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Conference Paper: Sufu and Gli3 repressor mediate the temporal basal-to-apical progression of hair cell differentiation in mammalian cochleae

TitleSufu and Gli3 repressor mediate the temporal basal-to-apical progression of hair cell differentiation in mammalian cochleae
Authors
Issue Date2014
Citation
The 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Hong Kong, 14 June 2014. In Program Booklet, 2014, p. 40, poster no. 52 How to Cite?
AbstractThe Sonic Hedgehog pathway plays important roles in mammalian inner ear development. Mutations of Shh, Smo and Gli3 lead to severe defects in mouse inner ear morphogenesis. However, knockout of Gli2 does not affect inner ear morphology or cochlear hair cell differentiation, suggesting that the Gli repressor function may be required for Hedgehog signaling during inner ear development. Sufu is a negative regulator of Hedgehog signaling and it functions to repress Gli activator and enhance Gli repressor ...
DescriptionPoster presentation - Theme 3: Development & stem cells
Persistent Identifierhttp://hdl.handle.net/10722/203833

 

DC FieldValueLanguage
dc.contributor.authorWang, Ben_US
dc.contributor.authorWong, EYMen_US
dc.contributor.authorLiu, Yen_US
dc.contributor.authorHui, CCen_US
dc.contributor.authorSham, MHen_US
dc.date.accessioned2014-09-19T16:41:15Z-
dc.date.available2014-09-19T16:41:15Z-
dc.date.issued2014en_US
dc.identifier.citationThe 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Hong Kong, 14 June 2014. In Program Booklet, 2014, p. 40, poster no. 52en_US
dc.identifier.urihttp://hdl.handle.net/10722/203833-
dc.descriptionPoster presentation - Theme 3: Development & stem cells-
dc.description.abstractThe Sonic Hedgehog pathway plays important roles in mammalian inner ear development. Mutations of Shh, Smo and Gli3 lead to severe defects in mouse inner ear morphogenesis. However, knockout of Gli2 does not affect inner ear morphology or cochlear hair cell differentiation, suggesting that the Gli repressor function may be required for Hedgehog signaling during inner ear development. Sufu is a negative regulator of Hedgehog signaling and it functions to repress Gli activator and enhance Gli repressor ...-
dc.languageengen_US
dc.relation.ispartofHong Kong Inter-University Biochemistry Postgraduate Symposiumen_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleSufu and Gli3 repressor mediate the temporal basal-to-apical progression of hair cell differentiation in mammalian cochleaeen_US
dc.typeConference_Paperen_US
dc.identifier.emailWong, EYM: elainewg@hku.hken_US
dc.identifier.emailLiu, Y: ycliu12@hku.hken_US
dc.identifier.emailHui, CC: cchuilab@hku.hken_US
dc.identifier.emailSham, MH: mhsham@hku.hken_US
dc.identifier.authorityWong, EYM=rp01718en_US
dc.identifier.authoritySham, MH=rp00380en_US
dc.description.naturepostprint-
dc.identifier.hkuros240240en_US
dc.identifier.spage40, poster no. 52-
dc.identifier.epage40, poster no. 52-

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