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Article: Susceptibility to myocardial ischemia reperfusion injury at early stage of type 1 diabetes in rats

TitleSusceptibility to myocardial ischemia reperfusion injury at early stage of type 1 diabetes in rats
Authors
KeywordsIschemia reperfusion injury
Diabetes mellitus
Infarct size
Issue Date2013
PublisherBioMed Central Ltd. The Journal's web site is located at http://www.cardiab.com/
Citation
Cardiovascular Diabetology, 2013, v. 12 n. 1, p. article no. 133 How to Cite?
AbstractLarge body of evidences accumulated in clinical and epidemiological studies indicate that hearts of diabetic subjects are more sensitive to ischemia reperfusion injury (IRI), which results in a higher rate of mortality at post-operation than that of non-diabetes. However, experimental results are equivocal and point to either increased or decreased susceptibility of the diabetic hearts to IRI, especially at the early stage of the disease. The present study was designed to test the hypothesis that the duration/severity of the indexed ischemia is a major determinant of the vulnerability to myocardial IRI at early stage of diabetes.
Persistent Identifierhttp://hdl.handle.net/10722/193160
ISSN
2015 Impact Factor: 4.534
2015 SCImago Journal Rankings: 1.757
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLi, Hen_US
dc.contributor.authorLiu, Zen_US
dc.contributor.authorWang, JJen_US
dc.contributor.authorWong, GTen_US
dc.contributor.authorCheung, CWen_US
dc.contributor.authorZhang, Len_US
dc.contributor.authorChen, Cen_US
dc.contributor.authorXia, Zen_US
dc.contributor.authorIrwin, MGen_US
dc.date.accessioned2013-12-20T02:25:44Z-
dc.date.available2013-12-20T02:25:44Z-
dc.date.issued2013en_US
dc.identifier.citationCardiovascular Diabetology, 2013, v. 12 n. 1, p. article no. 133en_US
dc.identifier.issn1475-2840en_US
dc.identifier.urihttp://hdl.handle.net/10722/193160-
dc.description.abstractLarge body of evidences accumulated in clinical and epidemiological studies indicate that hearts of diabetic subjects are more sensitive to ischemia reperfusion injury (IRI), which results in a higher rate of mortality at post-operation than that of non-diabetes. However, experimental results are equivocal and point to either increased or decreased susceptibility of the diabetic hearts to IRI, especially at the early stage of the disease. The present study was designed to test the hypothesis that the duration/severity of the indexed ischemia is a major determinant of the vulnerability to myocardial IRI at early stage of diabetes.-
dc.languageengen_US
dc.publisherBioMed Central Ltd. The Journal's web site is located at http://www.cardiab.com/-
dc.relation.ispartofCardiovascular Diabetologyen_US
dc.rightsCardiovascular Diabetology. Copyright © BioMed Central Ltd.-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectIschemia reperfusion injury-
dc.subjectDiabetes mellitus-
dc.subjectInfarct size-
dc.titleSusceptibility to myocardial ischemia reperfusion injury at early stage of type 1 diabetes in ratsen_US
dc.typeArticleen_US
dc.identifier.emailWang, JJ: junwen@hku.hken_US
dc.identifier.emailWong, GT: gordon@hku.hken_US
dc.identifier.emailXia, Z: zyxia@hku.hken_US
dc.identifier.emailIrwin, MG: mgirwin@hku.hk-
dc.identifier.authorityWang, JJ=rp00280en_US
dc.identifier.authorityWong, GT=rp00523en_US
dc.identifier.authorityXia, Z=rp00532en_US
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1186/1475-2840-12-133en_US
dc.identifier.pmid24041262-
dc.identifier.pmcidPMC3847499-
dc.identifier.scopuseid_2-s2.0-84883861274-
dc.identifier.hkuros226969en_US
dc.identifier.hkuros227645-
dc.identifier.volume12en_US
dc.identifier.issue1en_US
dc.identifier.spagearticle no. 133en_US
dc.identifier.epagearticle no. 133en_US
dc.identifier.isiWOS:000324515800001-
dc.publisher.placeUnited Kingdom-

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