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Conference Paper: NIR-emissive Alkynylplatinum(II) Terpyridyl Complex as a turn-on selective probe for heparin quantification by induced helical self-assembly behaviour

TitleNIR-emissive Alkynylplatinum(II) Terpyridyl Complex as a turn-on selective probe for heparin quantification by induced helical self-assembly behaviour
Authors
Issue Date2013
PublisherCentre for Functional Photonics, City University of Hong Kong.
Citation
The 2013 International Workshop on Photonics of Functional Nanomaterials, Hong Kong, 6-9 May 2013. In Abstracts Book, 2013, p. 67, abstarct no. 4 How to Cite?
AbstractThe extent of self-assembly viametal–metal and π-π stacking interactions, induced by the polyanionic biopolymers, enables the class of alkynylplatinum(II) terpyridyl complexes to be applicable for the sensing of important biomacromolecules through the monitoring of spectral changes. Strong demand arises for the design of selective and practical detection techniques for the quantification of heparin, a highly negative-charged polysaccharidethat can function as anticoagulant, due to the prevention of hemorrhagic complications upon overdose usage.Aconvenient sensing protocol for the detection of UFH and LMWH, two common forms of heparins in clinical use, in buffer and biological medium has been demonstrated with the spectral changes associated with the induced self-assembly of a NIR-emissive platinum(II) complex. The detection range has been demonstrated to cover clinical dosage levels and the structurally similar analogues can be effectively differentiated based on their anionic charge density and the formation of supramolecular helical assembly of the platinum(II) complex with them ...
Persistent Identifierhttp://hdl.handle.net/10722/186664

 

DC FieldValueLanguage
dc.contributor.authorYeung, MCLen_US
dc.contributor.authorYam, VWWen_US
dc.date.accessioned2013-08-20T12:16:26Z-
dc.date.available2013-08-20T12:16:26Z-
dc.date.issued2013en_US
dc.identifier.citationThe 2013 International Workshop on Photonics of Functional Nanomaterials, Hong Kong, 6-9 May 2013. In Abstracts Book, 2013, p. 67, abstarct no. 4en_US
dc.identifier.urihttp://hdl.handle.net/10722/186664-
dc.description.abstractThe extent of self-assembly viametal–metal and π-π stacking interactions, induced by the polyanionic biopolymers, enables the class of alkynylplatinum(II) terpyridyl complexes to be applicable for the sensing of important biomacromolecules through the monitoring of spectral changes. Strong demand arises for the design of selective and practical detection techniques for the quantification of heparin, a highly negative-charged polysaccharidethat can function as anticoagulant, due to the prevention of hemorrhagic complications upon overdose usage.Aconvenient sensing protocol for the detection of UFH and LMWH, two common forms of heparins in clinical use, in buffer and biological medium has been demonstrated with the spectral changes associated with the induced self-assembly of a NIR-emissive platinum(II) complex. The detection range has been demonstrated to cover clinical dosage levels and the structurally similar analogues can be effectively differentiated based on their anionic charge density and the formation of supramolecular helical assembly of the platinum(II) complex with them ...-
dc.languageengen_US
dc.publisherCentre for Functional Photonics, City University of Hong Kong.-
dc.relation.ispartof2013 International Workshop on Photonics of Functional Nanomaterials Abstracts Booken_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleNIR-emissive Alkynylplatinum(II) Terpyridyl Complex as a turn-on selective probe for heparin quantification by induced helical self-assembly behaviouren_US
dc.typeConference_Paperen_US
dc.identifier.emailYam, VWW: wwyam@hku.hken_US
dc.identifier.authorityYam, VWW=rp00822en_US
dc.description.naturepostprint-
dc.identifier.hkuros219636en_US
dc.identifier.spage67en_US
dc.identifier.epage67en_US
dc.publisher.placeHong Kongen_US
dc.customcontrol.immutablesml 130912-

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