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Article: Curvature-modulated phase separation in lipid bilayer membranes

TitleCurvature-modulated phase separation in lipid bilayer membranes
Authors
Issue Date2006
Citation
Langmuir, 2006, v. 22, n. 11, p. 5095-5099 How to Cite?
AbstractCellular membranes exhibit a variety of controlled curvatures, with filopodia, microvilli, and mitotic cleavage furrows being only a few of many examples. Coupling between local curvature and chemical composition in membranes could provide a means of mechanically controlling the spatial organization of membrane components. Although this concept has surfaced repeatedly over the years, controlled experimental investigations have proven elusive. Here, we introduce an experimental platform, in which microfabricated surfaces impose specific curvature patterns onto lipid bilayers, that allows quantification of mechanochemical couplings in membranes. We find that, beyond a critical curvature value, membrane geometry governs the spatial ordering of phase-separated domain structures in membranes composed of cholesterol and phospholipids. The curvature-controlled ordering, a consequence of the distinct mechanical properties of the lipid phases, makes possible a determination of the bending rigidity difference between cholesterolrich and cholesterol-poor lipid domains. These observations point to a strong coupling between mechanical bending and chemical organization that should have wide-reaching consequences for biological membranes. Curvature-mediated patterning may also be useful in controlling complex fluids other than biomembranes. © 2006 American Chemical Society.
Persistent Identifierhttp://hdl.handle.net/10722/202191
ISSN
2015 Impact Factor: 3.993
2015 SCImago Journal Rankings: 1.750
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorParthasarathy, Raghuveer-
dc.contributor.authorYu, Chenghan-
dc.contributor.authorGroves, Jay T.-
dc.date.accessioned2014-08-22T02:57:47Z-
dc.date.available2014-08-22T02:57:47Z-
dc.date.issued2006-
dc.identifier.citationLangmuir, 2006, v. 22, n. 11, p. 5095-5099-
dc.identifier.issn0743-7463-
dc.identifier.urihttp://hdl.handle.net/10722/202191-
dc.description.abstractCellular membranes exhibit a variety of controlled curvatures, with filopodia, microvilli, and mitotic cleavage furrows being only a few of many examples. Coupling between local curvature and chemical composition in membranes could provide a means of mechanically controlling the spatial organization of membrane components. Although this concept has surfaced repeatedly over the years, controlled experimental investigations have proven elusive. Here, we introduce an experimental platform, in which microfabricated surfaces impose specific curvature patterns onto lipid bilayers, that allows quantification of mechanochemical couplings in membranes. We find that, beyond a critical curvature value, membrane geometry governs the spatial ordering of phase-separated domain structures in membranes composed of cholesterol and phospholipids. The curvature-controlled ordering, a consequence of the distinct mechanical properties of the lipid phases, makes possible a determination of the bending rigidity difference between cholesterolrich and cholesterol-poor lipid domains. These observations point to a strong coupling between mechanical bending and chemical organization that should have wide-reaching consequences for biological membranes. Curvature-mediated patterning may also be useful in controlling complex fluids other than biomembranes. © 2006 American Chemical Society.-
dc.languageeng-
dc.relation.ispartofLangmuir-
dc.titleCurvature-modulated phase separation in lipid bilayer membranes-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1021/la060390o-
dc.identifier.pmid16700599-
dc.identifier.scopuseid_2-s2.0-33745752076-
dc.identifier.volume22-
dc.identifier.issue11-
dc.identifier.spage5095-
dc.identifier.epage5099-
dc.identifier.isiWOS:000237593000034-

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