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Conference Paper: Experience of pediatric heart transplantation in Hong Kong

TitleExperience of pediatric heart transplantation in Hong Kong
Authors
Issue Date2010
PublisherOxford University Press. The Journal's web site is located at http://eurheartjsupp.oxfordjournals.org
Citation
The 2010 International Congress of Cardiology, Hong Kong, China, 26-28 February 2010. In European Heart Journal Supplements, 2010, v. 12 n. suppl. A, p. S27, abstract no. P050 How to Cite?
AbstractOBJECTIVE: To describe the outcome and complications of the first three pediatric heart transplant patients in Hong Kong. METHOD: Three patients aged 6, 14, and 15 years who had undergone heart transplantation in 2009 were retrospectively reviewed. RESULTS: All patients suffered from end-staged heart failure related to idiopathic-dilated cardiomyopathy. Two patients (aged 6 and 15 years) are currently alive and are in NYHA class I. One patient had low cardiac output and intrathoracic bleeding on Day 1 after transplant requiring re-exploration and haemostasis. He developed complications of fungal septicemia, pancytopenia, necrotizing pancreatitis with pseudocyst formation, abdominal sepsis, tacrolimus-induced encephalopathy, and renal failure. He died of multi-organ failure 2 months after transplantation. The 6-year-old patient developed confusion and seizure on Day 10 after transplant. Magnetic resonance imaging brain showed features compatible with posterior reversible encephalopathy syndrome (PRES) due to cyclosporine neurotoxicity. She made a complete recovery without any neurological sequelae after stopping of cyclosporine. Both surviving patients had one episode of grade 2R acute cellular rejection treated with oral pulsed steroid. The patient who died had grade 1R acute cellular rejection. The immunosuppressant therapy consists of cyclosporine or tacrolimus, mycophenolate mofetil, and prednisolone. CONCLUSION: Heart transplantation is an option of treatment for end-staged heart failure in children. Achievement of successful outcome is possible in Hong Kong. We encountered uncommon complications of PRES and necrotizing pancreatitis in our patients.
DescriptionPoster Session
This journal suppl. entitled: Abstracts from the International Congress of Cardiology 2010
Persistent Identifierhttp://hdl.handle.net/10722/200372
ISSN
2015 Impact Factor: 0.455
2015 SCImago Journal Rankings: 0.152

 

DC FieldValueLanguage
dc.contributor.authorLun, KS-
dc.contributor.authorFan, K-
dc.contributor.authorYung, TC-
dc.contributor.authorWong, KT-
dc.contributor.authorCheung, YF-
dc.contributor.authorChau, AKT-
dc.contributor.authorCheng, LC-
dc.date.accessioned2014-08-19T04:56:52Z-
dc.date.available2014-08-19T04:56:52Z-
dc.date.issued2010-
dc.identifier.citationThe 2010 International Congress of Cardiology, Hong Kong, China, 26-28 February 2010. In European Heart Journal Supplements, 2010, v. 12 n. suppl. A, p. S27, abstract no. P050-
dc.identifier.issn1520-765X-
dc.identifier.urihttp://hdl.handle.net/10722/200372-
dc.descriptionPoster Session-
dc.descriptionThis journal suppl. entitled: Abstracts from the International Congress of Cardiology 2010-
dc.description.abstractOBJECTIVE: To describe the outcome and complications of the first three pediatric heart transplant patients in Hong Kong. METHOD: Three patients aged 6, 14, and 15 years who had undergone heart transplantation in 2009 were retrospectively reviewed. RESULTS: All patients suffered from end-staged heart failure related to idiopathic-dilated cardiomyopathy. Two patients (aged 6 and 15 years) are currently alive and are in NYHA class I. One patient had low cardiac output and intrathoracic bleeding on Day 1 after transplant requiring re-exploration and haemostasis. He developed complications of fungal septicemia, pancytopenia, necrotizing pancreatitis with pseudocyst formation, abdominal sepsis, tacrolimus-induced encephalopathy, and renal failure. He died of multi-organ failure 2 months after transplantation. The 6-year-old patient developed confusion and seizure on Day 10 after transplant. Magnetic resonance imaging brain showed features compatible with posterior reversible encephalopathy syndrome (PRES) due to cyclosporine neurotoxicity. She made a complete recovery without any neurological sequelae after stopping of cyclosporine. Both surviving patients had one episode of grade 2R acute cellular rejection treated with oral pulsed steroid. The patient who died had grade 1R acute cellular rejection. The immunosuppressant therapy consists of cyclosporine or tacrolimus, mycophenolate mofetil, and prednisolone. CONCLUSION: Heart transplantation is an option of treatment for end-staged heart failure in children. Achievement of successful outcome is possible in Hong Kong. We encountered uncommon complications of PRES and necrotizing pancreatitis in our patients.-
dc.languageeng-
dc.publisherOxford University Press. The Journal's web site is located at http://eurheartjsupp.oxfordjournals.org-
dc.relation.ispartofEuropean Heart Journal Supplements-
dc.rightsPre-print: Journal Title] ©: [year] [owner as specified on the article] Published by Oxford University Press [on behalf of xxxxxx]. All rights reserved. Pre-print (Once an article is published, preprint notice should be amended to): This is an electronic version of an article published in [include the complete citation information for the final version of the Article as published in the print edition of the Journal.] Post-print: This is a pre-copy-editing, author-produced PDF of an article accepted for publication in [insert journal title] following peer review. The definitive publisher-authenticated version [insert complete citation information here] is available online at: xxxxxxx [insert URL that the author will receive upon publication here].-
dc.titleExperience of pediatric heart transplantation in Hong Kong-
dc.typeConference_Paper-
dc.identifier.emailLun, KS: lunks@hku.hk-
dc.identifier.emailYung, TC: tcyung@hku.hk-
dc.identifier.emailWong, KT: ktwong07@hkucc.hku.hk-
dc.identifier.emailCheung, YF: xfcheung@hku.hk-
dc.identifier.emailChau, AKT: aktchau@hku.hk-
dc.identifier.emailCheng, LC: chenglc@hkucc.hku.hk-
dc.identifier.authorityCheung, YF=rp00382-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1093/eurheartj/sup049-
dc.identifier.hkuros170362-
dc.identifier.volume12-
dc.identifier.issuesuppl. A-
dc.identifier.spageS27, abstract no. P050-
dc.identifier.epageS27, abstract no. P050-
dc.publisher.placeUnited Kingdom-

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