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Article: Left ventricular torsional mechanics and diastolic function in congenital heart block with right ventricular pacing

TitleLeft ventricular torsional mechanics and diastolic function in congenital heart block with right ventricular pacing
Authors
KeywordsCardiovascular parameters
Congenital heart block
Diastolic untwisting velocity
Doppler echocardiography
Echocardiography
Issue Date2012
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ijcard
Citation
International Journal of Cardiology, 2012, v. 160 n. 1, p. 31-35 How to Cite?
Abstract
BACKGROUND: The effects of right ventricular (RV) pacing on left ventricular (LV) diastolic function are unknown. This study aimed to test the hypothesis that right ventricular (RV) pacing is associated with LV diastolic dysfunction and impairment of LV torsion in children and young adults with congenital heart block. METHODS: Eighteen patients aged 20 +/- 7 years and 12 healthy controls aged 19 +/- 7 years were studied. Transmitral and mitral annular diastolic velocities and global longitudinal diastolic strain rate were determined and compared between the 2 groups. Parameters of LV torsion including peak systolic basal and apical rotations, and systolic twisting and diastolic untwisting velocities were further determined by speckle tracking echocardiography. In 12 patients, these parameters were compared before and after interruption of RV pacing. RESULTS: Compared with controls, patients had significantly lower mitral early diastolic annular velocity (p=0.007), LV global diastolic strain rate (p<0.001), basal (p<0.001) and apical (p=0.002) rotations, peak systolic torsion (p<0.001), and peak systolic twisting velocities (p=0.009). In patients, the peak diastolic untwisting velocity correlated with peak systolic torsion (r=0.64, p=0.004) and peak systolic twisting velocity (r=0.74, p<0.001). No significant improvement in LV diastolic function or torsion was observed during pacing interruption (all p>0.05). CONCLUSION: Right ventricular pacing in childhood is associated with LV diastolic dysfunction and impaired LV torsion, which do not improve with pacing interruption.
Persistent Identifierhttp://hdl.handle.net/10722/170449
ISSN
2013 Impact Factor: 6.175
2013 SCImago Journal Rankings: 0.930
ISI Accession Number ID

 

Author Affiliations
  1. The University of Hong Kong
DC FieldValueLanguage
dc.contributor.authorKoh, Cen_US
dc.contributor.authorHong, WJen_US
dc.contributor.authorYung, TCen_US
dc.contributor.authorLun, KSen_US
dc.contributor.authorWong, SJen_US
dc.contributor.authorCheung, YFen_US
dc.date.accessioned2012-10-30T06:09:01Z-
dc.date.available2012-10-30T06:09:01Z-
dc.date.issued2012en_US
dc.identifier.citationInternational Journal of Cardiology, 2012, v. 160 n. 1, p. 31-35en_US
dc.identifier.issn0167-5273en_US
dc.identifier.urihttp://hdl.handle.net/10722/170449-
dc.description.abstractBACKGROUND: The effects of right ventricular (RV) pacing on left ventricular (LV) diastolic function are unknown. This study aimed to test the hypothesis that right ventricular (RV) pacing is associated with LV diastolic dysfunction and impairment of LV torsion in children and young adults with congenital heart block. METHODS: Eighteen patients aged 20 +/- 7 years and 12 healthy controls aged 19 +/- 7 years were studied. Transmitral and mitral annular diastolic velocities and global longitudinal diastolic strain rate were determined and compared between the 2 groups. Parameters of LV torsion including peak systolic basal and apical rotations, and systolic twisting and diastolic untwisting velocities were further determined by speckle tracking echocardiography. In 12 patients, these parameters were compared before and after interruption of RV pacing. RESULTS: Compared with controls, patients had significantly lower mitral early diastolic annular velocity (p=0.007), LV global diastolic strain rate (p<0.001), basal (p<0.001) and apical (p=0.002) rotations, peak systolic torsion (p<0.001), and peak systolic twisting velocities (p=0.009). In patients, the peak diastolic untwisting velocity correlated with peak systolic torsion (r=0.64, p=0.004) and peak systolic twisting velocity (r=0.74, p<0.001). No significant improvement in LV diastolic function or torsion was observed during pacing interruption (all p>0.05). CONCLUSION: Right ventricular pacing in childhood is associated with LV diastolic dysfunction and impaired LV torsion, which do not improve with pacing interruption.en_US
dc.languageengen_US
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ijcarden_US
dc.relation.ispartofInternational Journal of Cardiologyen_US
dc.subjectCardiovascular parametersen_US
dc.subjectCongenital heart blocken_US
dc.subjectDiastolic untwisting velocityen_US
dc.subjectDoppler echocardiographyen_US
dc.subjectEchocardiography-
dc.titleLeft ventricular torsional mechanics and diastolic function in congenital heart block with right ventricular pacingen_US
dc.typeArticleen_US
dc.identifier.emailYung, TC: tcyung@hkusua.hku.hken_US
dc.identifier.emailLun, KS: lunks@hkucc.hku.hk-
dc.identifier.emailWong, SJ: sjwong@hku.hk-
dc.identifier.emailCheung, YF: xfcheung@hku.hk-
dc.identifier.authorityCheung, YF=rp00382en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.ijcard.2011.03.018en_US
dc.identifier.pmid21481959-
dc.identifier.scopuseid_2-s2.0-84865631800en_US
dc.identifier.hkuros208644-
dc.identifier.volume160-
dc.identifier.issue1-
dc.identifier.spage31-
dc.identifier.epage35-
dc.identifier.isiWOS:000308463900013-
dc.publisher.placeIrelanden_US
dc.identifier.scopusauthoridCheung, YF=7202111067en_US
dc.identifier.scopusauthoridWong, SJ=25924109100en_US
dc.identifier.scopusauthoridLun, KS=8363663600en_US
dc.identifier.scopusauthoridYung, TC=9132842300en_US
dc.identifier.scopusauthoridHong, WJ=14010481700en_US
dc.identifier.scopusauthoridKoh, C=26321638500en_US
dc.identifier.citeulike9129565-

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