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Article: Serum squamous cell carcinoma antigen in the monitoring of radiotherapy treatment response in carcinoma of the cervix

TitleSerum squamous cell carcinoma antigen in the monitoring of radiotherapy treatment response in carcinoma of the cervix
Authors
Issue Date1990
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ygyno
Citation
Gynecologic Oncology, 1990, v. 37 n. 2, p. 260-263 How to Cite?
AbstractIn this study, squamous cell carcinoma antigen (SCC) was detected in 96 of 157 patients with squamous cell carcinoma of the cervix and the percentage of patients with raised SCC levels increased with the stage of disease (P < 0.01). The use of serial SCC assays and cervical biopsy histology during the course of radiotherapy to predict tumor response to irradiation was assessed. In patients who were given external irradiation before intracavitary radium, a high SCC level or the presence of viable tumor cells in the biopsy was found to be of no predictive value. However, at completion of radiotherapy, i.e., after intracavitary radium application, patients with persistently high SCC levels had a significantly higher incidence of residual tumor than patients whose SCC levels returned to normal (P < 0.01). In 60% of patients with a persistently high SCC level, viable tumor was found in the cervical biopsy at the end of radiotherapy. On the other hand, only 5.4% of patients whose SCC levels returned to normal had residual tumor.
Persistent Identifierhttp://hdl.handle.net/10722/173168
ISSN
2015 Impact Factor: 4.198
2015 SCImago Journal Rankings: 2.284
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorNgan, HYSen_US
dc.contributor.authorChan, SYWen_US
dc.contributor.authorWong, LCen_US
dc.contributor.authorChoy, DTKen_US
dc.contributor.authorMa, HKen_US
dc.date.accessioned2012-10-30T06:28:18Z-
dc.date.available2012-10-30T06:28:18Z-
dc.date.issued1990en_US
dc.identifier.citationGynecologic Oncology, 1990, v. 37 n. 2, p. 260-263en_US
dc.identifier.issn0090-8258en_US
dc.identifier.urihttp://hdl.handle.net/10722/173168-
dc.description.abstractIn this study, squamous cell carcinoma antigen (SCC) was detected in 96 of 157 patients with squamous cell carcinoma of the cervix and the percentage of patients with raised SCC levels increased with the stage of disease (P < 0.01). The use of serial SCC assays and cervical biopsy histology during the course of radiotherapy to predict tumor response to irradiation was assessed. In patients who were given external irradiation before intracavitary radium, a high SCC level or the presence of viable tumor cells in the biopsy was found to be of no predictive value. However, at completion of radiotherapy, i.e., after intracavitary radium application, patients with persistently high SCC levels had a significantly higher incidence of residual tumor than patients whose SCC levels returned to normal (P < 0.01). In 60% of patients with a persistently high SCC level, viable tumor was found in the cervical biopsy at the end of radiotherapy. On the other hand, only 5.4% of patients whose SCC levels returned to normal had residual tumor.en_US
dc.languageengen_US
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ygynoen_US
dc.relation.ispartofGynecologic Oncologyen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAntigens, Neoplasm - Analysisen_US
dc.subject.meshBiopsyen_US
dc.subject.meshCarcinoma, Squamous Cell - Blood - Immunology - Radiotherapyen_US
dc.subject.meshCervix Uteri - Pathologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshRadiation Monitoring - Methodsen_US
dc.subject.meshSerpinsen_US
dc.subject.meshUterine Cervical Neoplasms - Blood - Immunology - Radiotherapyen_US
dc.titleSerum squamous cell carcinoma antigen in the monitoring of radiotherapy treatment response in carcinoma of the cervixen_US
dc.typeArticleen_US
dc.identifier.emailNgan, HYS:hysngan@hkucc.hku.hken_US
dc.identifier.authorityNgan, HYS=rp00346en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0090-8258(90)90344-Ken_US
dc.identifier.pmid2344971-
dc.identifier.scopuseid_2-s2.0-0025335086en_US
dc.identifier.volume37en_US
dc.identifier.issue2en_US
dc.identifier.spage260en_US
dc.identifier.epage263en_US
dc.identifier.isiWOS:A1990DE81300018-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridNgan, HYS=34571944100en_US
dc.identifier.scopusauthoridChan, SYW=7404255960en_US
dc.identifier.scopusauthoridWong, LC=7402092003en_US
dc.identifier.scopusauthoridChoy, DTK=7102939127en_US
dc.identifier.scopusauthoridMa, HK=7403095603en_US

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