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Conference Paper: BDNF-mediated GABAergic transmission in the rat vestibular nucleus regulates the developmental recognition of spatial orientation

TitleBDNF-mediated GABAergic transmission in the rat vestibular nucleus regulates the developmental recognition of spatial orientation
Authors
KeywordsBDNF
Plasticity
Vestibular
Issue Date2012
PublisherSociety for Neuroscience.
Citation
The 2012 Annual Meeting of the Society for Neuroscience (SfN), New Orleans, LA., 13-17 October 2012. In Abstracts of the Neuroscience, 2012, no. 735.11/A55 How to Cite?
AbstractBrain-derived neurotrophic factor (BDNF) has been widely implicated in the maturation of GABAergic transmission. We have demonstrated that neonatal rats implanted with BDNF-loaded Elvax slices over the dorsal surface of brainstem vestibular nuclei showed an accelerated re-orientation of body against gravity. We hypothesized that this acceleration caused by BDNF is due to changes in the maturation of GABAergic transmission. To investigate this, long-term changes of inhibitory synaptic transmission were studied using whole-cell patch-clamp experiments in medial vestibular (MV) neurons of rats. We found that these neurons exhibited a developmental change in plasticity from GABAA receptor-mediated inhibitory long-term depression (iLTD) in early developmental stage to inhibitory long-term potentiation (iLTP) in late postnatal stage. In neonatal preparations, BDNF treatment could induce a slight reduction in GABA-mediated current but iLTD was still expressed. In late postnatal preparations, iLTP could no longer be triggered when the brainstem slices were incubated with BDNF. Instead, iLTD, which is indicative of early developmental stages, could be re-induced with BDNF treatment. These results indicate that BDNF modulates the efficacy of GABA synapses through development. Taken together, our data suggest that developmental acquisition of spatial orientation can be modified by BDNF-mediated refinement of neural networks in the vestibular nucleus.
DescriptionPoster Session 735 - Auditory System: no. 735.11/A55
Persistent Identifierhttp://hdl.handle.net/10722/184911

 

DC FieldValueLanguage
dc.contributor.authorBotelho, FPen_US
dc.contributor.authorLai, CHen_US
dc.contributor.authorShum, DKYen_US
dc.contributor.authorChan, YSen_US
dc.date.accessioned2013-07-15T10:18:20Z-
dc.date.available2013-07-15T10:18:20Z-
dc.date.issued2012en_US
dc.identifier.citationThe 2012 Annual Meeting of the Society for Neuroscience (SfN), New Orleans, LA., 13-17 October 2012. In Abstracts of the Neuroscience, 2012, no. 735.11/A55en_US
dc.identifier.urihttp://hdl.handle.net/10722/184911-
dc.descriptionPoster Session 735 - Auditory System: no. 735.11/A55-
dc.description.abstractBrain-derived neurotrophic factor (BDNF) has been widely implicated in the maturation of GABAergic transmission. We have demonstrated that neonatal rats implanted with BDNF-loaded Elvax slices over the dorsal surface of brainstem vestibular nuclei showed an accelerated re-orientation of body against gravity. We hypothesized that this acceleration caused by BDNF is due to changes in the maturation of GABAergic transmission. To investigate this, long-term changes of inhibitory synaptic transmission were studied using whole-cell patch-clamp experiments in medial vestibular (MV) neurons of rats. We found that these neurons exhibited a developmental change in plasticity from GABAA receptor-mediated inhibitory long-term depression (iLTD) in early developmental stage to inhibitory long-term potentiation (iLTP) in late postnatal stage. In neonatal preparations, BDNF treatment could induce a slight reduction in GABA-mediated current but iLTD was still expressed. In late postnatal preparations, iLTP could no longer be triggered when the brainstem slices were incubated with BDNF. Instead, iLTD, which is indicative of early developmental stages, could be re-induced with BDNF treatment. These results indicate that BDNF modulates the efficacy of GABA synapses through development. Taken together, our data suggest that developmental acquisition of spatial orientation can be modified by BDNF-mediated refinement of neural networks in the vestibular nucleus.-
dc.languageengen_US
dc.publisherSociety for Neuroscience.-
dc.relation.ispartofAbstracts of the Neuroscience 2012en_US
dc.rightsAbstracts of the Neuroscience 2012. Copyright © Society for Neuroscience.-
dc.subjectBDNF-
dc.subjectPlasticity-
dc.subjectVestibular-
dc.titleBDNF-mediated GABAergic transmission in the rat vestibular nucleus regulates the developmental recognition of spatial orientationen_US
dc.typeConference_Paperen_US
dc.identifier.emailBotelho, FP: fbotelho@hku.hken_US
dc.identifier.emailLai, CH: chlaib@hku.hken_US
dc.identifier.emailShum, DKY: shumdkhk@hkucc.hku.hken_US
dc.identifier.emailChan, YS: yschan@hku.hk-
dc.identifier.authorityLai, CH=rp00396en_US
dc.identifier.authorityShum, DKY=rp00321en_US
dc.identifier.authorityChan, YS=rp00318en_US
dc.description.naturelink_to_OA_fulltext-
dc.identifier.hkuros216125en_US
dc.publisher.placeUnited States-

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