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Article: A combination of chemoirradiation and chemotherapy for treatment of advanced clear cell adenocarcinoma of the cervix

TitleA combination of chemoirradiation and chemotherapy for treatment of advanced clear cell adenocarcinoma of the cervix
Authors
Issue Date2008
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.ijgc.net/
Citation
International Journal Of Gynecological Cancer, 2008, v. 18 n. 3, p. 559-563 How to Cite?
AbstractClear cell adenocarcinoma of the cervix (CCAC) is an uncommon tumor. No good treatment option has been reported for advanced disease, and the prognosis is generally poor. We report a case of a 14-year-old girl with stage III CCAC. She was given whole-pelvic external irradiation (40 Gy in 20 daily fractions) and high-dose rate brachytherapy with concurrent weekly cisplatin (40 mg/m 2), followed by further external irradiation to the parametria with central shield (14 Gy in seven daily fractions). She then received one cycle of carboplatin (area under the curve [AUC] 6) with paclitaxel (175 mg/m 2) and two cycles of carboplatin (AUC 4) with gemcitabine (1000 mg/m2 on days 1 and 8) because she developed anaphylactic shock to paclitaxel. Chemotherapy was stopped after the third cycle due to initial poor general condition. However, she gradually improved while on palliative care. Reassessment 6 months later showed no evidence of residual disease, and she remained disease free during a follow-up of 1 year. The complete response in this case suggests that chemoirradiation followed by combination chemotherapy may be a treatment option for advanced CCAC. © 2007, Copyright the Authors.
Persistent Identifierhttp://hdl.handle.net/10722/173332
ISSN
2015 Impact Factor: 2.116
2015 SCImago Journal Rankings: 0.830
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChan, KKLen_US
dc.contributor.authorIp, Pen_US
dc.contributor.authorKwong, Pen_US
dc.contributor.authorTam, KFen_US
dc.contributor.authorNgan, HYSen_US
dc.date.accessioned2012-10-30T06:29:23Z-
dc.date.available2012-10-30T06:29:23Z-
dc.date.issued2008en_US
dc.identifier.citationInternational Journal Of Gynecological Cancer, 2008, v. 18 n. 3, p. 559-563en_US
dc.identifier.issn1048-891Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/173332-
dc.description.abstractClear cell adenocarcinoma of the cervix (CCAC) is an uncommon tumor. No good treatment option has been reported for advanced disease, and the prognosis is generally poor. We report a case of a 14-year-old girl with stage III CCAC. She was given whole-pelvic external irradiation (40 Gy in 20 daily fractions) and high-dose rate brachytherapy with concurrent weekly cisplatin (40 mg/m 2), followed by further external irradiation to the parametria with central shield (14 Gy in seven daily fractions). She then received one cycle of carboplatin (area under the curve [AUC] 6) with paclitaxel (175 mg/m 2) and two cycles of carboplatin (AUC 4) with gemcitabine (1000 mg/m2 on days 1 and 8) because she developed anaphylactic shock to paclitaxel. Chemotherapy was stopped after the third cycle due to initial poor general condition. However, she gradually improved while on palliative care. Reassessment 6 months later showed no evidence of residual disease, and she remained disease free during a follow-up of 1 year. The complete response in this case suggests that chemoirradiation followed by combination chemotherapy may be a treatment option for advanced CCAC. © 2007, Copyright the Authors.en_US
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.ijgc.net/en_US
dc.relation.ispartofInternational Journal of Gynecological Canceren_US
dc.subject.meshAdenocarcinoma, Clear Cell - Drug Therapy - Pathology - Radiotherapyen_US
dc.subject.meshAdulten_US
dc.subject.meshAntineoplastic Combined Chemotherapy Protocols - Administration & Dosageen_US
dc.subject.meshBiopsy, Needleen_US
dc.subject.meshBrachytherapy - Methodsen_US
dc.subject.meshCombined Modality Therapyen_US
dc.subject.meshFemaleen_US
dc.subject.meshFollow-Up Studiesen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunohistochemistryen_US
dc.subject.meshNeoplasm Invasiveness - Pathologyen_US
dc.subject.meshNeoplasm Stagingen_US
dc.subject.meshRare Diseasesen_US
dc.subject.meshRisk Assessmenten_US
dc.subject.meshTreatment Outcomeen_US
dc.subject.meshUterine Cervical Neoplasms - Drug Therapy - Pathology - Radiotherapyen_US
dc.titleA combination of chemoirradiation and chemotherapy for treatment of advanced clear cell adenocarcinoma of the cervixen_US
dc.typeArticleen_US
dc.identifier.emailChan, KKL:kklchan@hkucc.hku.hken_US
dc.identifier.emailNgan, HYS:hysngan@hkucc.hku.hken_US
dc.identifier.authorityChan, KKL=rp00499en_US
dc.identifier.authorityNgan, HYS=rp00346en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1525-1438.2007.01037.xen_US
dc.identifier.pmid17692092-
dc.identifier.scopuseid_2-s2.0-43449120948en_US
dc.identifier.hkuros145335-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-43449120948&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume18en_US
dc.identifier.issue3en_US
dc.identifier.spage559en_US
dc.identifier.epage563en_US
dc.identifier.isiWOS:000256055200027-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridChan, KKL=8655666700en_US
dc.identifier.scopusauthoridIp, P=7003622683en_US
dc.identifier.scopusauthoridKwong, P=7006992418en_US
dc.identifier.scopusauthoridTam, KF=7201692816en_US
dc.identifier.scopusauthoridNgan, HYS=34571944100en_US
dc.identifier.citeulike2792290-

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