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Article: Relationship between autoantibody clustering and clinical subsets in SLE: cluster and association analyses in Hong Kong Chinese

TitleRelationship between autoantibody clustering and clinical subsets in SLE: cluster and association analyses in Hong Kong Chinese
Authors
Issue Date2013
PublisherOxford University Press. The Journal's web site is located at http://rheumatology.oxfordjournals.org/
Citation
Rheumatology, 2013, v. 52 n. 2, p. 337-345 How to Cite?
AbstractOBJECTIVE: This study aims to identify the existence of, and relationship between autoantibody clusters and clinical subsets in Chinese SLE patients. METHODS: Data from 1928 SLE patients from Hong Kong were analysed. Using cluster analysis, patients were grouped by autoantibodies into clusters. The frequencies of various clinical manifestations were then compared between each cluster. Separate association analyses between individual autoantibodies and clinical manifestations as well as between clinical manifestations were also performed without any prior clustering. RESULTS: Three separate autoantibody clusters were identified, each with significantly different clinical manifestations. Cluster 1 was characterized by anti-dsDNA and the greatest prevalence of renal disorder but the lowest frequencies of other clinical manifestations. Cluster 2 was represented by the predominance of anti-Smith, anti-RNP and aPL, with greater prevalence of malar rash, oral ulcers, arthritis and serositis. Cluster 3 was characterized by anti-Ro and anti-La with greater prevalence of discoid rash, photosensitivity and haematological involvement. Individual association analysis also revealed similar findings. Patients of clusters 2 and 3 were more closely related, while cluster 1 was more distinct, associated with renal disorder only and negatively associated or not associated with other manifestations. CONCLUSION: We conclude that autoantibody clustering and clinical subsets exist in SLE patients of our locality. These clusters may be viewed as a bipolar spectrum of related autoantibody and clinical manifestations. At one end are patients with over-representation of anti-dsDNA and renal disorder, while at the other end are two distinct autoantibody clusters (anti-Sm/anti-RNP/aPL and anti-Ro/anti-La) with overlapping of other clinical manifestations.
Persistent Identifierhttp://hdl.handle.net/10722/183751
ISSN
2015 Impact Factor: 4.524
2015 SCImago Journal Rankings: 1.449
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLi, PHen_US
dc.contributor.authorWong, WHSen_US
dc.contributor.authorLee, TLen_US
dc.contributor.authorLau, WCSen_US
dc.contributor.authorChan, DTMen_US
dc.contributor.authorLeung, AMHen_US
dc.contributor.authorTong, KLen_US
dc.contributor.authorTse, NKCen_US
dc.contributor.authorMok, CCen_US
dc.contributor.authorWong, SNen_US
dc.contributor.authorLee, KWen_US
dc.contributor.authorHo, MHKen_US
dc.contributor.authorLee, PPWen_US
dc.contributor.authorChong, CYen_US
dc.contributor.authorWong, RWSen_US
dc.contributor.authorMok, TMYen_US
dc.contributor.authorYing, SKYen_US
dc.contributor.authorFung, SKSen_US
dc.contributor.authorLai, WMen_US
dc.contributor.authorYang, Wen_US
dc.contributor.authorLau, YLen_US
dc.date.accessioned2013-06-18T04:12:44Z-
dc.date.available2013-06-18T04:12:44Z-
dc.date.issued2013en_US
dc.identifier.citationRheumatology, 2013, v. 52 n. 2, p. 337-345en_US
dc.identifier.issn1462-0324-
dc.identifier.urihttp://hdl.handle.net/10722/183751-
dc.description.abstractOBJECTIVE: This study aims to identify the existence of, and relationship between autoantibody clusters and clinical subsets in Chinese SLE patients. METHODS: Data from 1928 SLE patients from Hong Kong were analysed. Using cluster analysis, patients were grouped by autoantibodies into clusters. The frequencies of various clinical manifestations were then compared between each cluster. Separate association analyses between individual autoantibodies and clinical manifestations as well as between clinical manifestations were also performed without any prior clustering. RESULTS: Three separate autoantibody clusters were identified, each with significantly different clinical manifestations. Cluster 1 was characterized by anti-dsDNA and the greatest prevalence of renal disorder but the lowest frequencies of other clinical manifestations. Cluster 2 was represented by the predominance of anti-Smith, anti-RNP and aPL, with greater prevalence of malar rash, oral ulcers, arthritis and serositis. Cluster 3 was characterized by anti-Ro and anti-La with greater prevalence of discoid rash, photosensitivity and haematological involvement. Individual association analysis also revealed similar findings. Patients of clusters 2 and 3 were more closely related, while cluster 1 was more distinct, associated with renal disorder only and negatively associated or not associated with other manifestations. CONCLUSION: We conclude that autoantibody clustering and clinical subsets exist in SLE patients of our locality. These clusters may be viewed as a bipolar spectrum of related autoantibody and clinical manifestations. At one end are patients with over-representation of anti-dsDNA and renal disorder, while at the other end are two distinct autoantibody clusters (anti-Sm/anti-RNP/aPL and anti-Ro/anti-La) with overlapping of other clinical manifestations.-
dc.languageengen_US
dc.publisherOxford University Press. The Journal's web site is located at http://rheumatology.oxfordjournals.org/en_US
dc.relation.ispartofRheumatologyen_US
dc.rightsThis is a pre-copy-editing, author-produced PDF of an article accepted for publication in Rheumatology following peer review. The definitive publisher-authenticated version Rheumatology, 2013, v. 52 n. 2, p. 337-345 is available online at: http://rheumatology.oxfordjournals.org/content/52/2/337-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshAntibodies, Antinuclear - blood-
dc.subject.meshAutoantibodies - blood-
dc.subject.meshCluster Analysis-
dc.subject.meshHong Kong - epidemiology-
dc.subject.meshLupus Erythematosus, Systemic - ethnology - immunology-
dc.titleRelationship between autoantibody clustering and clinical subsets in SLE: cluster and association analyses in Hong Kong Chineseen_US
dc.typeArticleen_US
dc.identifier.emailLi, PH: phileh.li@gmail.comen_US
dc.identifier.emailWong, WHS: whswong@hku.hken_US
dc.identifier.emailLee, TL: leetsz@hkucc.hku.hken_US
dc.identifier.emailLau, WCS: cslau@hku.hken_US
dc.identifier.emailChan, DTM: dtmchan@hku.hken_US
dc.identifier.emailWong, SN: snwong@hkucc.hku.hken_US
dc.identifier.emailHo, MHK: marcoho@hku.hken_US
dc.identifier.emailLee, PPW: ppwlee@hku.hken_US
dc.identifier.emailWong, RWS: rwswong@hkucc.hku.hken_US
dc.identifier.emailMok, TMY: temy@hkucc.hku.hken_US
dc.identifier.emailYang, W: yangwl@hkucc.hku.hken_US
dc.identifier.emailLau, YL: lauylung@hku.hk-
dc.identifier.authorityLau, WCS=rp01348en_US
dc.identifier.authorityChan, DTM=rp00394en_US
dc.identifier.authorityLee, PPW=rp00462en_US
dc.identifier.authorityMok, TMY=rp00490en_US
dc.identifier.authorityYang, W=rp00524en_US
dc.identifier.authorityLau, YL=rp00361en_US
dc.description.naturepostprint-
dc.identifier.doi10.1093/rheumatology/kes261-
dc.identifier.pmid23038697-
dc.identifier.scopuseid_2-s2.0-84873880788-
dc.identifier.hkuros214551en_US
dc.identifier.hkuros214866-
dc.identifier.volume52en_US
dc.identifier.issue2en_US
dc.identifier.spage337en_US
dc.identifier.epage345en_US
dc.identifier.isiWOS:000314054800018-
dc.publisher.placeUnited Kingdom-

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