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Conference Paper: Serum Levels of Anti-Annexin II Antibodies Correlate with Disease Manifestations in Lupus Nephritis

TitleSerum Levels of Anti-Annexin II Antibodies Correlate with Disease Manifestations in Lupus Nephritis
Authors
Issue Date2013
PublisherThe International Society of Nephrology (ISN),.
Citation
World Congress of Nephrology (WCN), Hong Kong, China, 31 May-4 June 2013, abstract no. SU078 How to Cite?
AbstractINTRODUCTION AND AIMS: We have previously demonstrated that annexin II is a cross-reactive antigen on the surface of mesangial cells that mediate anti-dsDNA antibody binding and down-stream inflammatory processes. In this study, we investigated the relationship between serum anti-annexin II activity and clinical parameters of disease. METHODS: Serial serum samples from 23 patients with biopsy-proven severe proliferative lupus nephritis were included in this study. Serum samples from age- and sex-matched non-lupus glomerular disease and healthy individuals were used as controls. Serum anti-annexin II activity was determined by “in-house” ELISA and clinical parameters such as serum levels of IgG, anti-dsDNA antibodies, creatinine and C3 were measured by commercial assays. RESULTS: A total of 487 serum samples were obtained from patients with lupus nephritis, which comprised 97 and 390 samples from patients during active disease and remission respectively. Serum levels of anti-annexin II activity were significantly higher in patients with lupus nephritis compared with controls (P<0.01), and were higher in patients with active disease compared to remission in 15 out of 23 (65%) patients. Sero-positivity rate for anti-annexin II IgG was 20.3%, 5.3%, and 3.1% in patients with lupus nephritis, non-lupus glomerular diseases, and healthy controls respectively (P<0.001 for all). Anti-annexin II levels correlated with the level of anti-dsDNA antibodies (r=0.26, P<0.001), total IgG (r=0.45, P<0.0001), and serum creatinine (r=0.45, P<0.001), and inversely correlated with C3 level (r=-0.31, P<0.001). CONCLUSIONS: Our data demonstrate that IgG anti-annexin II titre correlates with serological and clinical markers of disease activity in lupus nephritis.
DescriptionConferenc theme: Sustainability and Diversity
Moderated Poster Session: Renal Pathology, Experimental Pathology, Including Immune and Inflammatory Mechanisms
Persistent Identifierhttp://hdl.handle.net/10722/186820

 

DC FieldValueLanguage
dc.contributor.authorCheung, KFen_US
dc.contributor.authorYung, SSYen_US
dc.contributor.authorYim, ASYen_US
dc.contributor.authorChan, DTMen_US
dc.date.accessioned2013-08-20T12:21:09Z-
dc.date.available2013-08-20T12:21:09Z-
dc.date.issued2013-
dc.identifier.citationWorld Congress of Nephrology (WCN), Hong Kong, China, 31 May-4 June 2013, abstract no. SU078en_US
dc.identifier.urihttp://hdl.handle.net/10722/186820-
dc.descriptionConferenc theme: Sustainability and Diversity-
dc.descriptionModerated Poster Session: Renal Pathology, Experimental Pathology, Including Immune and Inflammatory Mechanisms-
dc.description.abstractINTRODUCTION AND AIMS: We have previously demonstrated that annexin II is a cross-reactive antigen on the surface of mesangial cells that mediate anti-dsDNA antibody binding and down-stream inflammatory processes. In this study, we investigated the relationship between serum anti-annexin II activity and clinical parameters of disease. METHODS: Serial serum samples from 23 patients with biopsy-proven severe proliferative lupus nephritis were included in this study. Serum samples from age- and sex-matched non-lupus glomerular disease and healthy individuals were used as controls. Serum anti-annexin II activity was determined by “in-house” ELISA and clinical parameters such as serum levels of IgG, anti-dsDNA antibodies, creatinine and C3 were measured by commercial assays. RESULTS: A total of 487 serum samples were obtained from patients with lupus nephritis, which comprised 97 and 390 samples from patients during active disease and remission respectively. Serum levels of anti-annexin II activity were significantly higher in patients with lupus nephritis compared with controls (P<0.01), and were higher in patients with active disease compared to remission in 15 out of 23 (65%) patients. Sero-positivity rate for anti-annexin II IgG was 20.3%, 5.3%, and 3.1% in patients with lupus nephritis, non-lupus glomerular diseases, and healthy controls respectively (P<0.001 for all). Anti-annexin II levels correlated with the level of anti-dsDNA antibodies (r=0.26, P<0.001), total IgG (r=0.45, P<0.0001), and serum creatinine (r=0.45, P<0.001), and inversely correlated with C3 level (r=-0.31, P<0.001). CONCLUSIONS: Our data demonstrate that IgG anti-annexin II titre correlates with serological and clinical markers of disease activity in lupus nephritis.-
dc.languageengen_US
dc.publisherThe International Society of Nephrology (ISN),.-
dc.relation.ispartofWorld Congress of Nephrology (WCN)en_US
dc.titleSerum Levels of Anti-Annexin II Antibodies Correlate with Disease Manifestations in Lupus Nephritisen_US
dc.typeConference_Paperen_US
dc.identifier.emailCheung, KF: skfc819@hku.hken_US
dc.identifier.emailYung, SSY: ssyyung@hku.hken_US
dc.identifier.emailYim, ASY: anndyim@hku.hken_US
dc.identifier.emailChan, DTM: dtmchan@hku.hken_US
dc.identifier.authorityYung, SSY=rp00455en_US
dc.identifier.authorityChan, DTM=rp00394en_US
dc.identifier.hkuros218221en_US
dc.publisher.placeBelgium-

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