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Article: Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia

TitleGenome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia
Authors
Issue Date2012
PublisherNature Publishing Group. The Journal's web site is located at http://www.genetics.nature.com
Citation
Nature Genetics, 2012, v. 44 n. 12, p. 1330-1335 How to Cite?
AbstractTo identify common genetic variants that contribute to lung cancer susceptibility, we conducted a multistage genome-wide association study of lung cancer in Asian women who never smoked. We scanned 5,510 never-smoking female lung cancer cases and 4,544 controls drawn from 14 studies from mainland China, South Korea, Japan, Singapore, Taiwan and Hong Kong. We genotyped the most promising variants (associated at P < 5 × 10-6) in an additional 1,099 cases and 2,913 controls. We identified three new susceptibility loci at 10q25.2 (rs7086803, P = 3.54 × 10-18), 6q22.2 (rs9387478, P = 4.14 × 10-10) and 6p21.32 (rs2395185, P = 9.51 × 10-9). We also confirmed associations reported for loci at 5p15.33 and 3q28 and a recently reported finding at 17q24.3. We observed no evidence of association for lung cancer at 15q25 in never-smoking women in Asia, providing strong evidence that this locus is not associated with lung cancer independent of smoking. © 2012 Nature America, Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/184313
ISSN
2015 Impact Factor: 31.616
2015 SCImago Journal Rankings: 23.762
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLan, Qen_US
dc.contributor.authorHsiung, CAen_US
dc.contributor.authorMatsuo, Ken_US
dc.contributor.authorHong, YCen_US
dc.contributor.authorSeow, Aen_US
dc.contributor.authorWang, Zen_US
dc.contributor.authorHosgood, HDen_US
dc.contributor.authorChen, Ken_US
dc.contributor.authorWang, JCen_US
dc.contributor.authorChatterjee, Nen_US
dc.contributor.authorHu, Wen_US
dc.contributor.authorLi, Yen_US
dc.contributor.authorChoi, JEen_US
dc.contributor.authorSu, WCen_US
dc.contributor.authorPark, KHen_US
dc.contributor.authorSung, SWen_US
dc.contributor.authorKang, CHen_US
dc.contributor.authorShu, XOen_US
dc.contributor.authorHu, Len_US
dc.contributor.authorChen, CHen_US
dc.contributor.authorPao, Wen_US
dc.contributor.authorDong, Jen_US
dc.contributor.authorKim, YCen_US
dc.contributor.authorYang, TYen_US
dc.contributor.authorXu, Jen_US
dc.contributor.authorGuan, Pen_US
dc.contributor.authorChen, CYen_US
dc.contributor.authorTan, Wen_US
dc.contributor.authorSu, Jen_US
dc.contributor.authorWang, CLen_US
dc.contributor.authorLi, Hen_US
dc.contributor.authorSihoe, ADLen_US
dc.contributor.authorKim, Cen_US
dc.contributor.authorZhao, Zen_US
dc.contributor.authorChen, Yen_US
dc.contributor.authorChoi, YYen_US
dc.contributor.authorHung, JYen_US
dc.contributor.authorKim, JSen_US
dc.contributor.authorVermeulen, Ren_US
dc.contributor.authorYoon, HIen_US
dc.contributor.authorCai, Qen_US
dc.contributor.authorLin, CCen_US
dc.contributor.authorPark, IKen_US
dc.contributor.authorHe, Qen_US
dc.contributor.authorXu, Pen_US
dc.contributor.authorPerng, RPen_US
dc.contributor.authorKohno, Ten_US
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dc.contributor.authorKweon, SSen_US
dc.contributor.authorLim, WYen_US
dc.contributor.authorChen, KCen_US
dc.contributor.authorChow, WHen_US
dc.contributor.authorZhou, Ben_US
dc.contributor.authorJi, BTen_US
dc.contributor.authorChan, JKCen_US
dc.contributor.authorChu, Men_US
dc.contributor.authorLi, YJen_US
dc.contributor.authorWong, MPen_US
dc.contributor.authorYokota, Jen_US
dc.contributor.authorLi, Jen_US
dc.contributor.authorChen, Hen_US
dc.contributor.authorXiang, YBen_US
dc.contributor.authorYu, CJen_US
dc.contributor.authorShin, MHen_US
dc.contributor.authorKunitoh, Hen_US
dc.contributor.authorWu, Gen_US
dc.contributor.authorJin, Len_US
dc.contributor.authorLo, YLen_US
dc.contributor.authorShiraishi, Ken_US
dc.contributor.authorZheng, Wen_US
dc.contributor.authorChen, YHen_US
dc.contributor.authorLin, HCen_US
dc.contributor.authorWu, Ten_US
dc.contributor.authorWu, YLen_US
dc.contributor.authorFraumeni, JFen_US
dc.contributor.authorYang, PCen_US
dc.contributor.authorLin, Den_US
dc.contributor.authorChanock, SJen_US
dc.contributor.authorCaporaso, Nen_US
dc.contributor.authorRothman, Nen_US
dc.contributor.authorPark, JYen_US
dc.contributor.authorChen, CJen_US
dc.contributor.authorKim, YHen_US
dc.contributor.authorLiu, Jen_US
dc.contributor.authorKim, YTen_US
dc.contributor.authorLandi, MTen_US
dc.contributor.authorShen, Hen_US
dc.contributor.authorLawrence, Cen_US
dc.contributor.authorBurdett, Len_US
dc.contributor.authorYeager, Men_US
dc.contributor.authorYuenger, Jen_US
dc.contributor.authorJacobs, KBen_US
dc.contributor.authorChang, ISen_US
dc.contributor.authorMitsudomi, Ten_US
dc.contributor.authorJeon, HSen_US
dc.contributor.authorKim, HNen_US
dc.contributor.authorChang, GCen_US
dc.contributor.authorBassig, BAen_US
dc.contributor.authorTucker, Men_US
dc.contributor.authorWei, Fen_US
dc.contributor.authorYin, Zen_US
dc.contributor.authorWu, Cen_US
dc.contributor.authorAn, SJen_US
dc.contributor.authorQian, Ben_US
dc.contributor.authorLee, VHFen_US
dc.contributor.authorHsiao, CFen_US
dc.contributor.authorLu, Den_US
dc.contributor.authorSung, JSen_US
dc.contributor.authorKim, JHen_US
dc.contributor.authorGao, YTen_US
dc.contributor.authorTsai, YHen_US
dc.contributor.authorJung, YJen_US
dc.contributor.authorGuo, Hen_US
dc.contributor.authorHu, Zen_US
dc.contributor.authorChen, YMen_US
dc.contributor.authorHutchinson, Aen_US
dc.contributor.authorWang, WCen_US
dc.contributor.authorKlein, Ren_US
dc.contributor.authorChung, CCen_US
dc.contributor.authorOh, IJen_US
dc.contributor.authorChen, KYen_US
dc.contributor.authorBerndt, SIen_US
dc.contributor.authorHe, Xen_US
dc.contributor.authorWu, Wen_US
dc.contributor.authorChang, Jen_US
dc.contributor.authorLiu, Len_US
dc.contributor.authorZhang, XCen_US
dc.contributor.authorHuang, MSen_US
dc.contributor.authorZheng, Hen_US
dc.contributor.authorWang, Jen_US
dc.contributor.authorZhao, Xen_US
dc.date.accessioned2013-07-10T06:23:38Z-
dc.date.available2013-07-10T06:23:38Z-
dc.date.issued2012en_US
dc.identifier.citationNature Genetics, 2012, v. 44 n. 12, p. 1330-1335en_US
dc.identifier.issn1061-4036en_US
dc.identifier.urihttp://hdl.handle.net/10722/184313-
dc.description.abstractTo identify common genetic variants that contribute to lung cancer susceptibility, we conducted a multistage genome-wide association study of lung cancer in Asian women who never smoked. We scanned 5,510 never-smoking female lung cancer cases and 4,544 controls drawn from 14 studies from mainland China, South Korea, Japan, Singapore, Taiwan and Hong Kong. We genotyped the most promising variants (associated at P < 5 × 10-6) in an additional 1,099 cases and 2,913 controls. We identified three new susceptibility loci at 10q25.2 (rs7086803, P = 3.54 × 10-18), 6q22.2 (rs9387478, P = 4.14 × 10-10) and 6p21.32 (rs2395185, P = 9.51 × 10-9). We also confirmed associations reported for loci at 5p15.33 and 3q28 and a recently reported finding at 17q24.3. We observed no evidence of association for lung cancer at 15q25 in never-smoking women in Asia, providing strong evidence that this locus is not associated with lung cancer independent of smoking. © 2012 Nature America, Inc. All rights reserved.en_US
dc.languageengen_US
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.genetics.nature.comen_US
dc.relation.ispartofNature Geneticsen_US
dc.subject.meshAdenocarcinoma - Geneticsen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAsian Continental Ancestry Group - Geneticsen_US
dc.subject.meshCarcinoma, Squamous Cell - Geneticsen_US
dc.subject.meshChromosomes, Human, Pair 10 - Geneticsen_US
dc.subject.meshChromosomes, Human, Pair 15 - Geneticsen_US
dc.subject.meshChromosomes, Human, Pair 17en_US
dc.subject.meshChromosomes, Human, Pair 5 - Geneticsen_US
dc.subject.meshChromosomes, Human, Pair 6 - Geneticsen_US
dc.subject.meshFemaleen_US
dc.subject.meshGenetic Locien_US
dc.subject.meshGenetic Predisposition To Diseaseen_US
dc.subject.meshGenome-Wide Association Studyen_US
dc.subject.meshHumansen_US
dc.subject.meshLung Neoplasms - Geneticsen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPolymorphism, Single Nucleotideen_US
dc.subject.meshSmokingen_US
dc.titleGenome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asiaen_US
dc.typeArticleen_US
dc.identifier.emailWong, MP: mwpik@hku.hken_US
dc.identifier.emailAn, SJ: mwpik@hku.hken_US
dc.identifier.emailZhao, Z: junwen@hkucc.hku.hken_US
dc.identifier.authorityWong, MP=rp00348en_US
dc.identifier.authorityAn, SJ=rp00348en_US
dc.identifier.authorityZhao, Z=rp00280en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1038/ng.2456en_US
dc.identifier.pmid23143601-
dc.identifier.scopuseid_2-s2.0-84870502715en_US
dc.identifier.hkuros218887-
dc.identifier.hkuros247053-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84870502715&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume44en_US
dc.identifier.issue12en_US
dc.identifier.spage1330en_US
dc.identifier.epage1335en_US
dc.identifier.isiWOS:000311713200011-
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