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Conference Paper: Assessment of Systemic Inflammation in Osteoarthritis Patients by Testing Fatty-acid-binding Protein 4 and Adiponectin in Plasma

TitleAssessment of Systemic Inflammation in Osteoarthritis Patients by Testing Fatty-acid-binding Protein 4 and Adiponectin in Plasma
Authors
Issue Date2013
PublisherHong Kong Academy of Medicine Press.
Citation
The 33rd Annual Congress of the Hong Kong Orthopaedic Association (HKOA), Hong Kong, China, 23-24 November 2013. In the Abstracts of the 33rd Annual Congress of the Hong Kong Orthopaedic Association (HKOA), 2013, p. 21, abstract no. 2.9 How to Cite?
AbstractIntroduction: Obesity not only increases risk of osteoarthritis (OA) in weight-bearing but also non–weight-bearing joints, indicating systemic mediators involved. It was recently reported that inflammation is involved in the pathogenesis of OA. Fatty-acid-binding protein 4 (FABP-4) has been described as a novel adipokine, playing a pro-inflammatory role in inflammatory pathways. Adiponectin has been widely reported with an anti-inflammatory function. This study aimed to evaluate the relationship of plasma levels of FABP4 and adiponectin and the presence of OA. Materials and Methods: For FABP4 concentration determination, a total of 231 Chinese subjects (77 males and 154 females) were recruited, including 141 OA cases and 90 community-based controls. Circulating levels of FABP4 and adiponectin were determined using enzyme-linked immunosorbent assay (AIS, HKU). Results: The mean (± standard deviation) FABP4 levels in OA patients (16.6 ± 15.5 ng/mL) were significantly higher than non-OA subjects (12.6 ± 10.1 ng/mL, p = 0.0453). Female subjects had significantly higher mean circulating levels of FABP4 than male counterparts both in case group (16.1 ± 14.9 ng/mL vs. 8.6 ± 7.3 ng/mL, p < 0.0001) and control group (17.1 ± 11.6 ng/mL vs. 7.9 ± 5.2 ng/mL, p < 0.0001). There were no significant differences of circulating levels of FABP4 neither between male cases and male controls (p = 0.765) nor female cases and female controls (p = 0.261). Discussion and Conclusion: Female subjects had significantly higher concentrations of FABP-4 in plasma.
DescriptionConference Theme: Defying the Aging Spine
Concurrent Free Papers 2: Basic Science / General Orthopaedics
Persistent Identifierhttp://hdl.handle.net/10722/203752

 

DC FieldValueLanguage
dc.contributor.authorLi, Ten_US
dc.contributor.authorYan, CHen_US
dc.contributor.authorXu, Aen_US
dc.contributor.authorSong, Yen_US
dc.contributor.authorChiu, PKYen_US
dc.date.accessioned2014-09-19T16:40:49Z-
dc.date.available2014-09-19T16:40:49Z-
dc.date.issued2013en_US
dc.identifier.citationThe 33rd Annual Congress of the Hong Kong Orthopaedic Association (HKOA), Hong Kong, China, 23-24 November 2013. In the Abstracts of the 33rd Annual Congress of the Hong Kong Orthopaedic Association (HKOA), 2013, p. 21, abstract no. 2.9en_US
dc.identifier.urihttp://hdl.handle.net/10722/203752-
dc.descriptionConference Theme: Defying the Aging Spine-
dc.descriptionConcurrent Free Papers 2: Basic Science / General Orthopaedics-
dc.description.abstractIntroduction: Obesity not only increases risk of osteoarthritis (OA) in weight-bearing but also non–weight-bearing joints, indicating systemic mediators involved. It was recently reported that inflammation is involved in the pathogenesis of OA. Fatty-acid-binding protein 4 (FABP-4) has been described as a novel adipokine, playing a pro-inflammatory role in inflammatory pathways. Adiponectin has been widely reported with an anti-inflammatory function. This study aimed to evaluate the relationship of plasma levels of FABP4 and adiponectin and the presence of OA. Materials and Methods: For FABP4 concentration determination, a total of 231 Chinese subjects (77 males and 154 females) were recruited, including 141 OA cases and 90 community-based controls. Circulating levels of FABP4 and adiponectin were determined using enzyme-linked immunosorbent assay (AIS, HKU). Results: The mean (± standard deviation) FABP4 levels in OA patients (16.6 ± 15.5 ng/mL) were significantly higher than non-OA subjects (12.6 ± 10.1 ng/mL, p = 0.0453). Female subjects had significantly higher mean circulating levels of FABP4 than male counterparts both in case group (16.1 ± 14.9 ng/mL vs. 8.6 ± 7.3 ng/mL, p < 0.0001) and control group (17.1 ± 11.6 ng/mL vs. 7.9 ± 5.2 ng/mL, p < 0.0001). There were no significant differences of circulating levels of FABP4 neither between male cases and male controls (p = 0.765) nor female cases and female controls (p = 0.261). Discussion and Conclusion: Female subjects had significantly higher concentrations of FABP-4 in plasma.-
dc.languageengen_US
dc.publisherHong Kong Academy of Medicine Press.-
dc.relation.ispartofAnnual Congress of the Hong Kong Orthopaedic Association (HKOA)en_US
dc.rightsAnnual Congress of the Hong Kong Orthopaedic Association (HKOA). Copyright © Hong Kong Academy of Medicine Press.-
dc.titleAssessment of Systemic Inflammation in Osteoarthritis Patients by Testing Fatty-acid-binding Protein 4 and Adiponectin in Plasmaen_US
dc.typeConference_Paperen_US
dc.identifier.emailYan, CH: yanchoi@hku.hken_US
dc.identifier.emailXu, A: amxu@hkucc.hku.hken_US
dc.identifier.emailSong, Y: songy@hku.hken_US
dc.identifier.emailChiu, PKY: pkychiu@hkucc.hku.hken_US
dc.identifier.authorityYan, CH=rp00303en_US
dc.identifier.authorityXu, A=rp00485en_US
dc.identifier.authoritySong, Y=rp00488en_US
dc.identifier.authorityChiu, PKY=rp00379en_US
dc.identifier.hkuros235763en_US
dc.identifier.hkuros240262-
dc.identifier.spage21, abstract no. 2.9en_US
dc.identifier.epage21, abstract no. 2.9en_US
dc.publisher.placeHong Kong, China-

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