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Article: An evaluation of the prognostic factors in metastatic gestational trophoblastic disease

TitleAn evaluation of the prognostic factors in metastatic gestational trophoblastic disease
Authors
Issue Date1994
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.ijgc.net/
Citation
International Journal Of Gynecological Cancer, 1994, v. 4 n. 1, p. 36-42 How to Cite?
AbstractA retrospective evaluation of prognostic factors in 55 patients suffering from metastatic gestational trophoblastic disease (MGTD) treated by modified Bagshawe's CHAMOCA regimen was done. The prognostic significance of the eight prognostic factors in the WHO scoring system, number of sites of metastasis and FIGO staging were evaluated by univariate analysis using Chi-square test with Yates' correction and odds ratio and by multivariate analysis using Cox proportional hazard analysis and logistic regression analysis. In the univariate analysis, the intervals between antecedent pregnancy and the diagnosis of GTD, (P = 0.004) the level of hCG (P = 0.02) and the number of metastatic sites (P = 0.046) were significantly associated with death. In the multivariate analysis, only the interval between the antecedent pregnancy and the diagnosis and the level of hCG were significantly associated with death. Thus, it seems that the interval between antecedant pregnancy and the diagnosis and the level of hCG were the two most significant factors in predicting mortality in high risk MGTD. The WHO staging was more predictive of poor outcome than that of the FIGO staging in this group of patients.
Persistent Identifierhttp://hdl.handle.net/10722/173202
ISSN
2015 Impact Factor: 2.116
2015 SCImago Journal Rankings: 0.830
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorNgan, HYSen_US
dc.contributor.authorLopes, ADBen_US
dc.contributor.authorLauder, IJen_US
dc.contributor.authorMartin, BHen_US
dc.contributor.authorWong, LCen_US
dc.contributor.authorMa, HKen_US
dc.date.accessioned2012-10-30T06:28:30Z-
dc.date.available2012-10-30T06:28:30Z-
dc.date.issued1994en_US
dc.identifier.citationInternational Journal Of Gynecological Cancer, 1994, v. 4 n. 1, p. 36-42en_US
dc.identifier.issn1048-891Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/173202-
dc.description.abstractA retrospective evaluation of prognostic factors in 55 patients suffering from metastatic gestational trophoblastic disease (MGTD) treated by modified Bagshawe's CHAMOCA regimen was done. The prognostic significance of the eight prognostic factors in the WHO scoring system, number of sites of metastasis and FIGO staging were evaluated by univariate analysis using Chi-square test with Yates' correction and odds ratio and by multivariate analysis using Cox proportional hazard analysis and logistic regression analysis. In the univariate analysis, the intervals between antecedent pregnancy and the diagnosis of GTD, (P = 0.004) the level of hCG (P = 0.02) and the number of metastatic sites (P = 0.046) were significantly associated with death. In the multivariate analysis, only the interval between the antecedent pregnancy and the diagnosis and the level of hCG were significantly associated with death. Thus, it seems that the interval between antecedant pregnancy and the diagnosis and the level of hCG were the two most significant factors in predicting mortality in high risk MGTD. The WHO staging was more predictive of poor outcome than that of the FIGO staging in this group of patients.en_US
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.ijgc.net/en_US
dc.relation.ispartofInternational Journal of Gynecological Canceren_US
dc.titleAn evaluation of the prognostic factors in metastatic gestational trophoblastic diseaseen_US
dc.typeArticleen_US
dc.identifier.emailNgan, HYS:hysngan@hkucc.hku.hken_US
dc.identifier.authorityNgan, HYS=rp00346en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1046/j.1525-1438.1994.04010036.xen_US
dc.identifier.scopuseid_2-s2.0-0028157058en_US
dc.identifier.volume4en_US
dc.identifier.issue1en_US
dc.identifier.spage36en_US
dc.identifier.epage42en_US
dc.identifier.isiWOS:A1994MN20700006-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridNgan, HYS=34571944100en_US
dc.identifier.scopusauthoridLopes, ADB=55065691900en_US
dc.identifier.scopusauthoridLauder, IJ=35564928000en_US
dc.identifier.scopusauthoridMartin, BH=7402932386en_US
dc.identifier.scopusauthoridWong, LC=7402092003en_US
dc.identifier.scopusauthoridMa, HK=7403095603en_US

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