File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: dbPSHP: a database of recent positive selection across human populations

TitledbPSHP: a database of recent positive selection across human populations
Authors
Issue Date2014
PublisherOxford University Press. The Journal's web site is located at http://nar.oxfordjournals.org/
Citation
Nucleic Acids Research, 2014, v. 42 n. D1, p. D910-D916 How to Cite?
AbstractThe dbPSHP database (http://jjwanglab.org/dbpshp) aims to help researchers to efficiently identify, validate and visualize putative positively selected loci in human evolution and further discover the mechanism governing these natural selections. Recent evolution of human populations at the genomic level reflects the adaptations to the living environments, including climate change and availability and stability of nutrients. Many genetic regions under positive selection have been identified, which assist us to understand how natural selection has shaped population differences. Here, we manually collect recent positive selections in different human populations, consisting of 15,472 loci from 132 publications. We further compiled a database that used 15 statistical terms of different evolutionary attributes for single nucleotide variant sites from the HapMap 3 and 1000 Genomes Project to identify putative regions under positive selection. These attributes include variant allele/genotype properties, variant heterozygosity, within population diversity, long-range haplotypes, pairwise population differentiation and evolutionary conservation. We also provide interactive pages for visualization and annotation of different selective signals. The database is freely available to the public and will be frequently updated.
Persistent Identifierhttp://hdl.handle.net/10722/193161
ISSN
2015 Impact Factor: 9.202
2015 SCImago Journal Rankings: 7.458
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLi, J-
dc.contributor.authorWang, Y-
dc.contributor.authorXia, Z-
dc.contributor.authorWong, MP-
dc.contributor.authorSham, PC-
dc.contributor.authorWang, JJ-
dc.date.accessioned2013-12-20T02:25:45Z-
dc.date.available2013-12-20T02:25:45Z-
dc.date.issued2014-
dc.identifier.citationNucleic Acids Research, 2014, v. 42 n. D1, p. D910-D916-
dc.identifier.issn0305-1048-
dc.identifier.urihttp://hdl.handle.net/10722/193161-
dc.description.abstractThe dbPSHP database (http://jjwanglab.org/dbpshp) aims to help researchers to efficiently identify, validate and visualize putative positively selected loci in human evolution and further discover the mechanism governing these natural selections. Recent evolution of human populations at the genomic level reflects the adaptations to the living environments, including climate change and availability and stability of nutrients. Many genetic regions under positive selection have been identified, which assist us to understand how natural selection has shaped population differences. Here, we manually collect recent positive selections in different human populations, consisting of 15,472 loci from 132 publications. We further compiled a database that used 15 statistical terms of different evolutionary attributes for single nucleotide variant sites from the HapMap 3 and 1000 Genomes Project to identify putative regions under positive selection. These attributes include variant allele/genotype properties, variant heterozygosity, within population diversity, long-range haplotypes, pairwise population differentiation and evolutionary conservation. We also provide interactive pages for visualization and annotation of different selective signals. The database is freely available to the public and will be frequently updated.-
dc.languageeng-
dc.publisherOxford University Press. The Journal's web site is located at http://nar.oxfordjournals.org/-
dc.relation.ispartofNucleic Acids Research-
dc.subject.meshDatabases - Nucleic Acid-
dc.subject.meshSelection - Genetic-
dc.subject.meshGenetic Loci-
dc.subject.meshGenetic Variation-
dc.subject.meshHeterozygote-
dc.subject.meshHumans-
dc.subject.meshInternet-
dc.titledbPSHP: a database of recent positive selection across human populations-
dc.typeArticle-
dc.identifier.emailXia, Z: zhengyuan_xia@yahoo.com-
dc.identifier.emailWong, MP: mwpik@hku.hk-
dc.identifier.emailSham, PC: pcsham@hku.hk-
dc.identifier.emailWang, JJ: junwen@hku.hk-
dc.identifier.authorityXia, Z=rp00532-
dc.identifier.authorityWong, MP=rp00348-
dc.identifier.authoritySham, PC=rp00459-
dc.identifier.authorityWang, JJ=rp00280-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1093/nar/gkt1052-
dc.identifier.pmid24194603-
dc.identifier.pmcidPMC3965004-
dc.identifier.hkuros226972-
dc.identifier.hkuros235533-
dc.identifier.volume42-
dc.identifier.issueD1-
dc.identifier.spageD910-
dc.identifier.epageD916-
dc.identifier.isiWOS:000331139800133-
dc.publisher.placeUnited Kingdom-
dc.customcontrol.immutablesml 150427-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats