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Article: Prognostic implication of proliferative markers MIB-1 and PC10 in esophageal squamous cell carcinoma

TitlePrognostic implication of proliferative markers MIB-1 and PC10 in esophageal squamous cell carcinoma
Authors
Keywordsdifferentiation
Ki- 67
MIB-1
prognosis
proliferating cell nuclear antigen
squamous cell carcinoma
Issue Date1996
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/28741
Citation
Cancer, 1996, v. 77 n. 1, p. 7-13 How to Cite?
AbstractBACKGROUND. Proliferative markers are related to tumor behavior. The commonly used markers are proliferating cell nuclear antigen (PCNA) and Ki- 67. The aim of this study is to evaluate the usefulness of MIB-1 (for Ki-67) and PC10 (for PCNA) in the assessment of the clinicopathologic features and prognosis in patients with esophageal squamous cell carcinoma. METHODS. One hundred patients (88 males, 12 females; mean age, 63 years [range, 39 to 83 years]) with surgically resected esophageal squamous cell carcinoma (32 well differentiated, 51 moderately differentiated, and 17 poorly differentiated) were studied. The clinicopathologic features and survival data of these patients were noted. Representative tissue was collected from each tumor and immunohistochemical preparations for MIB-1 and PC1O were made. RESULTS. The percentages of cells that tested positive for PC10 and MIB-1 were much higher in tumor cells than in nonneoplastic cells. The pattern of expression of both markers varied with the differentiation of the tumor. The results observed with MIB-1 staining were better than those with PC10; because MIB-1 had less background staining, as well as stronger and more uniform positive signals corn pared with PC10. Thus, further investigation was performed on MIB-1- stained sections. The tumor cell MIB-1 scores ranged from 169 to 964 positive cells per 1000 cells (mean 598 ± 211; median, 636). Although it was significantly associated with the differentiation of the tumor (P = 0.0001), the score had no significant relationship to the tumor size, location, or stage, or to the patients' age and sex. The prognosis depended on the size and stage of the lesion. In Stage III lesions (n = 83), patients with MIB-1 scores below 300 had longer actual survival rates than those with a score of 300 or above. However, the survival rates of patients in the latter group were better if the greatest dimension of the tumor diameter was 7.5 cm or less. CONCLUSIONS. Proliferative activity in esophageal squamous cell carcinoma, as defined by the MIB-1 immunohistochemical method, is significantly related to tumor differentiation. It is also potentially valuable as a prognostic marker in addition to its use in tumor staging and size.
Persistent Identifierhttp://hdl.handle.net/10722/172858
ISSN
2015 Impact Factor: 5.649
2015 SCImago Journal Rankings: 3.188
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLam, KYen_HK
dc.contributor.authorLaw, SYKen_HK
dc.contributor.authorSo, MKPen_HK
dc.contributor.authorFok, Men_HK
dc.contributor.authorMa, LTen_HK
dc.contributor.authorWong, Jen_HK
dc.date.accessioned2012-10-30T06:25:22Z-
dc.date.available2012-10-30T06:25:22Z-
dc.date.issued1996en_HK
dc.identifier.citationCancer, 1996, v. 77 n. 1, p. 7-13en_HK
dc.identifier.issn0008-543Xen_HK
dc.identifier.urihttp://hdl.handle.net/10722/172858-
dc.description.abstractBACKGROUND. Proliferative markers are related to tumor behavior. The commonly used markers are proliferating cell nuclear antigen (PCNA) and Ki- 67. The aim of this study is to evaluate the usefulness of MIB-1 (for Ki-67) and PC10 (for PCNA) in the assessment of the clinicopathologic features and prognosis in patients with esophageal squamous cell carcinoma. METHODS. One hundred patients (88 males, 12 females; mean age, 63 years [range, 39 to 83 years]) with surgically resected esophageal squamous cell carcinoma (32 well differentiated, 51 moderately differentiated, and 17 poorly differentiated) were studied. The clinicopathologic features and survival data of these patients were noted. Representative tissue was collected from each tumor and immunohistochemical preparations for MIB-1 and PC1O were made. RESULTS. The percentages of cells that tested positive for PC10 and MIB-1 were much higher in tumor cells than in nonneoplastic cells. The pattern of expression of both markers varied with the differentiation of the tumor. The results observed with MIB-1 staining were better than those with PC10; because MIB-1 had less background staining, as well as stronger and more uniform positive signals corn pared with PC10. Thus, further investigation was performed on MIB-1- stained sections. The tumor cell MIB-1 scores ranged from 169 to 964 positive cells per 1000 cells (mean 598 ± 211; median, 636). Although it was significantly associated with the differentiation of the tumor (P = 0.0001), the score had no significant relationship to the tumor size, location, or stage, or to the patients' age and sex. The prognosis depended on the size and stage of the lesion. In Stage III lesions (n = 83), patients with MIB-1 scores below 300 had longer actual survival rates than those with a score of 300 or above. However, the survival rates of patients in the latter group were better if the greatest dimension of the tumor diameter was 7.5 cm or less. CONCLUSIONS. Proliferative activity in esophageal squamous cell carcinoma, as defined by the MIB-1 immunohistochemical method, is significantly related to tumor differentiation. It is also potentially valuable as a prognostic marker in addition to its use in tumor staging and size.en_HK
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/28741en_HK
dc.relation.ispartofCanceren_HK
dc.subjectdifferentiationen_HK
dc.subjectKi- 67en_HK
dc.subjectMIB-1en_HK
dc.subjectprognosisen_HK
dc.subjectproliferating cell nuclear antigenen_HK
dc.subjectsquamous cell carcinomaen_HK
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 And Overen_US
dc.subject.meshAntigens, Nuclearen_US
dc.subject.meshCarcinoma, Squamous Cell - Mortality - Pathologyen_US
dc.subject.meshEsophageal Neoplasms - Mortality - Pathologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshKi-67 Antigenen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshNuclear Proteins - Isolation & Purificationen_US
dc.subject.meshPrognosisen_US
dc.subject.meshProliferating Cell Nuclear Antigen - Isolation & Purificationen_US
dc.subject.meshSurvival Rateen_US
dc.subject.meshTumor Markers, Biological - Isolation & Purificationen_US
dc.titlePrognostic implication of proliferative markers MIB-1 and PC10 in esophageal squamous cell carcinomaen_HK
dc.typeArticleen_HK
dc.identifier.emailLaw, SYK: slaw@hku.hken_HK
dc.identifier.emailWong, J: jwong@hkucc.hku.hken_HK
dc.identifier.authorityLaw, SYK=rp00437en_HK
dc.identifier.authorityWong, J=rp00322en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/(SICI)1097-0142(19960101)77:1<7::AID-CNCR3>3.0.CO;2-Nen_HK
dc.identifier.pmid8630942en_HK
dc.identifier.scopuseid_2-s2.0-13344281014en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-13344281014&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume77en_HK
dc.identifier.issue1en_HK
dc.identifier.spage7en_HK
dc.identifier.epage13en_HK
dc.identifier.isiWOS:A1996TL67000003-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLam, KY=7403657165en_HK
dc.identifier.scopusauthoridLaw, SYK=7202241293en_HK
dc.identifier.scopusauthoridSo, MKP=36719004700en_HK
dc.identifier.scopusauthoridFok, M=7005879262en_HK
dc.identifier.scopusauthoridMa, LT=7403574642en_HK
dc.identifier.scopusauthoridWong, J=8049324500en_HK

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