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Article: Immunological mechanisms and clinical implications of regulatory T cell deficiency in a systemic autoimmune disorder: Roles of IL-2 versus IL-15

TitleImmunological mechanisms and clinical implications of regulatory T cell deficiency in a systemic autoimmune disorder: Roles of IL-2 versus IL-15
Authors
KeywordsIL-2
Dendritic cell
IL-15
Lupus
Regulatory T cell
Issue Date2008
Citation
European Journal of Immunology, 2008, v. 38, n. 6, p. 1664-1676 How to Cite?
AbstractRegulatory T cell deficiency is evident in patients with lupus, but the casual relationship and underlying mechanism leading to Treg deficiency are unclear. We analyzed the Treg profile, induction and functions of Treg in a lupus mouse model. A characteristic age-dependent biphasic change of Treg frequency was observed in the MRL/lpr mice, which developed a spontaneous lupus-like disease. After an early increase, Treg frequency in the peripheral lymphoid organs rapidly declined with age. Functionally, Treg from both young and old MRL/lpr mice were fully competent in suppressing the wild-type MRL/+ T effector cell (Teff) responses. Adoptive transfer of MRL/+ Treg markedly suppressed clinical disease in the MRL/lpr mice. We demonstrated that the reduced Treg frequency was a result of insufficient peripheral Treg expansion due to defective MRL/lpr Teff in IL-2 production, and the associated defects in dendritic cells, which could be fully restored by exogenous IL-2. In the absence of IL-2, MRL/lpr Teff but not MRL/lpr Treg were highly responsive to IL-15 and could expand rapidly due to enhanced IL-15R expression and IL-15 synthesis. These findings thus provide a clear causal relationship and immunological mechanism underlying Treg deficiency and systemic autoimmunity. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
Persistent Identifierhttp://hdl.handle.net/10722/199965
ISSN
2015 Impact Factor: 4.179
2015 SCImago Journal Rankings: 2.568
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorYang, Chuihong-
dc.contributor.authorTian, Lina-
dc.contributor.authorLing, Guangsheng-
dc.contributor.authorTrendell-Smith, Nigel Jeremy-
dc.contributor.authorMa, Liang-
dc.contributor.authorLo, Chikin-
dc.contributor.authorStott, David Ian-
dc.contributor.authorLiew, Fooyew-
dc.contributor.authorHuang, Fangping-
dc.date.accessioned2014-07-26T23:10:58Z-
dc.date.available2014-07-26T23:10:58Z-
dc.date.issued2008-
dc.identifier.citationEuropean Journal of Immunology, 2008, v. 38, n. 6, p. 1664-1676-
dc.identifier.issn0014-2980-
dc.identifier.urihttp://hdl.handle.net/10722/199965-
dc.description.abstractRegulatory T cell deficiency is evident in patients with lupus, but the casual relationship and underlying mechanism leading to Treg deficiency are unclear. We analyzed the Treg profile, induction and functions of Treg in a lupus mouse model. A characteristic age-dependent biphasic change of Treg frequency was observed in the MRL/lpr mice, which developed a spontaneous lupus-like disease. After an early increase, Treg frequency in the peripheral lymphoid organs rapidly declined with age. Functionally, Treg from both young and old MRL/lpr mice were fully competent in suppressing the wild-type MRL/+ T effector cell (Teff) responses. Adoptive transfer of MRL/+ Treg markedly suppressed clinical disease in the MRL/lpr mice. We demonstrated that the reduced Treg frequency was a result of insufficient peripheral Treg expansion due to defective MRL/lpr Teff in IL-2 production, and the associated defects in dendritic cells, which could be fully restored by exogenous IL-2. In the absence of IL-2, MRL/lpr Teff but not MRL/lpr Treg were highly responsive to IL-15 and could expand rapidly due to enhanced IL-15R expression and IL-15 synthesis. These findings thus provide a clear causal relationship and immunological mechanism underlying Treg deficiency and systemic autoimmunity. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.-
dc.languageeng-
dc.relation.ispartofEuropean Journal of Immunology-
dc.subjectIL-2-
dc.subjectDendritic cell-
dc.subjectIL-15-
dc.subjectLupus-
dc.subjectRegulatory T cell-
dc.titleImmunological mechanisms and clinical implications of regulatory T cell deficiency in a systemic autoimmune disorder: Roles of IL-2 versus IL-15-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/eji.200838190-
dc.identifier.pmid18465774-
dc.identifier.scopuseid_2-s2.0-49649098563-
dc.identifier.volume38-
dc.identifier.issue6-
dc.identifier.spage1664-
dc.identifier.epage1676-
dc.identifier.isiWOS:000256762400020-

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