Article: Left ventricular torsional mechanics and diastolic function in congenital heart block with right ventricular pacing

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TitleLeft ventricular torsional mechanics and diastolic function in congenital heart block with right ventricular pacing
AuthorsKoh, C1
Hong, WJ1
Yung, TC1
Lun, KS1
Wong, SJ1
Cheung, YF1
KeywordsCardiovascular parameters
Congenital heart block
Diastolic untwisting velocity
Doppler echocardiography
Echocardiography
Issue Date2012
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ijcard
CitationInternational Journal of Cardiology, 2012, v. 160 n. 1, p. 31-35 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.ijcard.2011.03.018
AbstractBACKGROUND: The effects of right ventricular (RV) pacing on left ventricular (LV) diastolic function are unknown. This study aimed to test the hypothesis that right ventricular (RV) pacing is associated with LV diastolic dysfunction and impairment of LV torsion in children and young adults with congenital heart block. METHODS: Eighteen patients aged 20 +/- 7 years and 12 healthy controls aged 19 +/- 7 years were studied. Transmitral and mitral annular diastolic velocities and global longitudinal diastolic strain rate were determined and compared between the 2 groups. Parameters of LV torsion including peak systolic basal and apical rotations, and systolic twisting and diastolic untwisting velocities were further determined by speckle tracking echocardiography. In 12 patients, these parameters were compared before and after interruption of RV pacing. RESULTS: Compared with controls, patients had significantly lower mitral early diastolic annular velocity (p=0.007), LV global diastolic strain rate (p<0.001), basal (p<0.001) and apical (p=0.002) rotations, peak systolic torsion (p<0.001), and peak systolic twisting velocities (p=0.009). In patients, the peak diastolic untwisting velocity correlated with peak systolic torsion (r=0.64, p=0.004) and peak systolic twisting velocity (r=0.74, p<0.001). No significant improvement in LV diastolic function or torsion was observed during pacing interruption (all p>0.05). CONCLUSION: Right ventricular pacing in childhood is associated with LV diastolic dysfunction and impaired LV torsion, which do not improve with pacing interruption.
ISSN0167-5273
2011 Impact Factor: 7.078
2011 SCImago Journal Rankings: 0.144
DOIhttp://dx.doi.org/10.1016/j.ijcard.2011.03.018
DC Field
Value
dc.contributor.authorKoh, C
dc.contributor.authorHong, WJ
dc.contributor.authorYung, TC
dc.contributor.authorLun, KS
dc.contributor.authorWong, SJ
dc.contributor.authorCheung, YF
dc.date.accessioned2012-10-30T06:09:01Z
dc.date.available2012-10-30T06:09:01Z
dc.date.issued2012
dc.description.abstractBACKGROUND: The effects of right ventricular (RV) pacing on left ventricular (LV) diastolic function are unknown. This study aimed to test the hypothesis that right ventricular (RV) pacing is associated with LV diastolic dysfunction and impairment of LV torsion in children and young adults with congenital heart block. METHODS: Eighteen patients aged 20 +/- 7 years and 12 healthy controls aged 19 +/- 7 years were studied. Transmitral and mitral annular diastolic velocities and global longitudinal diastolic strain rate were determined and compared between the 2 groups. Parameters of LV torsion including peak systolic basal and apical rotations, and systolic twisting and diastolic untwisting velocities were further determined by speckle tracking echocardiography. In 12 patients, these parameters were compared before and after interruption of RV pacing. RESULTS: Compared with controls, patients had significantly lower mitral early diastolic annular velocity (p=0.007), LV global diastolic strain rate (p<0.001), basal (p<0.001) and apical (p=0.002) rotations, peak systolic torsion (p<0.001), and peak systolic twisting velocities (p=0.009). In patients, the peak diastolic untwisting velocity correlated with peak systolic torsion (r=0.64, p=0.004) and peak systolic twisting velocity (r=0.74, p<0.001). No significant improvement in LV diastolic function or torsion was observed during pacing interruption (all p>0.05). CONCLUSION: Right ventricular pacing in childhood is associated with LV diastolic dysfunction and impaired LV torsion, which do not improve with pacing interruption.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationInternational Journal of Cardiology, 2012, v. 160 n. 1, p. 31-35 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.ijcard.2011.03.018
dc.identifier.citeulike9129565
dc.identifier.doihttp://dx.doi.org/10.1016/j.ijcard.2011.03.018
dc.identifier.epage35
dc.identifier.hkuros208644
dc.identifier.issn0167-5273
2011 Impact Factor: 7.078
2011 SCImago Journal Rankings: 0.144
dc.identifier.issue1
dc.identifier.pmid21481959
dc.identifier.scopuseid_2-s2.0-84865631800
dc.identifier.spage31
dc.identifier.urihttp://hdl.handle.net/10722/170449
dc.identifier.volume160
dc.languageeng
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ijcard
dc.publisher.placeIreland
dc.relation.ispartofInternational Journal of Cardiology
dc.subjectCardiovascular parameters
dc.subjectCongenital heart block
dc.subjectDiastolic untwisting velocity
dc.subjectDoppler echocardiography
dc.subjectEchocardiography
dc.titleLeft ventricular torsional mechanics and diastolic function in congenital heart block with right ventricular pacing
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong