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Conference Paper: Endocannabinoid regulates developmental plasticity of GABAergic synapses in the rat medial vestibular nucleus

TitleEndocannabinoid regulates developmental plasticity of GABAergic synapses in the rat medial vestibular nucleus
Authors
KeywordsBiology
Biochemistry medical sciences
Psychiatry and neurology
Issue Date2012
PublisherBlackwell Publishing Ltd.
Citation
The 11th Biennial Meeting of the Asian Pacific Society for Neurochemistry and the 55th Annual Meeting of the Japanese Society for Neurochemistry in conjunction of 34th Annual Meeting of Japanese Society of Biological Psychiatry (JSN-APSN 2012), Kobe, Japan, 30 September-2 October 2012. In Journal of Neurochemistry, 2012, v. 123 suppl. s1, p. 80, abstract P04-10 How to Cite?
AbstractLong-term depression of inhibitory responses (iLTD), mediated via retrograde signaling of endocannabinoid (eCB), have been reported in the amygdala, hippocampus and visual cortex. The role of eCB on presynaptic plasticity in the vestibular nucleus which plays a key role in spatial recognition remains unexplored. Immunoreactivity of eCB receptor was observed in the vestibular nucleus of postnatal rats. Whole-cell patch-clamp experiments were also performed on brainstem slice preparations of these animals. Theta-burst stimulation delivered to vestibular afferents could induce iLTD of GABAA receptor-mediated evoked-IPSCs in medial vestibular neurons. In P5-7 rats, iLTD was induced in 80% of the neurons tested. Application of AM251 (antagonist of type 1 cannabinoid receptor) decreased the percentage to 30%. In P8-10 rats, however, the percentage of neurons in which iLTD could be induced was found to be 30%. Treatment with WIN55 (agonist of type 1 cannabinoid receptor) increased the percentage to 70%. Our results therefore indicate that eCB plays an age-dependent role in modulating the efficacy of GABAergic synapses in the vestibular nucleus, thereby regulating activities of neural network within the central vestibular system.
DescriptionThis journal suppl. is the Special Issue of the JSN-APSN 2012
Poster Session I
Persistent Identifierhttp://hdl.handle.net/10722/184909
ISSN
2015 Impact Factor: 3.842
2015 SCImago Journal Rankings: 2.021
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorShi, Wen_US
dc.contributor.authorBotelho, FPen_US
dc.contributor.authorShum, DKYen_US
dc.contributor.authorChan, YSen_US
dc.date.accessioned2013-07-15T10:18:20Z-
dc.date.available2013-07-15T10:18:20Z-
dc.date.issued2012en_US
dc.identifier.citationThe 11th Biennial Meeting of the Asian Pacific Society for Neurochemistry and the 55th Annual Meeting of the Japanese Society for Neurochemistry in conjunction of 34th Annual Meeting of Japanese Society of Biological Psychiatry (JSN-APSN 2012), Kobe, Japan, 30 September-2 October 2012. In Journal of Neurochemistry, 2012, v. 123 suppl. s1, p. 80, abstract P04-10en_US
dc.identifier.issn0022-3042en_US
dc.identifier.urihttp://hdl.handle.net/10722/184909-
dc.descriptionThis journal suppl. is the Special Issue of the JSN-APSN 2012-
dc.descriptionPoster Session I-
dc.description.abstractLong-term depression of inhibitory responses (iLTD), mediated via retrograde signaling of endocannabinoid (eCB), have been reported in the amygdala, hippocampus and visual cortex. The role of eCB on presynaptic plasticity in the vestibular nucleus which plays a key role in spatial recognition remains unexplored. Immunoreactivity of eCB receptor was observed in the vestibular nucleus of postnatal rats. Whole-cell patch-clamp experiments were also performed on brainstem slice preparations of these animals. Theta-burst stimulation delivered to vestibular afferents could induce iLTD of GABAA receptor-mediated evoked-IPSCs in medial vestibular neurons. In P5-7 rats, iLTD was induced in 80% of the neurons tested. Application of AM251 (antagonist of type 1 cannabinoid receptor) decreased the percentage to 30%. In P8-10 rats, however, the percentage of neurons in which iLTD could be induced was found to be 30%. Treatment with WIN55 (agonist of type 1 cannabinoid receptor) increased the percentage to 70%. Our results therefore indicate that eCB plays an age-dependent role in modulating the efficacy of GABAergic synapses in the vestibular nucleus, thereby regulating activities of neural network within the central vestibular system.-
dc.languageengen_US
dc.publisherBlackwell Publishing Ltd.en_US
dc.relation.ispartofJournal of Neurochemistryen_US
dc.rightsThe definitive version is available at www.blackwell-synergy.comen_US
dc.subjectBiology-
dc.subjectBiochemistry medical sciences-
dc.subjectPsychiatry and neurology-
dc.titleEndocannabinoid regulates developmental plasticity of GABAergic synapses in the rat medial vestibular nucleusen_US
dc.typeConference_Paperen_US
dc.identifier.emailShi, W: u3001444@hku.hken_US
dc.identifier.emailBotelho, FP: fbotelho@hku.hken_US
dc.identifier.emailShum, DKY: shumdkhk@hkucc.hku.hk-
dc.identifier.emailChan, YS: yschan@hku.hk-
dc.identifier.authorityShum, DKY=rp00321en_US
dc.identifier.authorityChan, YS=rp00318en_US
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1111/j.1471-4159.2012.07905.x-
dc.identifier.hkuros216071en_US
dc.identifier.volume123en_US
dc.identifier.issuesuppl. s1en_US
dc.identifier.spage80en_US
dc.identifier.epage80en_US
dc.identifier.isiWOS:000208866100004-
dc.publisher.placeUnited Kingdom-
dc.customcontrol.immutablesml 130723-

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