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Article: Meta-analysis Followed by Replication Identifies Loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as Associated with Systemic Lupus Erythematosus in Asians

TitleMeta-analysis Followed by Replication Identifies Loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as Associated with Systemic Lupus Erythematosus in Asians
Authors
Issue Date2013
Citation
The American Journal of Human Genetics, 2013, v. 92, p. 41-51 How to Cite?
AbstractSystemic lupus erythematosus (SLE) is a prototype autoimmune disease with a strong genetic involvement and ethnic differences. Susceptibility genes identified so far only explain a small portion of the genetic heritability of SLE, suggesting that many more loci are yet to be uncovered for this disease. In this study, we performed a meta-analysis of genome-wide association studies on SLE in Chinese Han populations and followed up the findings by replication in four additional Asian cohorts with a total of 5,365 cases and 10,054 corresponding controls. We identified genetic variants in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with the disease. These findings point to potential roles of cell-cycle regulation, autophagy, and DNA demethylation in SLE pathogenesis. For the region involving TET3 and that involving CDKN1B, multiple independent SNPs were identified, highlighting a phenomenon that might partially explain the missing heritability of complex diseases. © 2013 The American Society of Human Genetics.
Persistent Identifierhttp://hdl.handle.net/10722/181677
ISSN
2015 Impact Factor: 10.794
2015 SCImago Journal Rankings: 8.769
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorYang, Wen_US
dc.contributor.authorTang, Hen_US
dc.contributor.authorZhang, Yen_US
dc.contributor.authorTang, Xen_US
dc.contributor.authorZheng, Jen_US
dc.contributor.authorSun, Len_US
dc.contributor.authorYang, Jen_US
dc.contributor.authorCui, Yen_US
dc.contributor.authorZhang, Len_US
dc.contributor.authorHirankarn, Nen_US
dc.contributor.authorCheng, Hen_US
dc.contributor.authorPan, HFen_US
dc.contributor.authorGao, Jen_US
dc.contributor.authorLee, TLen_US
dc.contributor.authorSheng, Yen_US
dc.contributor.authorLau, WCSen_US
dc.contributor.authorLi, Yen_US
dc.contributor.authorChan, TMen_US
dc.contributor.authorYin, Xen_US
dc.contributor.authorYing, Den_US
dc.contributor.authorLu, Qen_US
dc.contributor.authorLeung, AMHen_US
dc.contributor.authorZuo, Xen_US
dc.contributor.authorChen, Xen_US
dc.contributor.authorTong, KLen_US
dc.contributor.authorZhou, Fen_US
dc.contributor.authorDiao, Qen_US
dc.contributor.authorTse, NKCen_US
dc.contributor.authorXie, Hen_US
dc.contributor.authorMok, CCen_US
dc.contributor.authorHao, Fen_US
dc.contributor.authorWong, SNen_US
dc.contributor.authorShi, Ben_US
dc.contributor.authorLee, KWen_US
dc.contributor.authorHui, Yen_US
dc.contributor.authorHo, MHKen_US
dc.contributor.authorLiang, Ben_US
dc.contributor.authorLee, PPWen_US
dc.contributor.authorCui, Hen_US
dc.contributor.authorGuo, Qen_US
dc.contributor.authorChung, BHYen_US
dc.contributor.authorPu, Xen_US
dc.contributor.authorLiu, Qen_US
dc.contributor.authorZhang, Xen_US
dc.contributor.authorZhang, Cen_US
dc.contributor.authorChong, CYen_US
dc.contributor.authorFang, Hen_US
dc.contributor.authorWong, RWSen_US
dc.contributor.authorSun, Yen_US
dc.contributor.authorMok, TMYen_US
dc.contributor.authorLi, XPen_US
dc.contributor.authorAvihingsanon, Yen_US
dc.contributor.authorZhi, Zen_US
dc.contributor.authorRianthavorn, Pen_US
dc.contributor.authorDeekajorndej, Ten_US
dc.contributor.authorSuphapeetiporn, Ken_US
dc.contributor.authorGao, Fen_US
dc.contributor.authorShotelersuk, Ven_US
dc.contributor.authorKang, Xen_US
dc.contributor.authorYing, SKYen_US
dc.contributor.authorZhang, Len_US
dc.contributor.authorWong, WHSen_US
dc.contributor.authorZhu, Den_US
dc.contributor.authorFung, SKSen_US
dc.contributor.authorZeng, Fen_US
dc.contributor.authorLai, WMen_US
dc.contributor.authorWong, CMen_US
dc.contributor.authorNg, IOLen_US
dc.contributor.authorGarcia-Barcelo, MMen_US
dc.contributor.authorCherny, SSen_US
dc.contributor.authorShen, Nen_US
dc.contributor.authorTam, PKHen_US
dc.contributor.authorSham, PCen_US
dc.contributor.authorYe, DQen_US
dc.contributor.authorYang, Sen_US
dc.contributor.authorZhang, Xen_US
dc.contributor.authorLau, YLen_US
dc.date.accessioned2013-03-19T03:53:46Z-
dc.date.available2013-03-19T03:53:46Z-
dc.date.issued2013en_US
dc.identifier.citationThe American Journal of Human Genetics, 2013, v. 92, p. 41-51en_US
dc.identifier.issn0002-9297-
dc.identifier.urihttp://hdl.handle.net/10722/181677-
dc.description.abstractSystemic lupus erythematosus (SLE) is a prototype autoimmune disease with a strong genetic involvement and ethnic differences. Susceptibility genes identified so far only explain a small portion of the genetic heritability of SLE, suggesting that many more loci are yet to be uncovered for this disease. In this study, we performed a meta-analysis of genome-wide association studies on SLE in Chinese Han populations and followed up the findings by replication in four additional Asian cohorts with a total of 5,365 cases and 10,054 corresponding controls. We identified genetic variants in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with the disease. These findings point to potential roles of cell-cycle regulation, autophagy, and DNA demethylation in SLE pathogenesis. For the region involving TET3 and that involving CDKN1B, multiple independent SNPs were identified, highlighting a phenomenon that might partially explain the missing heritability of complex diseases. © 2013 The American Society of Human Genetics.-
dc.languageengen_US
dc.relation.ispartofThe American Journal of Human Geneticsen_US
dc.titleMeta-analysis Followed by Replication Identifies Loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as Associated with Systemic Lupus Erythematosus in Asiansen_US
dc.typeArticleen_US
dc.identifier.emailYang, W: yangwl@hkucc.hku.hken_US
dc.identifier.emailZhang, Y: yannizy@hku.hken_US
dc.identifier.emailZheng, J: teddy629@hku.hken_US
dc.identifier.emailYang, J: jingy09@hku.hken_US
dc.identifier.emailZhang, L: zhanglu@hku.hken_US
dc.identifier.emailLee, TL: leetsz@hkucc.hku.hken_US
dc.identifier.emailLau, WCS: cslau@hku.hken_US
dc.identifier.emailYing, D: jonson@hkucc.hku.hken_US
dc.identifier.emailWong, SN: snwong@hkucc.hku.hken_US
dc.identifier.emailHo, MHK: marcoho@hku.hken_US
dc.identifier.emailLee, PPW: ppwlee@hku.hken_US
dc.identifier.emailChung, BHY: bhychung@hku.hken_US
dc.identifier.emailWong, RWS: rwswong@hkucc.hku.hken_US
dc.identifier.emailMok, TMY: temy@hkucc.hku.hken_US
dc.identifier.emailWong, WHS: whswong@hku.hken_US
dc.identifier.emailWong, CM: jackwong@pathology.hku.hken_US
dc.identifier.emailNg, IOL: iolng@hku.hken_US
dc.identifier.emailGarcia-Barcelo, MM: mmgarcia@hku.hken_US
dc.identifier.emailCherny, SS: cherny@hku.hken_US
dc.identifier.emailTam, PKH: paultam@hku.hken_US
dc.identifier.emailSham, PC: pcsham@hku.hken_US
dc.identifier.emailLau, YL: lauylung@hku.hken_US
dc.identifier.authorityYang, W=rp00524en_US
dc.identifier.authorityLau, WCS=rp01348en_US
dc.identifier.authorityLee, PPW=rp00462en_US
dc.identifier.authorityChung, BHY=rp00473en_US
dc.identifier.authorityMok, TMY=rp00490en_US
dc.identifier.authorityWong, CM=rp00231en_US
dc.identifier.authorityNg, IOL=rp00335en_US
dc.identifier.authorityGarcia-Barcelo, MM=rp00445en_US
dc.identifier.authorityCherny, SS=rp00232en_US
dc.identifier.authorityTam, PKH=rp00060en_US
dc.identifier.authoritySham, PC=rp00459en_US
dc.identifier.authorityLau, YL=rp00361en_US
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.ajhg.2012.11.018-
dc.identifier.pmid23273568-
dc.identifier.scopuseid_2-s2.0-84872328824-
dc.identifier.hkuros213592en_US
dc.identifier.volume92en_US
dc.identifier.spage41en_US
dc.identifier.epage51en_US
dc.identifier.isiWOS:000313759000004-

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