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Conference Paper: Comparison of fatty-acid-binding protein 4 and adiponectin levels in infrapatellar fat pad and subcutaneous adipose tissue, synovial fluid and plasma in subjects with knee osteoarthritis

TitleComparison of fatty-acid-binding protein 4 and adiponectin levels in infrapatellar fat pad and subcutaneous adipose tissue, synovial fluid and plasma in subjects with knee osteoarthritis
Authors
Issue Date2013
Citation
The 33rd Annual Congress of the Hong Kong Orthopaedic Association (HKOA), Hong Kong, 23-24 November 2013. In Conference Abstracts, 2013, p. 21, abstract no. 2.8 How to Cite?
AbstractIntroduction: It was recently reported that inflammation is involved in the pathogenesis of osteoarthritis (OA). Fattyacid-binding protein 4 (FABP4) and adiponectin are both adipocyte-derived cytokines closely related with inflammation pathways. The FABP4 exhibits a pro-inflammatory property while adiponectin shows anti-inflammatory effect. The study aimed to assess the expression of FABP4 and adiponectin in paired blood and synovial fluid from OA patients, and to examine whether the infrapatellar fat pad (IPFP) from OA subjects would release FABP4 and adiponectin similar to that of donor-matched subcutaneous adipose tissue (ScAT). Materials and Methods: Plasma, synovial fluid, ScAT, and IPFP of 20 OA patients (4 males and 16 females) were collected during total knee arthroplasty. Levels of FABP4 and adiponectin were measured in plasma, synovial fluid, and fat conditioned media using ELISA (AIS, HKU). Results: Levels of FABP4 were significantly higher in IPFP media than ScAT (p = 0.015), while the same were significantly higher in synovial fluid than in plasma (p < 0.001). There were no significant differences of adiponectin levels between IPFP and ScAT media (p = 0.737). Plasma levels of adiponectin were significantly higher than synovial fluid (p < 0.001). Discussion and Conclusion: The OA patients exhibit an inflammatory state in local environment (IPFP and synovial fluid) compared with systemic environment (ScAT and plasma). The IPFP may play a key role in OA inflammation and may be an important resource of inflammatory mediators in synovial fluid.
DescriptionConference Theme: Defying the Aging Spine: Our Mission Continues
Concurrent Free Papers 2 - Basic Science/General Orthopaedics: no. 2.8
Persistent Identifierhttp://hdl.handle.net/10722/203751

 

DC FieldValueLanguage
dc.contributor.authorLi, Ten_US
dc.contributor.authorYan, CHen_US
dc.contributor.authorXu, AMen_US
dc.contributor.authorSong, YQen_US
dc.contributor.authorChiu, KYen_US
dc.date.accessioned2014-09-19T16:40:08Z-
dc.date.available2014-09-19T16:40:08Z-
dc.date.issued2013en_US
dc.identifier.citationThe 33rd Annual Congress of the Hong Kong Orthopaedic Association (HKOA), Hong Kong, 23-24 November 2013. In Conference Abstracts, 2013, p. 21, abstract no. 2.8en_US
dc.identifier.urihttp://hdl.handle.net/10722/203751-
dc.descriptionConference Theme: Defying the Aging Spine: Our Mission Continues-
dc.descriptionConcurrent Free Papers 2 - Basic Science/General Orthopaedics: no. 2.8-
dc.description.abstractIntroduction: It was recently reported that inflammation is involved in the pathogenesis of osteoarthritis (OA). Fattyacid-binding protein 4 (FABP4) and adiponectin are both adipocyte-derived cytokines closely related with inflammation pathways. The FABP4 exhibits a pro-inflammatory property while adiponectin shows anti-inflammatory effect. The study aimed to assess the expression of FABP4 and adiponectin in paired blood and synovial fluid from OA patients, and to examine whether the infrapatellar fat pad (IPFP) from OA subjects would release FABP4 and adiponectin similar to that of donor-matched subcutaneous adipose tissue (ScAT). Materials and Methods: Plasma, synovial fluid, ScAT, and IPFP of 20 OA patients (4 males and 16 females) were collected during total knee arthroplasty. Levels of FABP4 and adiponectin were measured in plasma, synovial fluid, and fat conditioned media using ELISA (AIS, HKU). Results: Levels of FABP4 were significantly higher in IPFP media than ScAT (p = 0.015), while the same were significantly higher in synovial fluid than in plasma (p < 0.001). There were no significant differences of adiponectin levels between IPFP and ScAT media (p = 0.737). Plasma levels of adiponectin were significantly higher than synovial fluid (p < 0.001). Discussion and Conclusion: The OA patients exhibit an inflammatory state in local environment (IPFP and synovial fluid) compared with systemic environment (ScAT and plasma). The IPFP may play a key role in OA inflammation and may be an important resource of inflammatory mediators in synovial fluid.-
dc.languageengen_US
dc.relation.ispartof33rd HKOA Annual Congress 2013en_US
dc.relation.ispartof2013 香港骨科醫學會第三十三屇週年會議-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleComparison of fatty-acid-binding protein 4 and adiponectin levels in infrapatellar fat pad and subcutaneous adipose tissue, synovial fluid and plasma in subjects with knee osteoarthritisen_US
dc.typeConference_Paperen_US
dc.identifier.emailYan, CH: yanchoi@hku.hken_US
dc.identifier.emailXu, AM: amxu@hkucc.hku.hken_US
dc.identifier.emailSong, YQ: songy@hku.hken_US
dc.identifier.emailChiu, KY: pkychiu@hkucc.hku.hken_US
dc.identifier.authorityYan, CH=rp00303en_US
dc.identifier.authorityXu, AM=rp00485en_US
dc.identifier.authoritySong, YQ=rp00488en_US
dc.identifier.authorityChiu, KY=rp00379en_US
dc.description.naturepostprint-
dc.identifier.hkuros235760en_US
dc.identifier.hkuros240259-
dc.identifier.spage21, abstract no. 2.8en_US
dc.identifier.epage21, abstract no. 2.8en_US

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