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Conference Paper: Sufu and Gli3 repressor mediate the temporal basal-to-apical progression of hair cell differentiation in mammalian cochleae
Title | Sufu and Gli3 repressor mediate the temporal basal-to-apical progression of hair cell differentiation in mammalian cochleae |
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Authors | |
Issue Date | 2014 |
Citation | The 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Hong Kong, 14 June 2014. In Program Booklet, 2014, p. 40, poster no. 52 How to Cite? |
Abstract | The Sonic Hedgehog pathway plays important roles in mammalian inner ear development. Mutations of Shh, Smo and Gli3 lead to severe defects in mouse inner ear morphogenesis. However, knockout of Gli2 does not affect inner ear morphology or cochlear hair cell differentiation, suggesting that the Gli repressor function may be required for Hedgehog signaling during inner ear development. Sufu is a negative regulator of Hedgehog signaling and it functions to repress Gli activator and enhance Gli repressor ... |
Description | Poster presentation - Theme 3: Development & stem cells |
Persistent Identifier | http://hdl.handle.net/10722/203833 |
DC Field | Value | Language |
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dc.contributor.author | Wang, B | en_US |
dc.contributor.author | Wong, EYM | en_US |
dc.contributor.author | Liu, Y | en_US |
dc.contributor.author | Hui, CC | en_US |
dc.contributor.author | Sham, MH | en_US |
dc.date.accessioned | 2014-09-19T16:41:15Z | - |
dc.date.available | 2014-09-19T16:41:15Z | - |
dc.date.issued | 2014 | en_US |
dc.identifier.citation | The 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Hong Kong, 14 June 2014. In Program Booklet, 2014, p. 40, poster no. 52 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/203833 | - |
dc.description | Poster presentation - Theme 3: Development & stem cells | - |
dc.description.abstract | The Sonic Hedgehog pathway plays important roles in mammalian inner ear development. Mutations of Shh, Smo and Gli3 lead to severe defects in mouse inner ear morphogenesis. However, knockout of Gli2 does not affect inner ear morphology or cochlear hair cell differentiation, suggesting that the Gli repressor function may be required for Hedgehog signaling during inner ear development. Sufu is a negative regulator of Hedgehog signaling and it functions to repress Gli activator and enhance Gli repressor ... | - |
dc.language | eng | en_US |
dc.relation.ispartof | Hong Kong Inter-University 2014 Biochemistry Postgraduate Symposium | en_US |
dc.title | Sufu and Gli3 repressor mediate the temporal basal-to-apical progression of hair cell differentiation in mammalian cochleae | en_US |
dc.type | Conference_Paper | en_US |
dc.identifier.email | Wong, EYM: elainewg@hku.hk | en_US |
dc.identifier.email | Liu, Y: ycliu12@hku.hk | en_US |
dc.identifier.email | Hui, CC: cchuilab@hku.hk | en_US |
dc.identifier.email | Sham, MH: mhsham@hku.hk | en_US |
dc.identifier.authority | Wong, EYM=rp01718 | en_US |
dc.identifier.authority | Sham, MH=rp00380 | en_US |
dc.description.nature | postprint | - |
dc.identifier.hkuros | 240240 | en_US |
dc.identifier.spage | 40, poster no. 52 | - |
dc.identifier.epage | 40, poster no. 52 | - |