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Article: Estrogen and progesterone receptors in normal cervix and primary cervical carcinoma

TitleEstrogen and progesterone receptors in normal cervix and primary cervical carcinoma
子宮頸癌和正常宮頸組織雌、孕激素受體的研究
Authors
Issue Date1994
Citation
Chinese journal of obstetrics and gynecology, 1994, v. 29 n. 5, p. 284-288, 317-318 How to Cite?
中華婦產科雜誌, 1994, v. 29 n. 5, p. 284-288, 317-318 How to Cite?
AbstractEstrogen and progesterone receptor levels (ER and PR) were measured in 21 specimens of cervical carcinoma and in 17 normal cervix by monoclonal enzyme immunoassay (ER-EIA and PR-EIA). In normal cervix, 88.2% of specimens were ER-positive (more than 15 fmol/mg protein), 74.5% were PR-positive (more than 15 fmol/mg protein) and 74.5% were both ER and PR-positive. In cervical cancer, 66.7% of malignancies were ER-positive, 42.9% were PR-positive and 38.1% were both ER and PR-positive. There was no significant difference in ER status between the normal cervix and cervical cancer (P > 0.05), but PR status and levels in normal cervix were significantly higher than those in cervical carcinoma (P < 0.05). ER levels in squamous cell carcinoma was not correlated to the tumor stage, histologic grade and menopausal status. PR levels in premenopausal patients with squamous cell carcinoma were significantly higher than those in postmenopausal patients (P < 0.01). Adenocarcinoma of the cervix contained significantly more ER and PR than squamous cell carcinoma (P < 0.01, P < 0.05). In addition, serum E2 level was also assayed in 21 patients with cervical cancer. There was significant difference in E2 levels between the premenopausal and postmenopausal patients (P < 0.01). Patients were stratified according to E2 levels, a significant difference in PR level and in ratio of PR/ER was noted (P < 0.05, P < 0.01).
采用單克隆酶聯免疫測定法,檢測了21例宮頸癌(宮頸癌組)和17例正常宮頸肌層纖維組織(正常組)的雌、孕激素受體水平。結果:正常組雌激素受體(ER)的陽性率為88.2%,孕激素受體(PR)的陽性率為74.5%,ER和PR均陽性者占74.5%。宮頸癌組ER陽性率為66.7%,PR陽性率為42.9%,ER和PR均陽性者占38.1%。兩組ER狀態和水平比較,差異無顯著意義(P>0.05),但宮頸癌組的Pk陽性率和PR水平均明顯低于正常組(P<0.05)。宮頸癌組織的ER和PR水平與腫瘤分期,組織學分級之間,差異無顯著意義(P>0.05)。絕經前宮頸癌組織PR水平較絕經后明顯升高。宮頸腺癌組織ER和PR水平均明顯高于宮頸鱗癌。宮頸癌患者按血清雌二醇水平高低分組,PR水平和PR/ER比值比較,差異均有顯著意義。
Persistent Identifierhttp://hdl.handle.net/10722/173206
ISSN
2015 SCImago Journal Rankings: 0.168

 

DC FieldValueLanguage
dc.contributor.authorShen, Ken_US
dc.contributor.authorYueng, Wen_US
dc.contributor.authorNgan, Hen_US
dc.date.accessioned2012-10-30T06:28:31Z-
dc.date.available2012-10-30T06:28:31Z-
dc.date.issued1994en_US
dc.identifier.citationChinese journal of obstetrics and gynecology, 1994, v. 29 n. 5, p. 284-288, 317-318en_US
dc.identifier.citation中華婦產科雜誌, 1994, v. 29 n. 5, p. 284-288, 317-318-
dc.identifier.issn0529-567Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/173206-
dc.description.abstractEstrogen and progesterone receptor levels (ER and PR) were measured in 21 specimens of cervical carcinoma and in 17 normal cervix by monoclonal enzyme immunoassay (ER-EIA and PR-EIA). In normal cervix, 88.2% of specimens were ER-positive (more than 15 fmol/mg protein), 74.5% were PR-positive (more than 15 fmol/mg protein) and 74.5% were both ER and PR-positive. In cervical cancer, 66.7% of malignancies were ER-positive, 42.9% were PR-positive and 38.1% were both ER and PR-positive. There was no significant difference in ER status between the normal cervix and cervical cancer (P > 0.05), but PR status and levels in normal cervix were significantly higher than those in cervical carcinoma (P < 0.05). ER levels in squamous cell carcinoma was not correlated to the tumor stage, histologic grade and menopausal status. PR levels in premenopausal patients with squamous cell carcinoma were significantly higher than those in postmenopausal patients (P < 0.01). Adenocarcinoma of the cervix contained significantly more ER and PR than squamous cell carcinoma (P < 0.01, P < 0.05). In addition, serum E2 level was also assayed in 21 patients with cervical cancer. There was significant difference in E2 levels between the premenopausal and postmenopausal patients (P < 0.01). Patients were stratified according to E2 levels, a significant difference in PR level and in ratio of PR/ER was noted (P < 0.05, P < 0.01).en_US
dc.description.abstract采用單克隆酶聯免疫測定法,檢測了21例宮頸癌(宮頸癌組)和17例正常宮頸肌層纖維組織(正常組)的雌、孕激素受體水平。結果:正常組雌激素受體(ER)的陽性率為88.2%,孕激素受體(PR)的陽性率為74.5%,ER和PR均陽性者占74.5%。宮頸癌組ER陽性率為66.7%,PR陽性率為42.9%,ER和PR均陽性者占38.1%。兩組ER狀態和水平比較,差異無顯著意義(P>0.05),但宮頸癌組的Pk陽性率和PR水平均明顯低于正常組(P<0.05)。宮頸癌組織的ER和PR水平與腫瘤分期,組織學分級之間,差異無顯著意義(P>0.05)。絕經前宮頸癌組織PR水平較絕經后明顯升高。宮頸腺癌組織ER和PR水平均明顯高于宮頸鱗癌。宮頸癌患者按血清雌二醇水平高低分組,PR水平和PR/ER比值比較,差異均有顯著意義。-
dc.languagechien_US
dc.relation.ispartofChinese journal of obstetrics and gynecologyen_US
dc.relation.ispartof中華婦產科雜誌-
dc.subject.meshAdenocarcinoma - Chemistryen_US
dc.subject.meshAdulten_US
dc.subject.meshCarcinoma, Squamous Cell - Chemistryen_US
dc.subject.meshCervix Uteri - Chemistryen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunoenzyme Techniquesen_US
dc.subject.meshMenopause - Metabolismen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshReceptors, Estrogen - Analysisen_US
dc.subject.meshReceptors, Progesterone - Analysisen_US
dc.subject.meshUterine Cervical Neoplasms - Chemistryen_US
dc.titleEstrogen and progesterone receptors in normal cervix and primary cervical carcinomaen_US
dc.title子宮頸癌和正常宮頸組織雌、孕激素受體的研究-
dc.typeArticleen_US
dc.identifier.emailNgan, H:hysngan@hkucc.hku.hken_US
dc.identifier.authorityNgan, H=rp00346en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid7956553-
dc.identifier.scopuseid_2-s2.0-0028433282en_US
dc.identifier.volume29en_US
dc.identifier.issue5en_US
dc.identifier.spage284en_US
dc.identifier.epage288, 317-318en_US
dc.identifier.scopusauthoridShen, K=7201458163en_US
dc.identifier.scopusauthoridYueng, W=6505886107en_US
dc.identifier.scopusauthoridNgan, H=34571944100en_US
dc.customcontrol.immutablecsl 150116-

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