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Conference Paper: Evaluating The Role Of Serum Amh In Predicting Suboptimal Or Excessive Ovarian Response To Standard Dosing Regimen Of Ovarian Stimulation In In-Vitro Fertilisation Using Gnrh Agonist Long Protocol

TitleEvaluating The Role Of Serum Amh In Predicting Suboptimal Or Excessive Ovarian Response To Standard Dosing Regimen Of Ovarian Stimulation In In-Vitro Fertilisation Using Gnrh Agonist Long Protocol
Authors
Issue Date2011
PublisherOvarian Club.
Citation
The 2011 Meeting of the Ovarian Club, Barcelona, Spain, 3-6 November 2011. How to Cite?
AbstractIntroduction: Antral follicle count (AFC) is widely used for individualising gonadotrophin dosage in in-vitro fertilisation (IVF) treatment. This retrospective study tried to determine whether baseline serum anti-Mullerian hormone (AMH) measurement would offer any additional role in predicting suboptimal or excessive ovarian response among subjects classified to have normal ovarian reserve based on AFC. Methods: We reviewed 338 women undergoing the first IVF cycle using GnRH agonist long protocol who had baseline AFC of 6 to 14. Ovarian stimulation was initiated with gonadotrophin 300IU daily for two days followed by 150IU daily. Archival serum samples taken on the day before starting gonadotrophin were assayed for AMH. High responders were defined by retrieval of 15 or more oocytes or peak serum oestradiol >20000 pmol/l. Low responders were defined by retrieval of 5 or less oocytes. Results: Among the study cohort, 201 (59.5%), 77 (22.8%) and 73 (21.6%) women had optimal, low and high ovarian response respectively, and their respective median AMH concentrations differed significantly (22.5, 15.1 and 36.1 pmol/l). The area under the ROC curves for predicting high and low response were 0.740 and 0.688 respectively. At the best cut-off of 29 pmol/l, AMH has a sensitivity of 66% and specificity of 73% for predicting high response. At the best cut-off of 15 pmol/l, it has a sensitivity of 52% and specificity of 79% for predicting low response. Conclusion: Baseline serum AMH measurement offers a modest role for individualisation of gonadotrophin dosage in women with normal ovarian reserve based on AFC.
DescriptionConference Theme: The Oocyte: from Basic Research to Clinical Practice
Poster Presentation
Persistent Identifierhttp://hdl.handle.net/10722/190472

 

DC FieldValueLanguage
dc.contributor.authorLi, RHWen_US
dc.contributor.authorLee, VCYen_US
dc.contributor.authorLau, EYLen_US
dc.contributor.authorYeung, WSBen_US
dc.contributor.authorHo, PCen_US
dc.contributor.authorNg, EHYen_US
dc.date.accessioned2013-09-17T15:24:09Z-
dc.date.available2013-09-17T15:24:09Z-
dc.date.issued2011en_US
dc.identifier.citationThe 2011 Meeting of the Ovarian Club, Barcelona, Spain, 3-6 November 2011.en_US
dc.identifier.urihttp://hdl.handle.net/10722/190472-
dc.descriptionConference Theme: The Oocyte: from Basic Research to Clinical Practice-
dc.descriptionPoster Presentation-
dc.description.abstractIntroduction: Antral follicle count (AFC) is widely used for individualising gonadotrophin dosage in in-vitro fertilisation (IVF) treatment. This retrospective study tried to determine whether baseline serum anti-Mullerian hormone (AMH) measurement would offer any additional role in predicting suboptimal or excessive ovarian response among subjects classified to have normal ovarian reserve based on AFC. Methods: We reviewed 338 women undergoing the first IVF cycle using GnRH agonist long protocol who had baseline AFC of 6 to 14. Ovarian stimulation was initiated with gonadotrophin 300IU daily for two days followed by 150IU daily. Archival serum samples taken on the day before starting gonadotrophin were assayed for AMH. High responders were defined by retrieval of 15 or more oocytes or peak serum oestradiol >20000 pmol/l. Low responders were defined by retrieval of 5 or less oocytes. Results: Among the study cohort, 201 (59.5%), 77 (22.8%) and 73 (21.6%) women had optimal, low and high ovarian response respectively, and their respective median AMH concentrations differed significantly (22.5, 15.1 and 36.1 pmol/l). The area under the ROC curves for predicting high and low response were 0.740 and 0.688 respectively. At the best cut-off of 29 pmol/l, AMH has a sensitivity of 66% and specificity of 73% for predicting high response. At the best cut-off of 15 pmol/l, it has a sensitivity of 52% and specificity of 79% for predicting low response. Conclusion: Baseline serum AMH measurement offers a modest role for individualisation of gonadotrophin dosage in women with normal ovarian reserve based on AFC.-
dc.languageengen_US
dc.publisherOvarian Club.-
dc.relation.ispartofMeeting of the Ovarian Cluben_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleEvaluating The Role Of Serum Amh In Predicting Suboptimal Or Excessive Ovarian Response To Standard Dosing Regimen Of Ovarian Stimulation In In-Vitro Fertilisation Using Gnrh Agonist Long Protocolen_US
dc.typeConference_Paperen_US
dc.identifier.emailLi, RHW: raymondli@hku.hken_US
dc.identifier.emailLee, VCY: v200lee@hku.hken_US
dc.identifier.emailLau, EYL: eyllau@hkucc.hku.hken_US
dc.identifier.emailYeung, WSB: wsbyeung@hkucc.hku.hken_US
dc.identifier.emailHo, PC: pcho@hku.hken_US
dc.identifier.emailNg, EHY: nghye@hku.hken_US
dc.identifier.authorityLi, RHW=rp01649en_US
dc.identifier.authorityYeung, WSB=rp00331en_US
dc.identifier.authorityHo, PC=rp00325en_US
dc.identifier.authorityNg, EHY=rp00426en_US
dc.description.naturepublished_or_final_version-
dc.identifier.hkuros222196en_US

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