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Article: A comparative study of Y chromosome microdeletions in infertile males from two Chinese populations

TitleA comparative study of Y chromosome microdeletions in infertile males from two Chinese populations
Authors
Issue Date2002
PublisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=1058-0468
Citation
Journal Of Assisted Reproduction And Genetics, 2002, v. 19 n. 8, p. 376-383 How to Cite?
AbstractPurpose: To compare the prevalence and type of Y-microdeletions in Hong Kong and Shanghai men with severe male-factor infertility. Methods: Seven Y-linked sequence tagged site (STS) primers and seven gene-specific primers were screened in 293 infertile males (139 from Hong Kong and 154 from Shanghai) and 161 fertile men (61 from Hong Kong and 100 from Shanghai). Serum FSH, LH, and testosterone levels were also measured in these men. Results: The incidence of Yq microdeletions in nonobstructive azoospermic men from Hong Kong (8.5%) and Shanghai (6%) was similar. Yq microdeletions were observed in severe oligospermic patients (8.5%) from Hong Kong but not from Shanghai. Among the 9 Hong Kong men with Y-microdeletions, 8 had AZFc deletion and one had AZFb deletion. In contrast, 6 of 9 men from Shanghai with Y-microdeletions had AZFb deletion. The incidence of AZFb deletion among Y-microdeleted men was statistically different between the two populations. Two of the men with AZFb deletion also had AZFa and AZFc deletions. Conclusions: Regional variations in the type of Y-microdeletion existed between Hong Kong and Shanghai infertile males.
Persistent Identifierhttp://hdl.handle.net/10722/173257
ISSN
2015 Impact Factor: 1.858
2015 SCImago Journal Rankings: 0.858
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorTse, JYMen_US
dc.contributor.authorYeung, WSBen_US
dc.contributor.authorNg, EHYen_US
dc.contributor.authorCheng, LNen_US
dc.contributor.authorZhu, HBen_US
dc.contributor.authorTeng, XMen_US
dc.contributor.authorLiu, YKen_US
dc.contributor.authorHo, PCen_US
dc.date.accessioned2012-10-30T06:28:51Z-
dc.date.available2012-10-30T06:28:51Z-
dc.date.issued2002en_US
dc.identifier.citationJournal Of Assisted Reproduction And Genetics, 2002, v. 19 n. 8, p. 376-383en_US
dc.identifier.issn1058-0468en_US
dc.identifier.urihttp://hdl.handle.net/10722/173257-
dc.description.abstractPurpose: To compare the prevalence and type of Y-microdeletions in Hong Kong and Shanghai men with severe male-factor infertility. Methods: Seven Y-linked sequence tagged site (STS) primers and seven gene-specific primers were screened in 293 infertile males (139 from Hong Kong and 154 from Shanghai) and 161 fertile men (61 from Hong Kong and 100 from Shanghai). Serum FSH, LH, and testosterone levels were also measured in these men. Results: The incidence of Yq microdeletions in nonobstructive azoospermic men from Hong Kong (8.5%) and Shanghai (6%) was similar. Yq microdeletions were observed in severe oligospermic patients (8.5%) from Hong Kong but not from Shanghai. Among the 9 Hong Kong men with Y-microdeletions, 8 had AZFc deletion and one had AZFb deletion. In contrast, 6 of 9 men from Shanghai with Y-microdeletions had AZFb deletion. The incidence of AZFb deletion among Y-microdeleted men was statistically different between the two populations. Two of the men with AZFb deletion also had AZFa and AZFc deletions. Conclusions: Regional variations in the type of Y-microdeletion existed between Hong Kong and Shanghai infertile males.en_US
dc.languageengen_US
dc.publisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=1058-0468en_US
dc.relation.ispartofJournal of Assisted Reproduction and Geneticsen_US
dc.subject.meshAdulten_US
dc.subject.meshChina - Epidemiologyen_US
dc.subject.meshChromosome Deletionen_US
dc.subject.meshChromosomes, Human, Y - Geneticsen_US
dc.subject.meshDna - Chemistry - Geneticsen_US
dc.subject.meshFollicle Stimulating Hormone - Blooden_US
dc.subject.meshHumansen_US
dc.subject.meshInfertility, Male - Epidemiology - Geneticsen_US
dc.subject.meshLuteinizing Hormone - Blooden_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshOligospermia - Epidemiology - Geneticsen_US
dc.subject.meshPolymerase Chain Reactionen_US
dc.subject.meshSequence Tagged Sitesen_US
dc.subject.meshSex Chromosome Aberrationsen_US
dc.subject.meshTestosterone - Blooden_US
dc.titleA comparative study of Y chromosome microdeletions in infertile males from two Chinese populationsen_US
dc.typeArticleen_US
dc.identifier.emailYeung, WSB:wsbyeung@hkucc.hku.hken_US
dc.identifier.emailNg, EHY:nghye@hkucc.hku.hken_US
dc.identifier.emailHo, PC:pcho@hku.hken_US
dc.identifier.authorityYeung, WSB=rp00331en_US
dc.identifier.authorityNg, EHY=rp00426en_US
dc.identifier.authorityHo, PC=rp00325en_US
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1023/A:1016346421177en_US
dc.identifier.pmid12182444-
dc.identifier.pmcidPMC3455580-
dc.identifier.scopuseid_2-s2.0-0035988605en_US
dc.identifier.hkuros82757-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0035988605&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume19en_US
dc.identifier.issue8en_US
dc.identifier.spage376en_US
dc.identifier.epage383en_US
dc.identifier.isiWOS:000176812800004-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridTse, JYM=7102607314en_US
dc.identifier.scopusauthoridYeung, WSB=7102370745en_US
dc.identifier.scopusauthoridNg, EHY=35238184300en_US
dc.identifier.scopusauthoridCheng, LN=34869443100en_US
dc.identifier.scopusauthoridZhu, HB=37109922200en_US
dc.identifier.scopusauthoridTeng, XM=36884037200en_US
dc.identifier.scopusauthoridLiu, YK=7410221026en_US
dc.identifier.scopusauthoridHo, PC=7402211440en_US

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