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Conference Paper: Differential effects of antipsychotics on quality of life and functioning in Chinese patients with first-episode psychosis

TitleDifferential effects of antipsychotics on quality of life and functioning in Chinese patients with first-episode psychosis
Authors
Issue Date2014
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schres
Citation
The 4th Biennial Schizophrenia International Research Conference, Florence, Italy, 5-9 April 2014. In Schizophrenia Research, 2014, v. 153 suppl. 1, p. S282, poster no. M254 How to Cite?
AbstractBACKGROUND: Meta-analysis of RCTs suggested that patients with second generation antipsychotic treatment have higher functioning and quality of life than those with first generation antipsychotic treatment. However, findings from CATIE and CUtLASS raised doubt about their difference in real clinical settings, especially in patients with first-episode psychosis. We compared the effects of antipsychotics on quality of life and functioning in Chinese patients with first-episode psychosis. METHODS: A total of 285 patients were assessed with the Scale for the Assessment of Positive Symptoms (SAPS), the Scale for the Assessment of Negative Symptoms (SANS), the Udvalg for Kliniske Undersogelser (UKU), the Social and Occupational Functioning Assessment Scale (SOFAS), the Role Functioning Scale (RFS) and the Medical Outcomes Study Short Form 12-Item Health Survey (SF-12) after stabilization of mental condition. Difference between individual antipsychotic medications was investigated using ANOVA and post-hoc analysis. RESULTS: Significant differences were found between different antipsychotic medications in the mean of UKU neurological subscore, BARS total score, SOFAS score and SF-12 mental component summary score (MCS) score. Patients with haloperidol had higher mean UKU neurological subscore than patients with olanzapine or amisulpiride. Patients with risperidone had higher mean BARS total score than patients with olanzapine, amisulpiride or sulpiride. Patients with amisulpiride had higher mean MCS than patients with risperidone. DISCUSSION: Antipsychotics have differential effects on quality of life and functioning in patients with first episode psychosis. Future prospective study is warranted to investigate if patients with first episode psychosis will benefit from specific type of antipsychotics more than the others.
DescriptionThis journal suppl. entitled: Abstracts of the 4th Biennial Schizophrenia International Research Conference
Persistent Identifierhttp://hdl.handle.net/10722/197872
ISSN
2015 Impact Factor: 4.453
2015 SCImago Journal Rankings: 2.304

 

DC FieldValueLanguage
dc.contributor.authorLee, HMEen_US
dc.contributor.authorHui, CLMen_US
dc.contributor.authorChang, WCen_US
dc.contributor.authorChan, KWen_US
dc.contributor.authorChing, YNEen_US
dc.contributor.authorChen, EYHen_US
dc.date.accessioned2014-06-02T15:20:40Z-
dc.date.available2014-06-02T15:20:40Z-
dc.date.issued2014en_US
dc.identifier.citationThe 4th Biennial Schizophrenia International Research Conference, Florence, Italy, 5-9 April 2014. In Schizophrenia Research, 2014, v. 153 suppl. 1, p. S282, poster no. M254en_US
dc.identifier.issn0920-9964-
dc.identifier.urihttp://hdl.handle.net/10722/197872-
dc.descriptionThis journal suppl. entitled: Abstracts of the 4th Biennial Schizophrenia International Research Conference-
dc.description.abstractBACKGROUND: Meta-analysis of RCTs suggested that patients with second generation antipsychotic treatment have higher functioning and quality of life than those with first generation antipsychotic treatment. However, findings from CATIE and CUtLASS raised doubt about their difference in real clinical settings, especially in patients with first-episode psychosis. We compared the effects of antipsychotics on quality of life and functioning in Chinese patients with first-episode psychosis. METHODS: A total of 285 patients were assessed with the Scale for the Assessment of Positive Symptoms (SAPS), the Scale for the Assessment of Negative Symptoms (SANS), the Udvalg for Kliniske Undersogelser (UKU), the Social and Occupational Functioning Assessment Scale (SOFAS), the Role Functioning Scale (RFS) and the Medical Outcomes Study Short Form 12-Item Health Survey (SF-12) after stabilization of mental condition. Difference between individual antipsychotic medications was investigated using ANOVA and post-hoc analysis. RESULTS: Significant differences were found between different antipsychotic medications in the mean of UKU neurological subscore, BARS total score, SOFAS score and SF-12 mental component summary score (MCS) score. Patients with haloperidol had higher mean UKU neurological subscore than patients with olanzapine or amisulpiride. Patients with risperidone had higher mean BARS total score than patients with olanzapine, amisulpiride or sulpiride. Patients with amisulpiride had higher mean MCS than patients with risperidone. DISCUSSION: Antipsychotics have differential effects on quality of life and functioning in patients with first episode psychosis. Future prospective study is warranted to investigate if patients with first episode psychosis will benefit from specific type of antipsychotics more than the others.-
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/schres-
dc.relation.ispartofSchizophrenia Researchen_US
dc.titleDifferential effects of antipsychotics on quality of life and functioning in Chinese patients with first-episode psychosisen_US
dc.typeConference_Paperen_US
dc.identifier.emailLee, HME: edwinlhm@hku.hken_US
dc.identifier.emailHui, CLM: christyh@hkucc.hku.hken_US
dc.identifier.emailChang, WC: changwc@hku.hken_US
dc.identifier.emailChan, KW: kwsherry@hku.hken_US
dc.identifier.emailChing, YNE: eching@hku.hken_US
dc.identifier.emailChen, EYH: eyhchen@hku.hken_US
dc.identifier.authorityLee, HME=rp01575en_US
dc.identifier.authorityChang, WC=rp01465en_US
dc.identifier.authorityChan, KW=rp00539en_US
dc.identifier.authorityChen, EYH=rp00392en_US
dc.identifier.doi10.1016/S0920-9964(14)70804-7-
dc.identifier.hkuros229115en_US
dc.identifier.hkuros249090-
dc.identifier.volume153en_US
dc.identifier.issuesuppl. 1en_US
dc.identifier.spageS282, poster no. M254en_US
dc.identifier.epageS282, poster no. M254en_US
dc.publisher.placeNetherlands-

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