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Article: The prognostic value of TPA and SCC in squamous cell carcinoma of the cervix

TitleThe prognostic value of TPA and SCC in squamous cell carcinoma of the cervix
Authors
Issue Date1994
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ygyno
Citation
Gynecologic Oncology, 1994, v. 52 n. 1, p. 63-68 How to Cite?
AbstractThree hundred two patients with squamous cell carcinoma of the cervix had pretreatment measurement of serum levels of tissue polypeptide antigen (TPA) and squamous cell carcinoma antigen (SCC) to assess their prognostic value. Both markers were of prognostic significance in relation to stage, recurrence, and poor survival. The addition of TPA to SCC did not increase the percentage of patients with elevated pretreatment tumor marker level nor improve the prognostic significance. One hundred thirty-five of these patients also had serial assay of both markers during follow-up. Rise from normal or persistently elevated markers after treatment was associated with recurrence. The median lead time to recurrence was 2 months for SCC and 2.5 months for TPA. The addition of TPA to SCC in serial monitoring increased the sensitivity of detection of recurrence but decreased its specificity. The cost of assay of two markers over one may not justify the slight improvement in sensitivity of detection of recurrence. For squamous cell carcinoma of the cervix, SCC is a better tumor marker than TPA.
Persistent Identifierhttp://hdl.handle.net/10722/173199
ISSN
2015 Impact Factor: 4.198
2015 SCImago Journal Rankings: 2.284
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorNgan, HYSen_US
dc.contributor.authorCheng, GTSen_US
dc.contributor.authorYeung, WSBen_US
dc.contributor.authorWong, LCen_US
dc.contributor.authorMa, HKen_US
dc.date.accessioned2012-10-30T06:28:28Z-
dc.date.available2012-10-30T06:28:28Z-
dc.date.issued1994en_US
dc.identifier.citationGynecologic Oncology, 1994, v. 52 n. 1, p. 63-68en_US
dc.identifier.issn0090-8258en_US
dc.identifier.urihttp://hdl.handle.net/10722/173199-
dc.description.abstractThree hundred two patients with squamous cell carcinoma of the cervix had pretreatment measurement of serum levels of tissue polypeptide antigen (TPA) and squamous cell carcinoma antigen (SCC) to assess their prognostic value. Both markers were of prognostic significance in relation to stage, recurrence, and poor survival. The addition of TPA to SCC did not increase the percentage of patients with elevated pretreatment tumor marker level nor improve the prognostic significance. One hundred thirty-five of these patients also had serial assay of both markers during follow-up. Rise from normal or persistently elevated markers after treatment was associated with recurrence. The median lead time to recurrence was 2 months for SCC and 2.5 months for TPA. The addition of TPA to SCC in serial monitoring increased the sensitivity of detection of recurrence but decreased its specificity. The cost of assay of two markers over one may not justify the slight improvement in sensitivity of detection of recurrence. For squamous cell carcinoma of the cervix, SCC is a better tumor marker than TPA.en_US
dc.languageengen_US
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ygynoen_US
dc.relation.ispartofGynecologic Oncologyen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 And Overen_US
dc.subject.meshAntigens, Neoplasm - Analysisen_US
dc.subject.meshCarcinoma, Squamous Cell - Mortality - Pathologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshFollow-Up Studiesen_US
dc.subject.meshHumansen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshNeoplasm Recurrence, Localen_US
dc.subject.meshNeoplasm Stagingen_US
dc.subject.meshPeptides - Analysisen_US
dc.subject.meshPrognosisen_US
dc.subject.meshSensitivity And Specificityen_US
dc.subject.meshSerpinsen_US
dc.subject.meshSurvival Rateen_US
dc.subject.meshTissue Polypeptide Antigenen_US
dc.subject.meshTumor Markers, Biological - Analysisen_US
dc.subject.meshUterine Cervical Neoplasms - Mortality - Pathologyen_US
dc.titleThe prognostic value of TPA and SCC in squamous cell carcinoma of the cervixen_US
dc.typeArticleen_US
dc.identifier.emailNgan, HYS:hysngan@hkucc.hku.hken_US
dc.identifier.emailYeung, WSB:wsbyeung@hkucc.hku.hken_US
dc.identifier.authorityNgan, HYS=rp00346en_US
dc.identifier.authorityYeung, WSB=rp00331en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1006/gyno.1994.1012en_US
dc.identifier.pmid8307503-
dc.identifier.scopuseid_2-s2.0-0027976794en_US
dc.identifier.volume52en_US
dc.identifier.issue1en_US
dc.identifier.spage63en_US
dc.identifier.epage68en_US
dc.identifier.isiWOS:A1994MW65600012-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridNgan, HYS=34571944100en_US
dc.identifier.scopusauthoridCheng, GTS=8049877500en_US
dc.identifier.scopusauthoridYeung, WSB=7102370745en_US
dc.identifier.scopusauthoridWong, LC=7402092003en_US
dc.identifier.scopusauthoridMa, HK=7403095603en_US

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