File Download
  Links for fulltext
     (May Require Subscription)
  • Find via Find It@HKUL
Supplementary

Conference Paper: High ferritin and low transferrin saturation are associated with pre-diabetes among adults

TitleHigh ferritin and low transferrin saturation are associated with pre-diabetes among adults
Authors
KeywordsCardiovascular disease
Issue Date2012
PublisherHong Kong College of Cardiology. The Journal's web site is located at http://www.hkcchk.com/journals.php#3
Citation
The 16th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine (ICSM 2012), Hong Kong, 17 November 2012. In Journal of the Hong Kong College of Cardiology, 2012, v. 20 n. 2, p. 51, abstract no. OP6 How to Cite?
AbstractBACKGROUND AND AIMS: Iron overload is known to cause diabetes. However, the underlying mechanism is poorly understood. We therefore studied the association of different markers of iron metabolism, namely ferritin, erythrocyte protoporphyrin and transferrin saturation (TSAT, as defined by a percentage of transferrin that is saturated with iron) with pre-diabetes (preDM) in US adults without chronic kidney disease, anemia, and iron deficiency. METHODS: Data on 2,575 participants of the National Health and Nutrition Examination Survey (NHANES) 1999-2002 who were free of diabetes, chronic kidney disease, iron deficiency, and anemia were analyzed. Data on 3,876 participants of the NHANES III (1988-1994) were used as replication. Homeostasis model assessment of insulin resistance (HOMA-IR), blood glycosylated hemoglobin level (A1C), fasting glucose, insulin, and preDM (defined as a fasting plasma glucose 100-125 mg/dl or an A1C value 5.7-6.4%) were measured as the outcomes. RESULTS: Logistic regression analyses indicated independent associations of high ferritin (Ptrend=0.028) and low TSAT (Ptrend=0.029) with preDM after adjusting for sociodemographics, physical activity (active/sedementary), metabolic and inflammatory markers (triglycerides, total cholesterol, HDL cholesterol, mean arterial pressure, CRP, white cell count, and albumin), and liver enzymes (GGT, ALP, AST, and ALT). The NHANES III data showed similar associations. Combining the results showed a more significant association for high ferritin (Pmeta=0.016) and low TSAT (Pmeta=0.002). Moreover, TSAT was associated with A1C, fasting glucose, insulin, and HOMA-IR (Pmeta ≤0.001). CONCLUSIONS: Higher ferritin and lower TSAT are associated with higher risk of preDM in a general population without confounding diseases. Further research is needed to examine the underlying mechanism of these two indices, especially TSAT, in the pathophysiology of preDM.
DescriptionOral Presentation
Young Investigator Award Second Prize
Persistent Identifierhttp://hdl.handle.net/10722/177472
ISSN
2015 SCImago Journal Rankings: 0.102

 

DC FieldValueLanguage
dc.contributor.authorCheung, CLen_US
dc.contributor.authorCheung, TTen_US
dc.contributor.authorLam, KSLen_US
dc.contributor.authorCheung, BMYen_US
dc.date.accessioned2012-12-18T05:12:03Z-
dc.date.available2012-12-18T05:12:03Z-
dc.date.issued2012en_US
dc.identifier.citationThe 16th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine (ICSM 2012), Hong Kong, 17 November 2012. In Journal of the Hong Kong College of Cardiology, 2012, v. 20 n. 2, p. 51, abstract no. OP6en_US
dc.identifier.issn1027-7811-
dc.identifier.urihttp://hdl.handle.net/10722/177472-
dc.descriptionOral Presentation-
dc.descriptionYoung Investigator Award Second Prize-
dc.description.abstractBACKGROUND AND AIMS: Iron overload is known to cause diabetes. However, the underlying mechanism is poorly understood. We therefore studied the association of different markers of iron metabolism, namely ferritin, erythrocyte protoporphyrin and transferrin saturation (TSAT, as defined by a percentage of transferrin that is saturated with iron) with pre-diabetes (preDM) in US adults without chronic kidney disease, anemia, and iron deficiency. METHODS: Data on 2,575 participants of the National Health and Nutrition Examination Survey (NHANES) 1999-2002 who were free of diabetes, chronic kidney disease, iron deficiency, and anemia were analyzed. Data on 3,876 participants of the NHANES III (1988-1994) were used as replication. Homeostasis model assessment of insulin resistance (HOMA-IR), blood glycosylated hemoglobin level (A1C), fasting glucose, insulin, and preDM (defined as a fasting plasma glucose 100-125 mg/dl or an A1C value 5.7-6.4%) were measured as the outcomes. RESULTS: Logistic regression analyses indicated independent associations of high ferritin (Ptrend=0.028) and low TSAT (Ptrend=0.029) with preDM after adjusting for sociodemographics, physical activity (active/sedementary), metabolic and inflammatory markers (triglycerides, total cholesterol, HDL cholesterol, mean arterial pressure, CRP, white cell count, and albumin), and liver enzymes (GGT, ALP, AST, and ALT). The NHANES III data showed similar associations. Combining the results showed a more significant association for high ferritin (Pmeta=0.016) and low TSAT (Pmeta=0.002). Moreover, TSAT was associated with A1C, fasting glucose, insulin, and HOMA-IR (Pmeta ≤0.001). CONCLUSIONS: Higher ferritin and lower TSAT are associated with higher risk of preDM in a general population without confounding diseases. Further research is needed to examine the underlying mechanism of these two indices, especially TSAT, in the pathophysiology of preDM.-
dc.languageengen_US
dc.publisherHong Kong College of Cardiology. The Journal's web site is located at http://www.hkcchk.com/journals.php#3-
dc.relation.ispartofJournal of the Hong Kong College of Cardiologyen_US
dc.subjectCardiovascular disease-
dc.titleHigh ferritin and low transferrin saturation are associated with pre-diabetes among adultsen_US
dc.typeConference_Paperen_US
dc.identifier.emailCheung, CL: lung1212@hku.hken_US
dc.identifier.emailCheung, TT: tcheungt@hku.hken_US
dc.identifier.emailLam, KSL: ksllam@hku.hken_US
dc.identifier.emailCheung, BMY: mycheung@hku.hken_US
dc.identifier.authorityCheung, TT=rp01682en_US
dc.identifier.authorityLam, KSL=rp00343en_US
dc.identifier.authorityCheung, BMY=rp01321en_US
dc.description.naturelink_to_OA_fulltext-
dc.identifier.hkuros212521en_US
dc.identifier.volume20en_US
dc.identifier.issue2en_US
dc.identifier.spage51en_US
dc.identifier.epage51en_US
dc.publisher.placeHong Kong-
dc.description.otherThe 16th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine (ICSM), Hong Kong, 17 November 2012. In Journal of the Hong Kong College of Cardiology, 2012, v. 20 n. 2, p. 51, abstract no. OP6-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats