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Book Chapter: The blood-follicle barrier (BFB) in disease and in ovarian function

TitleThe blood-follicle barrier (BFB) in disease and in ovarian function
Authors
Issue Date2013
PublisherLandes Bioscience and Springer Science
Citation
The blood-follicle barrier (BFB) in disease and in ovarian function. In Cheng, CY (Ed.), Biology and Regulation of Blood‑Tissue Barriers, p. 186-192. Austin and New York: Landes Bioscience and Springer Science, 2013 How to Cite?
AbstractThe blood-follicle barrier (BFB) is one of the blood-tissue barriers in mammalian body found in developing follicles in the ovary. The BFB, besides the tight junction (TJ)-permeability barrier of the endothelial cells in the microvessels that surround the developing follicle, is constituted and contributed significantly by the basement membrane of the developing follicle which alters its composition rapidly during follicle development. While the concept of the BFB and its ultrastructure were described more than six decades ago, fewer than 20 reports are found in the literature that were dedicated to investigate the biology, regulation, and function of the BFB either in health or in disease. Furthermore, detailed analysis of the adhesion protein complexes and the regulation of the junction dynamics at the BFB are still missing in the literature. The goal of this short chapter is to provide an update on this important blood-tissue barrier, it is obvious that future investigation is much needed in the field to understand this ultrastructure better in order to treat and better ovarian disorders including ovarian cancer.
Persistent Identifierhttp://hdl.handle.net/10722/190878
ISBN

 

DC FieldValueLanguage
dc.contributor.authorSiu, MKYen_US
dc.contributor.authorCheng, CYen_US
dc.date.accessioned2013-09-17T15:51:49Z-
dc.date.available2013-09-17T15:51:49Z-
dc.date.issued2013en_US
dc.identifier.citationThe blood-follicle barrier (BFB) in disease and in ovarian function. In Cheng, CY (Ed.), Biology and Regulation of Blood‑Tissue Barriers, p. 186-192. Austin and New York: Landes Bioscience and Springer Science, 2013en_US
dc.identifier.isbn9781461447108-
dc.identifier.urihttp://hdl.handle.net/10722/190878-
dc.description.abstractThe blood-follicle barrier (BFB) is one of the blood-tissue barriers in mammalian body found in developing follicles in the ovary. The BFB, besides the tight junction (TJ)-permeability barrier of the endothelial cells in the microvessels that surround the developing follicle, is constituted and contributed significantly by the basement membrane of the developing follicle which alters its composition rapidly during follicle development. While the concept of the BFB and its ultrastructure were described more than six decades ago, fewer than 20 reports are found in the literature that were dedicated to investigate the biology, regulation, and function of the BFB either in health or in disease. Furthermore, detailed analysis of the adhesion protein complexes and the regulation of the junction dynamics at the BFB are still missing in the literature. The goal of this short chapter is to provide an update on this important blood-tissue barrier, it is obvious that future investigation is much needed in the field to understand this ultrastructure better in order to treat and better ovarian disorders including ovarian cancer.-
dc.languageengen_US
dc.publisherLandes Bioscience and Springer Science-
dc.relation.ispartofBiology and Regulation of Blood‑Tissue Barriers-
dc.subject.meshBiological Transport-
dc.subject.meshEndothelium, Vascular - metabolism - pathology-
dc.subject.meshOvarian Follicle - blood supply - pathology - physiology-
dc.subject.meshOvarian Neoplasms - metabolism - pathology-
dc.subject.meshPolycystic Ovary Syndrome - blood supply - metabolism - pathology-
dc.titleThe blood-follicle barrier (BFB) in disease and in ovarian functionen_US
dc.typeBook_Chapteren_US
dc.identifier.emailSiu, MKY: mkysiu@hkucc.hku.hken_US
dc.identifier.authoritySiu, MKY=rp00275en_US
dc.identifier.doi10.1007/978-1-4614-4711-5_9-
dc.identifier.pmid23397625-
dc.identifier.scopuseid_2-s2.0-84875771363-
dc.identifier.hkuros222304en_US
dc.identifier.spage186-
dc.identifier.epage192-
dc.publisher.placeAustin and New York-

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