role in early inner …-
dc.languageengen_US
dc.relation.ispartofHong Kong Inter-University 2014 Biochemistry Postgraduate Symposiumen_US
dc.titleThe roles of Irx3 and Irx5 genes in inner ear sensorineural patterningen_US
dc.typeConference_Paperen_US
dc.identifier.emailHui, CC: cchuilab@hku.hken_US
dc.identifier.emailSham, MH: mhsham@hku.hken_US
dc.identifier.authoritySham, MH=rp00380en_US
dc.description.naturepostprint-
dc.identifier.hkuros240243en_US
dc.identifier.spage38, poster no. 48-
dc.identifier.epage38, poster no. 48-

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