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Article: A three-year prospective study of spontaneous eye-blink rate in first-episode schizophrenia: Relationship with relapse and neurocognitive function

TitleA three-year prospective study of spontaneous eye-blink rate in first-episode schizophrenia: Relationship with relapse and neurocognitive function
Authors
KeywordsBlinking
Cognition
Dopamine
Recurrence
Schizophrenia
Issue Date2010
PublisherHong Kong Academy of Medicine Press. The Journal's web site is located at http://www.hkjpsych.com/search.jsp
Citation
East Asian Archives Of Psychiatry, 2010, v. 20 n. 4, p. 174-179 How to Cite?
AbstractObjective: To examine the spontaneous blink rate over a 3-year period and its clinical and cognitive correlates among patients with first-episode schizophrenia. Methods: This study prospectively followed 93 patients with first-episode schizophrenia, schizophreniform and schizoaffective disorders for 3 years. Patients were longitudinally assessed for blink rate, their positive and negative symptoms, and a range of cognitive features including verbal fluency, verbal memory, visual memory, and the Wisconsin Card Sorting Test performance. Results: When compared with a matched control group, there was a significantly higher blink rate at their 3-year follow-up but not at initial presentation. The increase in blink rate over time correlated positively with the number of relapses. It also correlated with logical memory, verbal fluency, categories completed, and perseverative errors in the Wisconsin Card Sorting Test. The increased blink rate also correlated with pre-morbid schizoid and schizotypal traits. All these correlations were statistically significant. Conclusion: The change in the blink rate over time may reflect underlying involvement of the dopaminergic system in mediating relapse and cognitive functions. © 2010 Hong Kong College of Psychiatrists.
Persistent Identifierhttp://hdl.handle.net/10722/171960
ISSN
2015 SCImago Journal Rankings: 0.331
References

 

DC FieldValueLanguage
dc.contributor.authorChan, KKSen_HK
dc.contributor.authorHui, CLMen_HK
dc.contributor.authorLam, MMLen_HK
dc.contributor.authorTang, JYMen_HK
dc.contributor.authorWong, GHYen_HK
dc.contributor.authorChan, SKWen_HK
dc.contributor.authorChen, EYHen_HK
dc.date.accessioned2012-10-30T06:18:50Z-
dc.date.available2012-10-30T06:18:50Z-
dc.date.issued2010en_HK
dc.identifier.citationEast Asian Archives Of Psychiatry, 2010, v. 20 n. 4, p. 174-179en_HK
dc.identifier.issn2078-9947en_HK
dc.identifier.urihttp://hdl.handle.net/10722/171960-
dc.description.abstractObjective: To examine the spontaneous blink rate over a 3-year period and its clinical and cognitive correlates among patients with first-episode schizophrenia. Methods: This study prospectively followed 93 patients with first-episode schizophrenia, schizophreniform and schizoaffective disorders for 3 years. Patients were longitudinally assessed for blink rate, their positive and negative symptoms, and a range of cognitive features including verbal fluency, verbal memory, visual memory, and the Wisconsin Card Sorting Test performance. Results: When compared with a matched control group, there was a significantly higher blink rate at their 3-year follow-up but not at initial presentation. The increase in blink rate over time correlated positively with the number of relapses. It also correlated with logical memory, verbal fluency, categories completed, and perseverative errors in the Wisconsin Card Sorting Test. The increased blink rate also correlated with pre-morbid schizoid and schizotypal traits. All these correlations were statistically significant. Conclusion: The change in the blink rate over time may reflect underlying involvement of the dopaminergic system in mediating relapse and cognitive functions. © 2010 Hong Kong College of Psychiatrists.en_HK
dc.languageengen_US
dc.publisherHong Kong Academy of Medicine Press. The Journal's web site is located at http://www.hkjpsych.com/search.jspen_HK
dc.relation.ispartofEast Asian Archives of Psychiatryen_HK
dc.subjectBlinkingen_HK
dc.subjectCognitionen_HK
dc.subjectDopamineen_HK
dc.subjectRecurrenceen_HK
dc.subjectSchizophreniaen_HK
dc.titleA three-year prospective study of spontaneous eye-blink rate in first-episode schizophrenia: Relationship with relapse and neurocognitive functionen_HK
dc.typeArticleen_HK
dc.identifier.emailLam, MML: maylam11@hku.hken_HK
dc.identifier.emailChan, SKW: kwsherry@hku.hken_HK
dc.identifier.emailChen, EYH: eyhchen@hku.hken_HK
dc.identifier.authorityLam, MML=rp00296en_HK
dc.identifier.authorityChan, SKW=rp00539en_HK
dc.identifier.authorityChen, EYH=rp00392en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.scopuseid_2-s2.0-78651325864en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-78651325864&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume20en_HK
dc.identifier.issue4en_HK
dc.identifier.spage174en_HK
dc.identifier.epage179en_HK
dc.publisher.placeHong Kongen_HK
dc.identifier.scopusauthoridChan, KKS=36448818400en_HK
dc.identifier.scopusauthoridHui, CLM=35734149500en_HK
dc.identifier.scopusauthoridLam, MML=13106178700en_HK
dc.identifier.scopusauthoridTang, JYM=35086815700en_HK
dc.identifier.scopusauthoridWong, GHY=24465754400en_HK
dc.identifier.scopusauthoridChan, SKW=26424509100en_HK
dc.identifier.scopusauthoridChen, EYH=7402315729en_HK

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