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Conference Paper: Variants, clinical characteristics and prognostic factors of Guillain Barre Syndrome in Chinese

TitleVariants, clinical characteristics and prognostic factors of Guillain Barre Syndrome in Chinese
Authors
KeywordsMedical sciences
Psychiatry and neurology
Issue Date2013
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.neurology.org
Citation
The 65th Annual Meeting of the American Academy of Neurology (AAN 2013), San Diego, CA., 16-23 March 2013. In Neurology, 2013, v. 80 n. 1 meeting abstracts, abstract P01.135 How to Cite?
AbstractOBJECTIVE: To investigate the variants, clinical characteristics and prognostic factors of Guillain Barre Syndrome (GBS) in Hong Kong Chinese. BACKGROUND: The variants, clinical characteristics and prognostic factors of adults with GBS in Hong Kong has not been widely studied previously. DESIGN/METHODS: We performed a retrospective review of adults with GBS admitted to Queen Mary Hospital, Hong Kong during the period 1997-2011. RESULTS: Mean age of the patients was 57+/-17 years and the mean hospital stay was 36+/-69 days. Male:female ratio was 1.5:1. Of the 63 patients with GBS, 4.8% had acute motor axonal neuropathy, 17.5% with Miller-Fisher syndrome and 77.8% were of the acute inflammatory demyelinating polyneuropathy together with other unspecified subtypes. 49.2% had preceding upper respiratory tract illness, 4.76% preceding gastrointestinal illness, whilst 7.94% received vaccination during the 6weeks preceding onset of neurological symptoms. 22.2% patients were admitted to Intensive Care Unit and 12.7% patients required mechanical ventilation. 19.0% patients were treated conservatively, 39.7% received intravenous immunoglobulin only, 30.2% received plasmapharesis only and 11.0% received both intravenous immunoglobulin and plasmapharesis. 36.1% of patients was associated with poor functional recovery (requiring walking with aid at 6months after admission). Multivariate analysis revealed that necessity of mechanical ventilation during hospitalization (Odds Ratio = 43.3, 95% confidence interval: 1.2-1539.4, p=0.039) was an independent predictor of poor functional recovery at 6months after admission. Receiver Operating Characteristics curve also showed that an Erasmus GBS Outcome Score>4 was associated with good functional recovery with area under Receiver Operating Characteristic Curve being 0.87 (p<0.0001). CONCLUSIONS: Miller Fisher syndrome is more common in the Chinese population compared to the West. Necessity of mechanical ventilation during hospitalization is an independent predictor of poor functional recovery and the Erasmus GBS Outcome Score is a useful score in predicting functional recovery.
DescriptionSession P01 - Peripheral Nerve: Acute Inflammatory and Nutritional: abstract P01.135
Abstracts from the AAN Annual Meeting in San Diego were published online only this year, and can be viewed at: www.abstracts2view.com/aan or http://www.neurology.org/content/vol80/1_MeetingAbstracts
Persistent Identifierhttp://hdl.handle.net/10722/182110
ISSN
2015 Impact Factor: 8.166
2015 SCImago Journal Rankings: 3.691

 

DC FieldValueLanguage
dc.contributor.authorKwok, KHMen_US
dc.contributor.authorTsui, KHLen_US
dc.contributor.authorWong, DWYen_US
dc.contributor.authorWong, YKen_US
dc.contributor.authorChang, RSKen_US
dc.contributor.authorHon, SFKen_US
dc.contributor.authorMak, Wen_US
dc.contributor.authorCheung, Ren_US
dc.contributor.authorHo, SLen_US
dc.contributor.authorChan, KHen_US
dc.contributor.authorLau, Gen_US
dc.date.accessioned2013-04-17T07:21:59Z-
dc.date.available2013-04-17T07:21:59Z-
dc.date.issued2013en_US
dc.identifier.citationThe 65th Annual Meeting of the American Academy of Neurology (AAN 2013), San Diego, CA., 16-23 March 2013. In Neurology, 2013, v. 80 n. 1 meeting abstracts, abstract P01.135en_US
dc.identifier.issn0028-3878-
dc.identifier.urihttp://hdl.handle.net/10722/182110-
dc.descriptionSession P01 - Peripheral Nerve: Acute Inflammatory and Nutritional: abstract P01.135-
dc.descriptionAbstracts from the AAN Annual Meeting in San Diego were published online only this year, and can be viewed at: www.abstracts2view.com/aan or http://www.neurology.org/content/vol80/1_MeetingAbstracts-
dc.description.abstractOBJECTIVE: To investigate the variants, clinical characteristics and prognostic factors of Guillain Barre Syndrome (GBS) in Hong Kong Chinese. BACKGROUND: The variants, clinical characteristics and prognostic factors of adults with GBS in Hong Kong has not been widely studied previously. DESIGN/METHODS: We performed a retrospective review of adults with GBS admitted to Queen Mary Hospital, Hong Kong during the period 1997-2011. RESULTS: Mean age of the patients was 57+/-17 years and the mean hospital stay was 36+/-69 days. Male:female ratio was 1.5:1. Of the 63 patients with GBS, 4.8% had acute motor axonal neuropathy, 17.5% with Miller-Fisher syndrome and 77.8% were of the acute inflammatory demyelinating polyneuropathy together with other unspecified subtypes. 49.2% had preceding upper respiratory tract illness, 4.76% preceding gastrointestinal illness, whilst 7.94% received vaccination during the 6weeks preceding onset of neurological symptoms. 22.2% patients were admitted to Intensive Care Unit and 12.7% patients required mechanical ventilation. 19.0% patients were treated conservatively, 39.7% received intravenous immunoglobulin only, 30.2% received plasmapharesis only and 11.0% received both intravenous immunoglobulin and plasmapharesis. 36.1% of patients was associated with poor functional recovery (requiring walking with aid at 6months after admission). Multivariate analysis revealed that necessity of mechanical ventilation during hospitalization (Odds Ratio = 43.3, 95% confidence interval: 1.2-1539.4, p=0.039) was an independent predictor of poor functional recovery at 6months after admission. Receiver Operating Characteristics curve also showed that an Erasmus GBS Outcome Score>4 was associated with good functional recovery with area under Receiver Operating Characteristic Curve being 0.87 (p<0.0001). CONCLUSIONS: Miller Fisher syndrome is more common in the Chinese population compared to the West. Necessity of mechanical ventilation during hospitalization is an independent predictor of poor functional recovery and the Erasmus GBS Outcome Score is a useful score in predicting functional recovery.-
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.neurology.org-
dc.relation.ispartofNeurologyen_US
dc.subjectMedical sciences-
dc.subjectPsychiatry and neurology-
dc.titleVariants, clinical characteristics and prognostic factors of Guillain Barre Syndrome in Chineseen_US
dc.typeConference_Paperen_US
dc.identifier.emailWong, YK: debbieyk@hku.hken_US
dc.identifier.emailChang, RSK: richardcsk@gmail.comen_US
dc.identifier.emailMak, W: makwaiwo@hotmail.comen_US
dc.identifier.emailCheung, R: rtcheung@hku.hken_US
dc.identifier.emailHo, SL: slho@hku.hken_US
dc.identifier.emailChan, KH: koonho@hku.hken_US
dc.identifier.emailLau, G: gkklau@hku.hk-
dc.identifier.authorityCheung, R=rp00434en_US
dc.identifier.authorityHo, SL=rp00240en_US
dc.identifier.authorityChan, KH=rp00537en_US
dc.identifier.authorityLau, G=rp01499en_US
dc.description.naturelink_to_OA_fulltext-
dc.identifier.hkuros213853en_US
dc.identifier.volume80-
dc.identifier.issue1 meeting abstracts-
dc.publisher.placeUnited States-

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