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Article: New insights into the mechanisms underlying hydrosalpinx fluid formation and its adverse effect on IVF outcome

TitleNew insights into the mechanisms underlying hydrosalpinx fluid formation and its adverse effect on IVF outcome
Authors
KeywordsCFTR
Chlamydial infection
Hydrosalpinx
IVF
Issue Date2002
PublisherOxford University Press. The Journal's web site is located at http://humupd.oxfordjournals.org
Citation
Human Reproduction Update, 2002, v. 8 n. 3, p. 255-264 How to Cite?
AbstractThe adverse effects of hydrosalpinx on the outcome of IVF have been well documented; however, the causes for impaired implantation in patients with hydrosalpinx are poorly understood. Hydrosalpinx fluid has been shown to be toxic to mouse embryos but not human embryos, and this has become a topic of intense debate. An understanding of the mechanisms underlying hydrosalpinx formation following pelvic inflammatory disease appears to be essential in elucidating the causes for reduced implantation in hydrosalpinx patients and providing more rational treatments. This review discusses the mechanisms underlying hydrosalpinx formation and its adverse effect on IVF outcome, with new insights into possible involvement of Fallopian tube epithelial transporters and ion channels, particularly the cystic fibrosis transmembrane conductance regulator (CFTR). Possible links between Chlamydia trachomatis in pelvic inflammatory disease and the subsequent CFTR-mediated events in hydrosalpinx formation leading to infertility in hydrosalpinx are proposed. The causes of reduced implantation, particularly in patients with visible hydrosalpinges shown on ultrasound scanning, are re-examined in light of these possible mechanisms.
Persistent Identifierhttp://hdl.handle.net/10722/173262
ISSN
2015 Impact Factor: 11.194
2015 SCImago Journal Rankings: 4.678
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorAjonuma, LCen_HK
dc.contributor.authorNg, EHYen_HK
dc.contributor.authorChan, HCen_HK
dc.date.accessioned2012-10-30T06:28:52Z-
dc.date.available2012-10-30T06:28:52Z-
dc.date.issued2002en_HK
dc.identifier.citationHuman Reproduction Update, 2002, v. 8 n. 3, p. 255-264en_HK
dc.identifier.issn1355-4786en_HK
dc.identifier.urihttp://hdl.handle.net/10722/173262-
dc.description.abstractThe adverse effects of hydrosalpinx on the outcome of IVF have been well documented; however, the causes for impaired implantation in patients with hydrosalpinx are poorly understood. Hydrosalpinx fluid has been shown to be toxic to mouse embryos but not human embryos, and this has become a topic of intense debate. An understanding of the mechanisms underlying hydrosalpinx formation following pelvic inflammatory disease appears to be essential in elucidating the causes for reduced implantation in hydrosalpinx patients and providing more rational treatments. This review discusses the mechanisms underlying hydrosalpinx formation and its adverse effect on IVF outcome, with new insights into possible involvement of Fallopian tube epithelial transporters and ion channels, particularly the cystic fibrosis transmembrane conductance regulator (CFTR). Possible links between Chlamydia trachomatis in pelvic inflammatory disease and the subsequent CFTR-mediated events in hydrosalpinx formation leading to infertility in hydrosalpinx are proposed. The causes of reduced implantation, particularly in patients with visible hydrosalpinges shown on ultrasound scanning, are re-examined in light of these possible mechanisms.en_HK
dc.languageengen_US
dc.publisherOxford University Press. The Journal's web site is located at http://humupd.oxfordjournals.orgen_HK
dc.relation.ispartofHuman Reproduction Updateen_HK
dc.subjectCFTRen_HK
dc.subjectChlamydial infectionen_HK
dc.subjectHydrosalpinxen_HK
dc.subjectIVFen_HK
dc.subject.meshChlamydia Infections - Complications - Physiopathologyen_US
dc.subject.meshFallopian Tube Diseases - Physiopathologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshFertilization In Vitro - Adverse Effects - Methodsen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshPregnancyen_US
dc.subject.meshPregnancy Outcomeen_US
dc.titleNew insights into the mechanisms underlying hydrosalpinx fluid formation and its adverse effect on IVF outcomeen_HK
dc.typeArticleen_HK
dc.identifier.emailAjonuma, LC: louisca@hkucc.hku.hken_HK
dc.identifier.emailNg, EHY: nghye@hku.hken_HK
dc.identifier.authorityAjonuma, LC=rp00051en_HK
dc.identifier.authorityNg, EHY=rp00426en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1093/humupd/8.3.255en_HK
dc.identifier.pmid12078836-
dc.identifier.scopuseid_2-s2.0-0036562354en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0036562354&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume8en_HK
dc.identifier.issue3en_HK
dc.identifier.spage255en_HK
dc.identifier.epage264en_HK
dc.identifier.isiWOS:000176189500005-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridAjonuma, LC=6602292557en_HK
dc.identifier.scopusauthoridNg, EHY=35238184300en_HK
dc.identifier.scopusauthoridChan, HC=7403402737en_HK

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