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Article: Treatment of articulatory dysfunction in Parkinson's disease using repetitive transcranial magnetic stimulation

TitleTreatment of articulatory dysfunction in Parkinson's disease using repetitive transcranial magnetic stimulation
Authors
Issue Date2012
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/ENE
Citation
European Journal Of Neurology, 2012, v. 19 n. 2, p. 340-347 How to Cite?
AbstractBackground and purpose: Neuroimaging has demonstrated that improved speech outcomes in Parkinson's Disease (PD) subsequent to behavioural treatment approaches are associated with increased activity in the motor and pre-motor cortex. High-frequency repetitive transcranial magnetic stimulation (rTMS) is capable of modulating cortical activity and has been reported to have significant benefit to general motor function in PD. It is possible that high-frequency rTMS may also have beneficial outcomes on speech production in PD. Methods: High-frequency (5Hz) rTMS was applied to 10 active stimulation and 10 sham placebo patients for 10min/day (3000 pulses), for 10days and speech outcome measures and lingual kinematic parameters recorded at baseline and 1week, 2 and 12months post-stimulation. Results: The findings demonstrated positive treatment-related changes observed in the active rTMS group when compared to the sham placebo control group at 2 and 12months post-stimulation in speech intelligibility, communication efficiency ratio, maximum velocity of tongue movements and distance of tongue movements. Conclusion: The results support the use of high-frequency rTMS as a therapeutic tool for the treatment of articulatory dysfunction in PD. © 2011 The Author(s). European Journal of Neurology © 2011 EFNS.
Persistent Identifierhttp://hdl.handle.net/10722/175320
ISSN
2015 Impact Factor: 3.956
2015 SCImago Journal Rankings: 1.669
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorMurdoch, BEen_US
dc.contributor.authorNg, MLen_US
dc.contributor.authorBarwood, CHSen_US
dc.date.accessioned2012-11-26T08:58:10Z-
dc.date.available2012-11-26T08:58:10Z-
dc.date.issued2012en_US
dc.identifier.citationEuropean Journal Of Neurology, 2012, v. 19 n. 2, p. 340-347en_US
dc.identifier.issn1351-5101en_US
dc.identifier.urihttp://hdl.handle.net/10722/175320-
dc.description.abstractBackground and purpose: Neuroimaging has demonstrated that improved speech outcomes in Parkinson's Disease (PD) subsequent to behavioural treatment approaches are associated with increased activity in the motor and pre-motor cortex. High-frequency repetitive transcranial magnetic stimulation (rTMS) is capable of modulating cortical activity and has been reported to have significant benefit to general motor function in PD. It is possible that high-frequency rTMS may also have beneficial outcomes on speech production in PD. Methods: High-frequency (5Hz) rTMS was applied to 10 active stimulation and 10 sham placebo patients for 10min/day (3000 pulses), for 10days and speech outcome measures and lingual kinematic parameters recorded at baseline and 1week, 2 and 12months post-stimulation. Results: The findings demonstrated positive treatment-related changes observed in the active rTMS group when compared to the sham placebo control group at 2 and 12months post-stimulation in speech intelligibility, communication efficiency ratio, maximum velocity of tongue movements and distance of tongue movements. Conclusion: The results support the use of high-frequency rTMS as a therapeutic tool for the treatment of articulatory dysfunction in PD. © 2011 The Author(s). European Journal of Neurology © 2011 EFNS.en_US
dc.languageengen_US
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/ENEen_US
dc.relation.ispartofEuropean Journal of Neurologyen_US
dc.subject.meshAgeden_US
dc.subject.meshDouble-Blind Methoden_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshMotor Cortex - Physiopathologyen_US
dc.subject.meshParkinson Disease - Complications - Physiopathology - Therapyen_US
dc.subject.meshSpeech Disorders - Etiology - Physiopathology - Therapyen_US
dc.subject.meshSpeech Intelligibility - Physiologyen_US
dc.subject.meshTranscranial Magnetic Stimulation - Methodsen_US
dc.subject.meshTreatment Outcomeen_US
dc.titleTreatment of articulatory dysfunction in Parkinson's disease using repetitive transcranial magnetic stimulationen_US
dc.typeArticleen_US
dc.identifier.emailNg, ML: manwa@hku.hken_US
dc.identifier.authorityNg, ML=rp00942en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1468-1331.2011.03524.xen_US
dc.identifier.pmid21967191-
dc.identifier.scopuseid_2-s2.0-84856040996en_US
dc.identifier.hkuros203330-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84856040996&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume19en_US
dc.identifier.issue2en_US
dc.identifier.spage340en_US
dc.identifier.epage347en_US
dc.identifier.eissn1468-1331-
dc.identifier.isiWOS:000299255300028-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridMurdoch, BE=7005161745en_US
dc.identifier.scopusauthoridNg, ML=15923631600en_US
dc.identifier.scopusauthoridBarwood, CHS=23567756000en_US

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