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Article: Comparison of serum anti-Mullerian hormone levels following hysterectomy and myomectomy for benign gynaecological conditions.

TitleComparison of serum anti-Mullerian hormone levels following hysterectomy and myomectomy for benign gynaecological conditions.
Authors
Issue Date2013
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ejogrb
Citation
European Journal of Obstetrics & Gynecology and Reproductive Biology, 2013, v. 171 n. 2, p. 368-371 How to Cite?
AbstractOBJECTIVE: To compare serum anti-Mullerian hormone (AMH) levels following hysterectomy and myomectomy. STUDY DESIGN: Prospective longitudinal observational study. Serum AMH, follicle stimulating hormone (FSH) and luteinizing hormone (LH) levels were measured pre-operatively (T1) and 2 days (T2) and 3 months (T3) following hysterectomy and myomectomy in 70 women aged 36-45 years. Hysterectomy (laparoscopy-assisted vaginal hysterectomy=10; total abdominal hysterectomy=25) with conservation of both ovaries for benign diseases of the uterus was performed in 35 women, and myomectomy (laparoscopy myomectomy=15; open myomectomy=20) was performed in another 35 women. The follow-up period was 3 months following surgery. The results were analysed using the t-test or one-way analysis of variance by repeated-measures ANOVA. RESULTS: Serum AMH in the hysterectomy group was 1.08+/-0.77 ng/ml at T1, 0.78+/-0.58 ng/ml at T2 and 0.81+/-0.58 ng/ml at T3; the level was significantly lower at T2 and T3 compared with T1. In the myomectomy group, the corresponding values were 1.54+/-0.95 ng/ml, 1.18+/-0.77 ng/ml and 1.50+/-0.58 ng/ml; serum AMH was significantly lower at T2 compared with T1, but the difference between T3 and T1 was not significant. There were no significant differences in serum FSH and LH in either group between these three time points. CONCLUSION: Serum AMH was significantly lower 2 days and 3 months following hysterectomy compared with the pre-operative level. Following myomectomy, serum AMH was significantly lower than the pre-operative level 2 days following the procedure, but was similar to the pre-operative level 3 months after surgery. Therefore, hysterectomy may have a more lasting adverse effect on ovarian reserve than myomectomy. A long-term study of AMH levels is needed.
Persistent Identifierhttp://hdl.handle.net/10722/203607
ISSN
2015 Impact Factor: 1.662
2015 SCImago Journal Rankings: 0.808
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWang, HYen_US
dc.contributor.authorQuan, Sen_US
dc.contributor.authorZhang, RLen_US
dc.contributor.authorYe, HYen_US
dc.contributor.authorBi, YLen_US
dc.contributor.authorJiang, ZMen_US
dc.contributor.authorNg, EHYen_US
dc.date.accessioned2014-09-19T15:32:29Z-
dc.date.available2014-09-19T15:32:29Z-
dc.date.issued2013en_US
dc.identifier.citationEuropean Journal of Obstetrics & Gynecology and Reproductive Biology, 2013, v. 171 n. 2, p. 368-371en_US
dc.identifier.issn0301-2115-
dc.identifier.urihttp://hdl.handle.net/10722/203607-
dc.description.abstractOBJECTIVE: To compare serum anti-Mullerian hormone (AMH) levels following hysterectomy and myomectomy. STUDY DESIGN: Prospective longitudinal observational study. Serum AMH, follicle stimulating hormone (FSH) and luteinizing hormone (LH) levels were measured pre-operatively (T1) and 2 days (T2) and 3 months (T3) following hysterectomy and myomectomy in 70 women aged 36-45 years. Hysterectomy (laparoscopy-assisted vaginal hysterectomy=10; total abdominal hysterectomy=25) with conservation of both ovaries for benign diseases of the uterus was performed in 35 women, and myomectomy (laparoscopy myomectomy=15; open myomectomy=20) was performed in another 35 women. The follow-up period was 3 months following surgery. The results were analysed using the t-test or one-way analysis of variance by repeated-measures ANOVA. RESULTS: Serum AMH in the hysterectomy group was 1.08+/-0.77 ng/ml at T1, 0.78+/-0.58 ng/ml at T2 and 0.81+/-0.58 ng/ml at T3; the level was significantly lower at T2 and T3 compared with T1. In the myomectomy group, the corresponding values were 1.54+/-0.95 ng/ml, 1.18+/-0.77 ng/ml and 1.50+/-0.58 ng/ml; serum AMH was significantly lower at T2 compared with T1, but the difference between T3 and T1 was not significant. There were no significant differences in serum FSH and LH in either group between these three time points. CONCLUSION: Serum AMH was significantly lower 2 days and 3 months following hysterectomy compared with the pre-operative level. Following myomectomy, serum AMH was significantly lower than the pre-operative level 2 days following the procedure, but was similar to the pre-operative level 3 months after surgery. Therefore, hysterectomy may have a more lasting adverse effect on ovarian reserve than myomectomy. A long-term study of AMH levels is needed.-
dc.languageengen_US
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ejogrb-
dc.relation.ispartofEuropean Journal of Obstetrics & Gynecology and Reproductive Biologyen_US
dc.rightsNOTICE: this is the author’s version of a work that was accepted for publication in European Journal of Obstetrics & Gynecology and Reproductive Biology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in European Journal of Obstetrics & Gynecology and Reproductive Biology, 2013, v. 171 n. 2, p. 368-371. DOI: 10.1016/j.ejogrb.2013.09.043-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshHysterectomy - adverse effects-
dc.subject.meshUterine Myomectomy - adverse effects-
dc.titleComparison of serum anti-Mullerian hormone levels following hysterectomy and myomectomy for benign gynaecological conditions.en_US
dc.typeArticleen_US
dc.identifier.emailNg, EHY: nghye@hku.hken_US
dc.identifier.authorityNg, EHY=rp00426en_US
dc.description.naturepostprint-
dc.identifier.doi10.1016/j.ejogrb.2013.09.043-
dc.identifier.pmid24172648-
dc.identifier.hkuros238662en_US
dc.identifier.volume171en_US
dc.identifier.spage368-
dc.identifier.isiWOS:000329599000035-
dc.publisher.placeIreland-

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