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Conference Paper: Role of HLA-DP polymorphisms on chronicity and disease activity of hepatitis B infection in the Chinese

TitleRole of HLA-DP polymorphisms on chronicity and disease activity of hepatitis B infection in the Chinese
Authors
KeywordsMedical sciences
Endocrinology
Issue Date2013
PublisherSpringer New York LLC. The Journal's web site is located at http://www.springer.com/west/home/medicine?SGWID=4-10054-70-173733513-0
Citation
The 2013 Asian Pacific Association for the Study of the Liver (Liver Week 2013), Singapore, 6-10 June 2013. In Hepatology International, 2013, v. 7 n. 1 suppl., p. S192, abstract no. 634 How to Cite?
AbstractBACKGROUND/AIMS: The association between HLA-DP single nucleotide polymorphisms (SNPs) and chronic hepatitis B virus (HBV) infection varies between different populations. We aimed to study the association between HLA-DP SNPs and HBV infection and disease activity in the Chinese population of Hong Kong. METHODS: We genotyped SNPs rs3077 (near HLA-DPA1) and rs9277378 and rs3128917 (both near HLA-DPB1) in 500 HBV carriers (hepatitis B surface antigen [HBsAg]-positive), 245 non-HBV infected controls (HBsAg- and antibody to hepatitis B core protein [anti-HBc]-negative), and 259 subjects with natural HBV clearance (HBsAg-negative, anti-HBc-positive). Inactive HBV carriers state was defined by HBV DNA levels2,000 IU/mL and persistently normal alanine aminotransferase level for least 12 months. RESULTS: Compared to the non-HBV infected subjects, the HBV carriers had a significantly lower frequency of the rs3077 T allele (P = 0.0040), rs9277378 A allele (P = 0.0068) and a trend for lower frequency of rs3128917 T allele (P = 0.054). Comparison between the HBV clearance subjects and HBV carriers showed that these alleles were associated with an increased chance of HBV clearance (rs3077: OR = 1.41, P = 0.0083; rs9277378: OR = 1.61, P = 0.00011; rs3128917: OR = 1.54, P = 0.00017). Significant associations between HLA-DP genotypes and HBV clearance were also found under different genetic models. Haplotype TAT was associated with an increased chance of HBV clearance (OR = 1.64, P = 0.0013). No association was found between these SNPs and HBV disease activity. CONCLUSIONS: Specific alleles and haplotypes of HLA-DP SNPs rs3077, rs9277378 and rs3128917 were associated with chronicity of HBV disease in the Chinese. Further studies are required to determine whether these SNPs influence the disease endemicity in different ethnic populations.
DescriptionConference Theme: Transforming Science to Clinical Practice
Topic: 8.b Clinical: abstract no. 634
This journal suppl. entitled: APASL Liver Week 2013
Persistent Identifierhttp://hdl.handle.net/10722/185006
ISSN
2015 Impact Factor: 1.125
2015 SCImago Journal Rankings: 0.669

 

DC FieldValueLanguage
dc.contributor.authorWong, Den_US
dc.contributor.authorWatanabe, Ten_US
dc.contributor.authorTanaka, Yen_US
dc.contributor.authorSeto, WKen_US
dc.contributor.authorLee, CKen_US
dc.contributor.authorFung, Jen_US
dc.contributor.authorLin, CKen_US
dc.contributor.authorHuang, FYen_US
dc.contributor.authorLai, CLen_US
dc.contributor.authorYuen, MFen_US
dc.date.accessioned2013-07-15T10:23:48Z-
dc.date.available2013-07-15T10:23:48Z-
dc.date.issued2013en_US
dc.identifier.citationThe 2013 Asian Pacific Association for the Study of the Liver (Liver Week 2013), Singapore, 6-10 June 2013. In Hepatology International, 2013, v. 7 n. 1 suppl., p. S192, abstract no. 634en_US
dc.identifier.issn1936-0533-
dc.identifier.urihttp://hdl.handle.net/10722/185006-
dc.descriptionConference Theme: Transforming Science to Clinical Practice-
dc.descriptionTopic: 8.b Clinical: abstract no. 634-
dc.descriptionThis journal suppl. entitled: APASL Liver Week 2013-
dc.description.abstractBACKGROUND/AIMS: The association between HLA-DP single nucleotide polymorphisms (SNPs) and chronic hepatitis B virus (HBV) infection varies between different populations. We aimed to study the association between HLA-DP SNPs and HBV infection and disease activity in the Chinese population of Hong Kong. METHODS: We genotyped SNPs rs3077 (near HLA-DPA1) and rs9277378 and rs3128917 (both near HLA-DPB1) in 500 HBV carriers (hepatitis B surface antigen [HBsAg]-positive), 245 non-HBV infected controls (HBsAg- and antibody to hepatitis B core protein [anti-HBc]-negative), and 259 subjects with natural HBV clearance (HBsAg-negative, anti-HBc-positive). Inactive HBV carriers state was defined by HBV DNA levels2,000 IU/mL and persistently normal alanine aminotransferase level for least 12 months. RESULTS: Compared to the non-HBV infected subjects, the HBV carriers had a significantly lower frequency of the rs3077 T allele (P = 0.0040), rs9277378 A allele (P = 0.0068) and a trend for lower frequency of rs3128917 T allele (P = 0.054). Comparison between the HBV clearance subjects and HBV carriers showed that these alleles were associated with an increased chance of HBV clearance (rs3077: OR = 1.41, P = 0.0083; rs9277378: OR = 1.61, P = 0.00011; rs3128917: OR = 1.54, P = 0.00017). Significant associations between HLA-DP genotypes and HBV clearance were also found under different genetic models. Haplotype TAT was associated with an increased chance of HBV clearance (OR = 1.64, P = 0.0013). No association was found between these SNPs and HBV disease activity. CONCLUSIONS: Specific alleles and haplotypes of HLA-DP SNPs rs3077, rs9277378 and rs3128917 were associated with chronicity of HBV disease in the Chinese. Further studies are required to determine whether these SNPs influence the disease endemicity in different ethnic populations.-
dc.languageengen_US
dc.publisherSpringer New York LLC. The Journal's web site is located at http://www.springer.com/west/home/medicine?SGWID=4-10054-70-173733513-0-
dc.relation.ispartofHepatology Internationalen_US
dc.rightsThe original publication is available at www.springerlink.com-
dc.subjectMedical sciences-
dc.subjectEndocrinology-
dc.titleRole of HLA-DP polymorphisms on chronicity and disease activity of hepatitis B infection in the Chineseen_US
dc.typeConference_Paperen_US
dc.identifier.emailWong, D: danywong@hku.hken_US
dc.identifier.emailSeto, WK: wkseto2@hku.hken_US
dc.identifier.emailFung, J: jfung@hkucc.hku.hken_US
dc.identifier.emailHuang, FY: fungyu@hkucc.hku.hken_US
dc.identifier.emailLai, CL: hrmelcl@hku.hken_US
dc.identifier.emailYuen, MF: mfyuen@hku.hken_US
dc.identifier.authorityWong, D=rp00492en_US
dc.identifier.authoritySeto, WK=rp01659en_US
dc.identifier.authorityFung, J=rp00518en_US
dc.identifier.authorityLai, CL=rp00314en_US
dc.identifier.doi10.1007/s12072-013-9429-0-
dc.identifier.hkuros215589en_US
dc.identifier.volume7en_US
dc.identifier.issue1 suppl.en_US
dc.identifier.spageS192en_US
dc.identifier.epageS192en_US
dc.publisher.placeUnited States-

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