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Article: Up-regulation of GITRL on dendritic cells by WGP improves anti-tumor immunity in murine Lewis lung carcinoma
Title | Up-regulation of GITRL on dendritic cells by WGP improves anti-tumor immunity in murine Lewis lung carcinoma |
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Authors | |
Issue Date | 2012 |
Publisher | Public Library of Science. The Journal's web site is located at http://www.plosone.org/home.action |
Citation | PLoS One, 2012, v. 7 n. 10, p. e46936 How to Cite? |
Abstract | Background
β-Glucans have been shown to function as a potent immunomodulator to stimulate innate and adaptive immune responses, which contributes to their anti-tumor property. However, their mechanisms of action are still elusive. Glucocorticoid-induced TNF receptor ligand (GITRL), a member of the TNF superfamily, binds to its receptor, GITR, on both effector and regulatory T cells, generates a positive co-stimulatory signal implicated in a wide range of T cell functions, which is important for the development of immune responses.
Methodology/Principal Findings
In this study, we found that whole β-glucan particles (WGPs) could activate dendritic cells (DCs) via dectin-1 receptor, and increase the expression of GITRL on DCs in vitro and in vivo. Furthermore, we demonstrated that the increased GITRL on DCs could impair the regulartory T cell (Treg)-mediated suppression and enhance effector T cell proliferation in a GITR/GITRL dependent way. In tumor models, DCs with high levels of GITRL were of great potential to prime cytotoxic T lymphocyte (CTL) responses and down-regulate the suppressive activity of Treg cells, thereby leading to the delayed tumor progression.
Conclusions/Significance
These findings suggest that particulate β-glucans can be used as an immunomodulator to stimulate potent T cell-mediated adaptive immunity while down-regulate suppressive immune activity via GITR/GITRL interaction, leading to a more efficient defense mechanism against tumor development. |
Persistent Identifier | http://hdl.handle.net/10722/186440 |
ISSN | 2023 Impact Factor: 2.9 2023 SCImago Journal Rankings: 0.839 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Tian, J | - |
dc.contributor.author | Ma, J | - |
dc.contributor.author | Ma, K | - |
dc.contributor.author | Ma, B | - |
dc.contributor.author | Tang, X | - |
dc.contributor.author | Baidoo, SE | - |
dc.contributor.author | Tong, J | - |
dc.contributor.author | Yan, J | - |
dc.contributor.author | Lu, L | - |
dc.contributor.author | Xu, H | - |
dc.contributor.author | Wang, S | - |
dc.date.accessioned | 2013-08-20T12:08:59Z | - |
dc.date.available | 2013-08-20T12:08:59Z | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | PLoS One, 2012, v. 7 n. 10, p. e46936 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | http://hdl.handle.net/10722/186440 | - |
dc.description.abstract | Background β-Glucans have been shown to function as a potent immunomodulator to stimulate innate and adaptive immune responses, which contributes to their anti-tumor property. However, their mechanisms of action are still elusive. Glucocorticoid-induced TNF receptor ligand (GITRL), a member of the TNF superfamily, binds to its receptor, GITR, on both effector and regulatory T cells, generates a positive co-stimulatory signal implicated in a wide range of T cell functions, which is important for the development of immune responses. Methodology/Principal Findings In this study, we found that whole β-glucan particles (WGPs) could activate dendritic cells (DCs) via dectin-1 receptor, and increase the expression of GITRL on DCs in vitro and in vivo. Furthermore, we demonstrated that the increased GITRL on DCs could impair the regulartory T cell (Treg)-mediated suppression and enhance effector T cell proliferation in a GITR/GITRL dependent way. In tumor models, DCs with high levels of GITRL were of great potential to prime cytotoxic T lymphocyte (CTL) responses and down-regulate the suppressive activity of Treg cells, thereby leading to the delayed tumor progression. Conclusions/Significance These findings suggest that particulate β-glucans can be used as an immunomodulator to stimulate potent T cell-mediated adaptive immunity while down-regulate suppressive immune activity via GITR/GITRL interaction, leading to a more efficient defense mechanism against tumor development. | - |
dc.language | eng | - |
dc.publisher | Public Library of Science. The Journal's web site is located at http://www.plosone.org/home.action | - |
dc.relation.ispartof | PLoS ONE | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.title | Up-regulation of GITRL on dendritic cells by WGP improves anti-tumor immunity in murine Lewis lung carcinoma | - |
dc.type | Article | - |
dc.identifier.email | Lu, L: liweilu@hkucc.hku.hk | - |
dc.identifier.authority | Lu, L=rp00477 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1371/journal.pone.0046936 | - |
dc.identifier.pmcid | PMC3471954 | - |
dc.identifier.scopus | eid_2-s2.0-84867546608 | - |
dc.identifier.hkuros | 218876 | - |
dc.identifier.volume | 7 | - |
dc.identifier.issue | 10 | - |
dc.identifier.spage | e46936 | - |
dc.identifier.epage | e46936 | - |
dc.identifier.isi | WOS:000309995100048 | - |
dc.publisher.place | United States | - |
dc.identifier.issnl | 1932-6203 | - |