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Article: Impacts of duration of untreated psychosis on cognition and negative symptoms in first-episode schizophrenia: A 3-year prospective follow-up study

TitleImpacts of duration of untreated psychosis on cognition and negative symptoms in first-episode schizophrenia: A 3-year prospective follow-up study
Authors
Issue Date2013
Citation
Psychological Medicine, 2013, v. 43 n. 9, p. 1883-1893 How to Cite?
AbstractBackground Cognitive impairment is a core feature of schizophrenia. Its relationship with duration of untreated psychosis (DUP), a potentially malleable prognostic factor, has been less studied, with inconsistent findings being observed in the literature. Previous research investigating such a relationship was mostly cross-sectional and none of those prospective studies had a follow-up duration beyond 2 years. Method A total of 93 Hong Kong Chinese aged 18 to 55 years presenting with first-episode schizophrenia-spectrum disorder were studied. DUP and pre-morbid adjustment were measured using a structured interview incorporating multiple sources of information. Psychopathological evaluation was administered at intake, after clinical stabilization of the first psychotic episode, and at 12, 24 and 36 months. Cognitive functions were measured at clinical stabilization, and at 12, 24 and 36 months. Results DUP exerted differential effects on various cognitive domains, with memory deficits being the most related to DUP even when potential confounders including pre-morbid adjustment and sex were adjusted. Prolonged DUP was associated with more severe impairment in visual memory at clinical stabilization and verbal memory at 24 and 36 months. Further, patients with a long DUP were found to have worse outcomes on negative symptoms at 36 months. The effects of DUP on verbal memory remained significant even when negative symptoms were taken into consideration. Conclusions Our findings provided further supportive evidence that delayed treatment to first-episode psychosis is associated with poorer cognitive and clinical outcomes. In addition, DUP may specifically affect memory function and its adverse impact on verbal memory may only become evident at a later stage of the recovery process. Copyright © Cambridge University Press 2012.
Persistent Identifierhttp://hdl.handle.net/10722/192733
ISSN
2015 Impact Factor: 5.491
2015 SCImago Journal Rankings: 2.843
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChang, WCen_US
dc.contributor.authorHui, CLMen_US
dc.contributor.authorTang, JYMen_US
dc.contributor.authorWong, GHYen_US
dc.contributor.authorChan, SKWen_US
dc.contributor.authorLee, EHMen_US
dc.contributor.authorChen, EYHen_US
dc.date.accessioned2013-11-20T05:00:03Z-
dc.date.available2013-11-20T05:00:03Z-
dc.date.issued2013en_US
dc.identifier.citationPsychological Medicine, 2013, v. 43 n. 9, p. 1883-1893en_US
dc.identifier.issn0033-2917en_US
dc.identifier.urihttp://hdl.handle.net/10722/192733-
dc.description.abstractBackground Cognitive impairment is a core feature of schizophrenia. Its relationship with duration of untreated psychosis (DUP), a potentially malleable prognostic factor, has been less studied, with inconsistent findings being observed in the literature. Previous research investigating such a relationship was mostly cross-sectional and none of those prospective studies had a follow-up duration beyond 2 years. Method A total of 93 Hong Kong Chinese aged 18 to 55 years presenting with first-episode schizophrenia-spectrum disorder were studied. DUP and pre-morbid adjustment were measured using a structured interview incorporating multiple sources of information. Psychopathological evaluation was administered at intake, after clinical stabilization of the first psychotic episode, and at 12, 24 and 36 months. Cognitive functions were measured at clinical stabilization, and at 12, 24 and 36 months. Results DUP exerted differential effects on various cognitive domains, with memory deficits being the most related to DUP even when potential confounders including pre-morbid adjustment and sex were adjusted. Prolonged DUP was associated with more severe impairment in visual memory at clinical stabilization and verbal memory at 24 and 36 months. Further, patients with a long DUP were found to have worse outcomes on negative symptoms at 36 months. The effects of DUP on verbal memory remained significant even when negative symptoms were taken into consideration. Conclusions Our findings provided further supportive evidence that delayed treatment to first-episode psychosis is associated with poorer cognitive and clinical outcomes. In addition, DUP may specifically affect memory function and its adverse impact on verbal memory may only become evident at a later stage of the recovery process. Copyright © Cambridge University Press 2012.en_US
dc.languageengen_US
dc.relation.ispartofPsychological Medicineen_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleImpacts of duration of untreated psychosis on cognition and negative symptoms in first-episode schizophrenia: A 3-year prospective follow-up studyen_US
dc.typeArticleen_US
dc.description.naturepublished_or_final_versionen_US
dc.identifier.doi10.1017/S0033291712002838en_US
dc.identifier.pmid23217676-
dc.identifier.scopuseid_2-s2.0-84881436998en_US
dc.identifier.hkuros222424-
dc.identifier.hkuros214636-
dc.identifier.hkuros224186-
dc.identifier.volume43en_US
dc.identifier.issue9en_US
dc.identifier.spage1883en_US
dc.identifier.epage1893en_US
dc.identifier.isiWOS:000322828600009-

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