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Article: Maternal serum pregnancy-associated plasma protein-A and free β-human chorionic gonadotrophin in pregnancies conceived with fresh and frozen-thawed embryos from in vitro fertilization and intracytoplasmic sperm injection

TitleMaternal serum pregnancy-associated plasma protein-A and free β-human chorionic gonadotrophin in pregnancies conceived with fresh and frozen-thawed embryos from in vitro fertilization and intracytoplasmic sperm injection
Authors
KeywordsFET
hCG
ICSI
IVF
PAPP-A
Issue Date2005
PublisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/2252
Citation
Prenatal Diagnosis, 2005, v. 25 n. 5, p. 390-393 How to Cite?
AbstractObjective: Maternal serum pregnancy-associated plasma protein-A (PAPP-A) and free β-human chorionic gonadotrophin (β-hCG) are useful markers in the screening of Down syndrome in the first trimester. We investigated the effect of intracytoplasmic sperm injection (ICSI), freezing and thawing of embryos on the levels of these two analytes in assisted reproduction pregnancies. Methods: We recruited 149 women who conceived after assisted reproduction with fresh embryos (92 from conventional IVF and 57 from ICSI), 85 women who conceived with frozen-thawed embryos (54 from conventional IVF and 31 from ICSI) and 401 women with spontaneous conceptions as controls. The concentrations of PAPP-A and free β-hCG were measured between 10 and 14 weeks and were converted to multiples of medians (MoM) for comparisons. Results: Median PAPP-A MoMs were significantly reduced in ICSI pregnancies in the fresh and frozen-thawed embryo subgroups (0.70 and 0.66 MoM respectively) and in the IVF fresh embryo subgroups (0.83 MoM), as compared to controls (1.00 MoM). Free β-hCG MoM was significantly reduced in the IVF fresh embryos subgroup (0.87 MoM), but not in the other three subgroups. Conclusion: Further studies for exploring the underlying pathophysiology and adjustment in the marker levels for screening of Down syndrome are warranted in pregnancies conceived after assisted reproduction. Copyright © 2005 John Wiley & Sons, Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/173287
ISSN
2015 Impact Factor: 3.043
2015 SCImago Journal Rankings: 1.450
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorHui, PWen_HK
dc.contributor.authorLam, YHen_HK
dc.contributor.authorTang, MHYen_HK
dc.contributor.authorNg, EHYen_HK
dc.contributor.authorYeung, WSBen_HK
dc.contributor.authorHo, PCen_HK
dc.date.accessioned2012-10-30T06:29:06Z-
dc.date.available2012-10-30T06:29:06Z-
dc.date.issued2005en_HK
dc.identifier.citationPrenatal Diagnosis, 2005, v. 25 n. 5, p. 390-393en_HK
dc.identifier.issn0197-3851en_HK
dc.identifier.urihttp://hdl.handle.net/10722/173287-
dc.description.abstractObjective: Maternal serum pregnancy-associated plasma protein-A (PAPP-A) and free β-human chorionic gonadotrophin (β-hCG) are useful markers in the screening of Down syndrome in the first trimester. We investigated the effect of intracytoplasmic sperm injection (ICSI), freezing and thawing of embryos on the levels of these two analytes in assisted reproduction pregnancies. Methods: We recruited 149 women who conceived after assisted reproduction with fresh embryos (92 from conventional IVF and 57 from ICSI), 85 women who conceived with frozen-thawed embryos (54 from conventional IVF and 31 from ICSI) and 401 women with spontaneous conceptions as controls. The concentrations of PAPP-A and free β-hCG were measured between 10 and 14 weeks and were converted to multiples of medians (MoM) for comparisons. Results: Median PAPP-A MoMs were significantly reduced in ICSI pregnancies in the fresh and frozen-thawed embryo subgroups (0.70 and 0.66 MoM respectively) and in the IVF fresh embryo subgroups (0.83 MoM), as compared to controls (1.00 MoM). Free β-hCG MoM was significantly reduced in the IVF fresh embryos subgroup (0.87 MoM), but not in the other three subgroups. Conclusion: Further studies for exploring the underlying pathophysiology and adjustment in the marker levels for screening of Down syndrome are warranted in pregnancies conceived after assisted reproduction. Copyright © 2005 John Wiley & Sons, Ltd.en_HK
dc.languageengen_US
dc.publisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/2252en_HK
dc.relation.ispartofPrenatal Diagnosisen_HK
dc.rightsPrenatal Diagnosis. Copyright © John Wiley & Sons Ltd.-
dc.subjectFETen_HK
dc.subjecthCGen_HK
dc.subjectICSIen_HK
dc.subjectIVFen_HK
dc.subjectPAPP-Aen_HK
dc.subject.meshAdulten_US
dc.subject.meshBiological Markers - Blooden_US
dc.subject.meshCase-Control Studiesen_US
dc.subject.meshChorionic Gonadotropin, Beta Subunit, Human - Blooden_US
dc.subject.meshCryopreservationen_US
dc.subject.meshDown Syndrome - Blood - Diagnosisen_US
dc.subject.meshEmbryo, Mammalianen_US
dc.subject.meshFemaleen_US
dc.subject.meshFertilization In Vitroen_US
dc.subject.meshHumansen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPredictive Value Of Testsen_US
dc.subject.meshPregnancy - Blooden_US
dc.subject.meshPregnancy Trimester, First - Blooden_US
dc.subject.meshPregnancy-Associated Plasma Protein-A - Metabolismen_US
dc.subject.meshPrenatal Diagnosisen_US
dc.subject.meshSperm Injections, Intracytoplasmicen_US
dc.titleMaternal serum pregnancy-associated plasma protein-A and free β-human chorionic gonadotrophin in pregnancies conceived with fresh and frozen-thawed embryos from in vitro fertilization and intracytoplasmic sperm injectionen_HK
dc.typeArticleen_HK
dc.identifier.emailTang, MHY: mhytang@hkucc.hku.hken_HK
dc.identifier.emailNg, EHY: nghye@hku.hken_HK
dc.identifier.emailYeung, WSB: wsbyeung@hkucc.hku.hken_HK
dc.identifier.emailHo, PC: pcho@hku.hken_HK
dc.identifier.authorityTang, MHY=rp01701en_HK
dc.identifier.authorityNg, EHY=rp00426en_HK
dc.identifier.authorityYeung, WSB=rp00331en_HK
dc.identifier.authorityHo, PC=rp00325en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/pd.1169en_HK
dc.identifier.pmid15906430en_HK
dc.identifier.scopuseid_2-s2.0-20444459752en_HK
dc.identifier.hkuros98991-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-20444459752&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume25en_HK
dc.identifier.issue5en_HK
dc.identifier.spage390en_HK
dc.identifier.epage393en_HK
dc.identifier.isiWOS:000229517700010-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridHui, PW=7101621830en_HK
dc.identifier.scopusauthoridLam, YH=7202563903en_HK
dc.identifier.scopusauthoridTang, MHY=8943401300en_HK
dc.identifier.scopusauthoridNg, EHY=35238184300en_HK
dc.identifier.scopusauthoridYeung, WSB=7102370745en_HK
dc.identifier.scopusauthoridHo, PC=7402211440en_HK

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