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Conference Paper: Visit-to-visit systolic blood pressure variability predicts all-cause and cardiovascular mortality after lacunar infarct

TitleVisit-to-visit systolic blood pressure variability predicts all-cause and cardiovascular mortality after lacunar infarct
Authors
Issue Date2014
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/ENE
Citation
The 14th Asian & Oceanian Congress of Neurology, Macao, China, 2-5 March 2014. In European Journal of Neurology, v. 21 n. 2, p. 319-325 How to Cite?
AbstractBACKGROUND AND PURPOSE: Both blood pressure (BP) and its variability (BPV) are established risk factors for development of atherosclerotic disease and are associated with an increased risk for cardiovascular and all-cause mortality. The prognostic implications of outpatient clinic visit-to-visit BPV amongst patients with lacunar infarction are nevertheless unknown. METHODS: The clinical outcome of 281 patients with lacunar infarction was prospectively followed up. The average BP and BPV, as determined by the standard deviation of the systolic and diastolic BP, were recorded during a mean 13 +/- 6 outpatient clinic visits. RESULTS: The mean age of the population was 70 +/- 10 years. After a mean 78 +/- 18 months follow-up, 65 patients died (23%), 31% (20/65) due to cardiovascular causes; 14% and 7% developed recurrent stroke and acute coronary syndrome. After adjusting for age, sex, mean systolic and diastolic BP, cardiovascular risk factors and comorbidities, patients with a systolic BPV of the third tertile had significantly higher risk of all-cause mortality [hazard ratio (HR) 1.97, 95% confidence interval (CI) 1.02-3.80, P = 0.04) and cardiovascular mortality (HR 7.64, 95% CI 1.65-35.41, P < 0.01) than those with systolic BPV of the first tertile. Nevertheless, systolic BPV did not predict recurrent stroke or acute coronary syndrome. Diastolic BPV did not predict various adverse clinical outcomes. CONCLUSIONS: Visit-to-visit systolic BPV predicts long-term all-cause and cardiovascular mortality after lacunar infarct, independent of conventional risk factors including average BP control.
Persistent Identifierhttp://hdl.handle.net/10722/195677
ISSN
2015 Impact Factor: 3.956
2015 SCImago Journal Rankings: 1.669
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLau, GKKen_US
dc.contributor.authorWong, YKen_US
dc.contributor.authorChang, RSKen_US
dc.contributor.authorTeo, KCen_US
dc.contributor.authorHon, SFKen_US
dc.contributor.authorChan, KHen_US
dc.contributor.authorWat, KLen_US
dc.contributor.authorCheung, RTFen_US
dc.contributor.authorLi, LSWen_US
dc.contributor.authorSiu, DCWen_US
dc.contributor.authorHo, SLen_US
dc.contributor.authorTse, HF-
dc.date.accessioned2014-03-07T04:24:38Z-
dc.date.available2014-03-07T04:24:38Z-
dc.date.issued2014en_US
dc.identifier.citationThe 14th Asian & Oceanian Congress of Neurology, Macao, China, 2-5 March 2014. In European Journal of Neurology, v. 21 n. 2, p. 319-325en_US
dc.identifier.issn1351-5101-
dc.identifier.urihttp://hdl.handle.net/10722/195677-
dc.description.abstractBACKGROUND AND PURPOSE: Both blood pressure (BP) and its variability (BPV) are established risk factors for development of atherosclerotic disease and are associated with an increased risk for cardiovascular and all-cause mortality. The prognostic implications of outpatient clinic visit-to-visit BPV amongst patients with lacunar infarction are nevertheless unknown. METHODS: The clinical outcome of 281 patients with lacunar infarction was prospectively followed up. The average BP and BPV, as determined by the standard deviation of the systolic and diastolic BP, were recorded during a mean 13 +/- 6 outpatient clinic visits. RESULTS: The mean age of the population was 70 +/- 10 years. After a mean 78 +/- 18 months follow-up, 65 patients died (23%), 31% (20/65) due to cardiovascular causes; 14% and 7% developed recurrent stroke and acute coronary syndrome. After adjusting for age, sex, mean systolic and diastolic BP, cardiovascular risk factors and comorbidities, patients with a systolic BPV of the third tertile had significantly higher risk of all-cause mortality [hazard ratio (HR) 1.97, 95% confidence interval (CI) 1.02-3.80, P = 0.04) and cardiovascular mortality (HR 7.64, 95% CI 1.65-35.41, P < 0.01) than those with systolic BPV of the first tertile. Nevertheless, systolic BPV did not predict recurrent stroke or acute coronary syndrome. Diastolic BPV did not predict various adverse clinical outcomes. CONCLUSIONS: Visit-to-visit systolic BPV predicts long-term all-cause and cardiovascular mortality after lacunar infarct, independent of conventional risk factors including average BP control.-
dc.languageengen_US
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/ENE-
dc.relation.ispartofEuropean Journal of Neurologyen_US
dc.rightsThe definitive version is available at www.blackwell-synergy.com-
dc.subject.meshBlood pressure variability-
dc.subject.meshLacunar infarct-
dc.subject.meshMortality-
dc.titleVisit-to-visit systolic blood pressure variability predicts all-cause and cardiovascular mortality after lacunar infarcten_US
dc.typeConference_Paperen_US
dc.identifier.emailLau, GKK: gkklau@hku.hken_US
dc.identifier.emailWong, YK: debbieyk@hku.hken_US
dc.identifier.emailChan, KH: koonho@hkucc.hku.hken_US
dc.identifier.emailCheung, RTF: rtcheung@hku.hken_US
dc.identifier.emailLi, LSW: lswli@hkucc.hku.hken_US
dc.identifier.emailSiu, DCW: cwdsiu@hkucc.hku.hken_US
dc.identifier.emailHo, SL: slho@hku.hken_US
dc.identifier.emailTse, HF: hftse@hkucc.hku.hk-
dc.identifier.authorityLau, GKK=rp01499en_US
dc.identifier.authorityChan, KH=rp00537en_US
dc.identifier.authorityCheung, RTF=rp00434en_US
dc.identifier.authoritySiu, DCW=rp00534en_US
dc.identifier.authorityHo, SL=rp00240en_US
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/ene.12310-
dc.identifier.pmid24267182-
dc.identifier.hkuros228204en_US
dc.identifier.hkuros228412-
dc.identifier.volume21en_US
dc.identifier.issue2en_US
dc.identifier.spage319en_US
dc.identifier.epage325en_US
dc.identifier.isiWOS:000329547200024-
dc.publisher.placeUnited Kingdom-

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