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Article: Genome-wide association analysis in East Asians identifies breast cancer susceptibility loci at 1q32.1, 5q14.3 and 15q26.1

TitleGenome-wide association analysis in East Asians identifies breast cancer susceptibility loci at 1q32.1, 5q14.3 and 15q26.1
Authors
Issue Date2014
Citation
Nature Genetics, 2014, v. 46 n. 8, p. 886-890 How to Cite?
AbstractIn a three-stage genome-wide association study among East Asian women including 22,780 cases and 24,181 controls, we identified 3 genetic loci newly associated with breast cancer risk, including rs4951011 at 1q32.1 (in intron 2 of the ZC3H11A gene; P = 8.82 x 10(-9)), rs10474352 at 5q14.3 (near the ARRDC3 gene; P = 1.67 x 10(-9)) and rs2290203 at 15q26.1 (in intron 14 of the PRC1 gene; P = 4.25 x 10(-8)). We replicated these associations in 16,003 cases and 41,335 controls of European ancestry (P = 0.030, 0.004 and 0.010, respectively). Data from the ENCODE Project suggest that variants rs4951011 and rs10474352 might be located in an enhancer region and transcription factor binding sites, respectively. This study provides additional insights into the genetics and biology of breast cancer.
Persistent Identifierhttp://hdl.handle.net/10722/201066
ISSN
2015 Impact Factor: 31.616
2015 SCImago Journal Rankings: 23.762
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorCai, Qen_US
dc.contributor.authorZhang, Ben_US
dc.contributor.authorSung, Hen_US
dc.contributor.authorLow, SKen_US
dc.contributor.authorKweon, SSen_US
dc.contributor.authorLu, Wen_US
dc.contributor.authorShi, Jen_US
dc.contributor.authorLong, Jen_US
dc.contributor.authorWen, Wen_US
dc.contributor.authorChoi, JYen_US
dc.contributor.authorNoh, DYen_US
dc.contributor.authorShen, CYen_US
dc.contributor.authorMatsuo, Ken_US
dc.contributor.authorTeo, SHen_US
dc.contributor.authorKim, MKen_US
dc.contributor.authorKhoo, USen_US
dc.contributor.authorIwasaki, Men_US
dc.contributor.authorHartman, Men_US
dc.contributor.authorTakahashi, Aen_US
dc.contributor.authorAshikawa, Ken_US
dc.contributor.authorMatsuda, Ken_US
dc.contributor.authorShin, MHen_US
dc.contributor.authorPark, MHen_US
dc.contributor.authorZheng, Yen_US
dc.contributor.authorXiang, YBen_US
dc.contributor.authorJi, BTen_US
dc.contributor.authorPark, SKen_US
dc.contributor.authorWu, PEen_US
dc.contributor.authorHsiung, CNen_US
dc.contributor.authorIto, Hen_US
dc.contributor.authorKasuga, Yen_US
dc.contributor.authorKang, Pen_US
dc.contributor.authorMariapun, Sen_US
dc.contributor.authorAhn, SHen_US
dc.contributor.authorKang, HSen_US
dc.contributor.authorChan, YKen_US
dc.contributor.authorMan, PSen_US
dc.contributor.authorIwata, Hen_US
dc.contributor.authorTsugane, Sen_US
dc.contributor.authorMiao, Hen_US
dc.contributor.authorLiao, Jen_US
dc.contributor.authorNakamura, Yen_US
dc.contributor.authorKubo, Men_US
dc.contributor.authorConsortium, DGen_US
dc.contributor.authorDelahanty, RJen_US
dc.contributor.authorZhang, Yen_US
dc.contributor.authorLi, Ben_US
dc.contributor.authorLi, Cen_US
dc.contributor.authorGao, YTen_US
dc.contributor.authorShu, XOen_US
dc.contributor.authorKang, Den_US
dc.contributor.authorZheng, Wen_US
dc.date.accessioned2014-08-21T07:12:02Z-
dc.date.available2014-08-21T07:12:02Z-
dc.date.issued2014en_US
dc.identifier.citationNature Genetics, 2014, v. 46 n. 8, p. 886-890en_US
dc.identifier.issn1061-4036en_US
dc.identifier.urihttp://hdl.handle.net/10722/201066-
dc.description.abstractIn a three-stage genome-wide association study among East Asian women including 22,780 cases and 24,181 controls, we identified 3 genetic loci newly associated with breast cancer risk, including rs4951011 at 1q32.1 (in intron 2 of the ZC3H11A gene; P = 8.82 x 10(-9)), rs10474352 at 5q14.3 (near the ARRDC3 gene; P = 1.67 x 10(-9)) and rs2290203 at 15q26.1 (in intron 14 of the PRC1 gene; P = 4.25 x 10(-8)). We replicated these associations in 16,003 cases and 41,335 controls of European ancestry (P = 0.030, 0.004 and 0.010, respectively). Data from the ENCODE Project suggest that variants rs4951011 and rs10474352 might be located in an enhancer region and transcription factor binding sites, respectively. This study provides additional insights into the genetics and biology of breast cancer.en_US
dc.languageengen_US
dc.relation.ispartofNature Geneticsen_US
dc.titleGenome-wide association analysis in East Asians identifies breast cancer susceptibility loci at 1q32.1, 5q14.3 and 15q26.1en_US
dc.typeArticleen_US
dc.identifier.emailKhoo, US: uskhoo@hku.hken_US
dc.identifier.emailChan, YK: ykchanc@hku.hken_US
dc.identifier.emailMan, PS: ellenman@hku.hken_US
dc.identifier.authorityKhoo, US=rp00362en_US
dc.identifier.authorityChan, YK=rp00453en_US
dc.identifier.doi10.1038/ng.3041en_US
dc.identifier.pmid25038754-
dc.identifier.hkuros234775en_US
dc.identifier.volume46en_US
dc.identifier.issue8en_US
dc.identifier.spage886en_US
dc.identifier.epage90en_US
dc.identifier.isiWOS:000339704400019-

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