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Article: Left ventricular torsional mechanics and diastolic function in congenital heart block with right ventricular pacing
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TitleLeft ventricular torsional mechanics and diastolic function in congenital heart block with right ventricular pacing
 
AuthorsKoh, C1
Hong, WJ1
Yung, TC1
Lun, KS1
Wong, SJ1
Cheung, YF1
 
KeywordsCardiovascular parameters
Congenital heart block
Diastolic untwisting velocity
Doppler echocardiography
Echocardiography
 
Issue Date2012
 
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ijcard
 
CitationInternational Journal of Cardiology, 2012, v. 160 n. 1, p. 31-35 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.ijcard.2011.03.018
 
AbstractBACKGROUND: The effects of right ventricular (RV) pacing on left ventricular (LV) diastolic function are unknown. This study aimed to test the hypothesis that right ventricular (RV) pacing is associated with LV diastolic dysfunction and impairment of LV torsion in children and young adults with congenital heart block. METHODS: Eighteen patients aged 20 +/- 7 years and 12 healthy controls aged 19 +/- 7 years were studied. Transmitral and mitral annular diastolic velocities and global longitudinal diastolic strain rate were determined and compared between the 2 groups. Parameters of LV torsion including peak systolic basal and apical rotations, and systolic twisting and diastolic untwisting velocities were further determined by speckle tracking echocardiography. In 12 patients, these parameters were compared before and after interruption of RV pacing. RESULTS: Compared with controls, patients had significantly lower mitral early diastolic annular velocity (p=0.007), LV global diastolic strain rate (p<0.001), basal (p<0.001) and apical (p=0.002) rotations, peak systolic torsion (p<0.001), and peak systolic twisting velocities (p=0.009). In patients, the peak diastolic untwisting velocity correlated with peak systolic torsion (r=0.64, p=0.004) and peak systolic twisting velocity (r=0.74, p<0.001). No significant improvement in LV diastolic function or torsion was observed during pacing interruption (all p>0.05). CONCLUSION: Right ventricular pacing in childhood is associated with LV diastolic dysfunction and impaired LV torsion, which do not improve with pacing interruption.
 
ISSN0167-5273
2013 Impact Factor: 6.175
2013 SCImago Journal Rankings: 0.930
 
DOIhttp://dx.doi.org/10.1016/j.ijcard.2011.03.018
 
DC FieldValue
dc.contributor.authorKoh, C
 
dc.contributor.authorHong, WJ
 
dc.contributor.authorYung, TC
 
dc.contributor.authorLun, KS
 
dc.contributor.authorWong, SJ
 
dc.contributor.authorCheung, YF
 
dc.date.accessioned2012-10-30T06:09:01Z
 
dc.date.available2012-10-30T06:09:01Z
 
dc.date.issued2012
 
dc.description.abstractBACKGROUND: The effects of right ventricular (RV) pacing on left ventricular (LV) diastolic function are unknown. This study aimed to test the hypothesis that right ventricular (RV) pacing is associated with LV diastolic dysfunction and impairment of LV torsion in children and young adults with congenital heart block. METHODS: Eighteen patients aged 20 +/- 7 years and 12 healthy controls aged 19 +/- 7 years were studied. Transmitral and mitral annular diastolic velocities and global longitudinal diastolic strain rate were determined and compared between the 2 groups. Parameters of LV torsion including peak systolic basal and apical rotations, and systolic twisting and diastolic untwisting velocities were further determined by speckle tracking echocardiography. In 12 patients, these parameters were compared before and after interruption of RV pacing. RESULTS: Compared with controls, patients had significantly lower mitral early diastolic annular velocity (p=0.007), LV global diastolic strain rate (p<0.001), basal (p<0.001) and apical (p=0.002) rotations, peak systolic torsion (p<0.001), and peak systolic twisting velocities (p=0.009). In patients, the peak diastolic untwisting velocity correlated with peak systolic torsion (r=0.64, p=0.004) and peak systolic twisting velocity (r=0.74, p<0.001). No significant improvement in LV diastolic function or torsion was observed during pacing interruption (all p>0.05). CONCLUSION: Right ventricular pacing in childhood is associated with LV diastolic dysfunction and impaired LV torsion, which do not improve with pacing interruption.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationInternational Journal of Cardiology, 2012, v. 160 n. 1, p. 31-35 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.ijcard.2011.03.018
 
dc.identifier.citeulike9129565
 
dc.identifier.doihttp://dx.doi.org/10.1016/j.ijcard.2011.03.018
 
dc.identifier.epage35
 
dc.identifier.hkuros208644
 
dc.identifier.issn0167-5273
2013 Impact Factor: 6.175
2013 SCImago Journal Rankings: 0.930
 
dc.identifier.issue1
 
dc.identifier.pmid21481959
 
dc.identifier.scopuseid_2-s2.0-84865631800
 
dc.identifier.spage31
 
dc.identifier.urihttp://hdl.handle.net/10722/170449
 
dc.identifier.volume160
 
dc.languageeng
 
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ijcard
 
dc.publisher.placeIreland
 
dc.relation.ispartofInternational Journal of Cardiology
 
dc.subjectCardiovascular parameters
 
dc.subjectCongenital heart block
 
dc.subjectDiastolic untwisting velocity
 
dc.subjectDoppler echocardiography
 
dc.subjectEchocardiography
 
dc.titleLeft ventricular torsional mechanics and diastolic function in congenital heart block with right ventricular pacing
 
dc.typeArticle
 
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<item><contributor.author>Koh, C</contributor.author>
<contributor.author>Hong, WJ</contributor.author>
<contributor.author>Yung, TC</contributor.author>
<contributor.author>Lun, KS</contributor.author>
<contributor.author>Wong, SJ</contributor.author>
<contributor.author>Cheung, YF</contributor.author>
<date.accessioned>2012-10-30T06:09:01Z</date.accessioned>
<date.available>2012-10-30T06:09:01Z</date.available>
<date.issued>2012</date.issued>
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<description.abstract>BACKGROUND: The effects of right ventricular (RV) pacing on left ventricular (LV) diastolic function are unknown. This study aimed to test the hypothesis that right ventricular (RV) pacing is associated with LV diastolic dysfunction and impairment of LV torsion in children and young adults with congenital heart block. METHODS: Eighteen patients aged 20 +/- 7 years and 12 healthy controls aged 19 +/- 7 years were studied. Transmitral and mitral annular diastolic velocities and global longitudinal diastolic strain rate were determined and compared between the 2 groups. Parameters of LV torsion including peak systolic basal and apical rotations, and systolic twisting and diastolic untwisting velocities were further determined by speckle tracking echocardiography. In 12 patients, these parameters were compared before and after interruption of RV pacing. RESULTS: Compared with controls, patients had significantly lower mitral early diastolic annular velocity (p=0.007), LV global diastolic strain rate (p&lt;0.001), basal (p&lt;0.001) and apical (p=0.002) rotations, peak systolic torsion (p&lt;0.001), and peak systolic twisting velocities (p=0.009). In patients, the peak diastolic untwisting velocity correlated with peak systolic torsion (r=0.64, p=0.004) and peak systolic twisting velocity (r=0.74, p&lt;0.001). No significant improvement in LV diastolic function or torsion was observed during pacing interruption (all p&gt;0.05). CONCLUSION: Right ventricular pacing in childhood is associated with LV diastolic dysfunction and impaired LV torsion, which do not improve with pacing interruption.</description.abstract>
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Author Affiliations
  1. The University of Hong Kong