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Book Chapter: Epigenetic Regulation of EZH2 and Its Targeted MicroRNAs

TitleEpigenetic Regulation of EZH2 and Its Targeted MicroRNAs
Authors
Issue Date2013
PublisherSpringer
Citation
Epigenetic Regulation of EZH2 and Its Targeted MicroRNAs. In Sarkar, FH (Ed.), Epigenetics and Cancer, p. 33-61. Dordrecht; New York: Springer, 2013 How to Cite?
AbstractPolycomb group (PcG) proteins are transcriptional repressors which function to silence expressions of developmental and differentiation genes in eukaryotic cells. PcG proteins assemble into complexes termed Polycomb Repressive Complex (PRC) 1 and 2, and they elicit a cascade of epigenetic silencing events starting from trimethylation of the 27th lysine residue on histone H3 by the core PRC2 protein Enhancer of Zeste Homolog 2 (EZH2). In human cancers, PcG-mediated epigenetic silencing activity is increased as a result of upregulation of EZH2 and other PcG proteins. Consequentially, EZH2 is implicated in cancer development through epigenetic repression of tumor suppressor genes. MicroRNAs (miRNAs) are small, endogenously produced non-coding RNAs which function to negatively regulate the expression of their target mRNAs. MiRNA regulation is widespread and virtually over all cellular processes. In recent years, miRNAs have emerged as critical mediators in cancer pathogenesis. Remarkably, EZH2 can epigenetically silence miRNAs, while miRNAs also exert negative control over EZH2 expression, establishing a self-regulatory loop to reinforce their cancer specific roles. In this chapter, we review the current understanding of EZH2 and its regulated miRNAs in malignancies.
Persistent Identifierhttp://hdl.handle.net/10722/187489
ISBN

 

DC FieldValueLanguage
dc.contributor.authorAu, SLKen_US
dc.contributor.authorNg, IOLen_US
dc.contributor.authorWong, CMen_US
dc.date.accessioned2013-08-20T12:53:25Z-
dc.date.available2013-08-20T12:53:25Z-
dc.date.issued2013en_US
dc.identifier.citationEpigenetic Regulation of EZH2 and Its Targeted MicroRNAs. In Sarkar, FH (Ed.), Epigenetics and Cancer, p. 33-61. Dordrecht; New York: Springer, 2013en_US
dc.identifier.isbn9789400766112-
dc.identifier.urihttp://hdl.handle.net/10722/187489-
dc.description.abstractPolycomb group (PcG) proteins are transcriptional repressors which function to silence expressions of developmental and differentiation genes in eukaryotic cells. PcG proteins assemble into complexes termed Polycomb Repressive Complex (PRC) 1 and 2, and they elicit a cascade of epigenetic silencing events starting from trimethylation of the 27th lysine residue on histone H3 by the core PRC2 protein Enhancer of Zeste Homolog 2 (EZH2). In human cancers, PcG-mediated epigenetic silencing activity is increased as a result of upregulation of EZH2 and other PcG proteins. Consequentially, EZH2 is implicated in cancer development through epigenetic repression of tumor suppressor genes. MicroRNAs (miRNAs) are small, endogenously produced non-coding RNAs which function to negatively regulate the expression of their target mRNAs. MiRNA regulation is widespread and virtually over all cellular processes. In recent years, miRNAs have emerged as critical mediators in cancer pathogenesis. Remarkably, EZH2 can epigenetically silence miRNAs, while miRNAs also exert negative control over EZH2 expression, establishing a self-regulatory loop to reinforce their cancer specific roles. In this chapter, we review the current understanding of EZH2 and its regulated miRNAs in malignancies.-
dc.languageengen_US
dc.publisherSpringeren_US
dc.relation.ispartofEpigenetics and Canceren_US
dc.titleEpigenetic Regulation of EZH2 and Its Targeted MicroRNAsen_US
dc.typeBook_Chapteren_US
dc.identifier.emailAu, SLK: alkuen@hku.hken_US
dc.identifier.emailNg, IOL: iolng@hku.hken_US
dc.identifier.emailWong, CM: jackwong@pathology.hku.hken_US
dc.identifier.authorityNg, IOL=rp00335en_US
dc.identifier.doi10.1007/978-94-007-6612-9_3-
dc.identifier.hkuros217122en_US
dc.identifier.spage33en_US
dc.identifier.epage61en_US
dc.publisher.placeDordrecht; New York-

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