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Article: Brain natriuretic peptide as a biomarker of systemic right ventricular function in patients with transposition of great arteries after atrial switch operation

TitleBrain natriuretic peptide as a biomarker of systemic right ventricular function in patients with transposition of great arteries after atrial switch operation
Authors
Issue Date2008
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ijcard
Citation
International Journal Of Cardiology, 2008, v. 127 n. 2, p. 192-197 How to Cite?
AbstractBackground: Assessment of systemic right ventricular (RV) function is inherently difficult. In adults, plasma brain natriuretic peptide (BNP) level has been shown to reflect systemic ventricular dysfunction. We sought to test the hypothesis that plasma BNP is a biomarker of systemic RV function in patients after atrial switch operation. Methods: We determined the RV function in 44 patients, 35 after Senning and 9 after Mustard operation, aged 19.7 ± 4.0 years, by tissue Doppler echocardiography and determination of myocardial performance index (MPI). The results were compared to the left ventricular function of 14 age-matched controls. Their plasma BNP levels were correlated with indices of systemic ventricular function. Results: Compared with controls, the patients had greater MPI (p < 0.001), lower systemic ventricular free wall-annular early diastolic (p < 0.001), late diastolic (p < 0.001), and systolic velocities (p = 0.001), lower septal-annular early diastolic (p < 0.001), late diastolic (p < 0.001), and systolic velocities (p < 0.001), and higher BNP levels (p = 0.03). Plasma BNP levels correlated positively with MPI (r = 0.43, p = 0.001) and negatively with the free wall- and septal-annular myocardial velocities (r = - 0.32 to - 0.47, p < 0.05). The area under the receiver operating characteristic curve for BNP to detect ventricular dysfunction (MPI > 0.45) in patients was 0.67 (p = 0.04). A BNP level of 36 pg/ml had a sensitivity of 55%, specificity of 86%, positive predictive value 80%, negative predictive value of 64%, and an accuracy of 70% for detecting systemic ventricular dysfunction. Conclusions: Plasma BNP has modest accuracy in the detection of systemic RV dysfunction in patients after atrial switch operation. © 2007 Elsevier Ireland Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/170398
ISSN
2015 Impact Factor: 4.638
2015 SCImago Journal Rankings: 1.513
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChow, Pcen_US
dc.contributor.authorCheung, EWyen_US
dc.contributor.authorChong, Cyen_US
dc.contributor.authorLun, Ksen_US
dc.contributor.authorYung, Tcen_US
dc.contributor.authorWong, Kten_US
dc.contributor.authorChau, AKten_US
dc.contributor.authorCheung, Yfen_US
dc.date.accessioned2012-10-30T06:08:01Z-
dc.date.available2012-10-30T06:08:01Z-
dc.date.issued2008en_US
dc.identifier.citationInternational Journal Of Cardiology, 2008, v. 127 n. 2, p. 192-197en_US
dc.identifier.issn0167-5273en_US
dc.identifier.urihttp://hdl.handle.net/10722/170398-
dc.description.abstractBackground: Assessment of systemic right ventricular (RV) function is inherently difficult. In adults, plasma brain natriuretic peptide (BNP) level has been shown to reflect systemic ventricular dysfunction. We sought to test the hypothesis that plasma BNP is a biomarker of systemic RV function in patients after atrial switch operation. Methods: We determined the RV function in 44 patients, 35 after Senning and 9 after Mustard operation, aged 19.7 ± 4.0 years, by tissue Doppler echocardiography and determination of myocardial performance index (MPI). The results were compared to the left ventricular function of 14 age-matched controls. Their plasma BNP levels were correlated with indices of systemic ventricular function. Results: Compared with controls, the patients had greater MPI (p < 0.001), lower systemic ventricular free wall-annular early diastolic (p < 0.001), late diastolic (p < 0.001), and systolic velocities (p = 0.001), lower septal-annular early diastolic (p < 0.001), late diastolic (p < 0.001), and systolic velocities (p < 0.001), and higher BNP levels (p = 0.03). Plasma BNP levels correlated positively with MPI (r = 0.43, p = 0.001) and negatively with the free wall- and septal-annular myocardial velocities (r = - 0.32 to - 0.47, p < 0.05). The area under the receiver operating characteristic curve for BNP to detect ventricular dysfunction (MPI > 0.45) in patients was 0.67 (p = 0.04). A BNP level of 36 pg/ml had a sensitivity of 55%, specificity of 86%, positive predictive value 80%, negative predictive value of 64%, and an accuracy of 70% for detecting systemic ventricular dysfunction. Conclusions: Plasma BNP has modest accuracy in the detection of systemic RV dysfunction in patients after atrial switch operation. © 2007 Elsevier Ireland Ltd. All rights reserved.en_US
dc.languageengen_US
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ijcarden_US
dc.relation.ispartofInternational Journal of Cardiologyen_US
dc.subject.meshAdulten_US
dc.subject.meshBiological Markers - Blooden_US
dc.subject.meshCardiac Surgical Proceduresen_US
dc.subject.meshCase-Control Studiesen_US
dc.subject.meshDiastoleen_US
dc.subject.meshEchocardiography, Doppleren_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshNatriuretic Peptide, Brain - Blooden_US
dc.subject.meshRoc Curveen_US
dc.subject.meshSensitivity And Specificityen_US
dc.subject.meshStatistics, Nonparametricen_US
dc.subject.meshSystoleen_US
dc.subject.meshTransposition Of Great Vessels - Blood - Surgery - Ultrasonographyen_US
dc.subject.meshVentricular Dysfunction, Right - Blooden_US
dc.titleBrain natriuretic peptide as a biomarker of systemic right ventricular function in patients with transposition of great arteries after atrial switch operationen_US
dc.typeArticleen_US
dc.identifier.emailCheung, Yf:xfcheung@hku.hken_US
dc.identifier.authorityCheung, Yf=rp00382en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.ijcard.2007.06.004en_US
dc.identifier.pmid17643533-
dc.identifier.scopuseid_2-s2.0-44649094448en_US
dc.identifier.hkuros145889-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-44649094448&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume127en_US
dc.identifier.issue2en_US
dc.identifier.spage192en_US
dc.identifier.epage197en_US
dc.identifier.isiWOS:000256661000008-
dc.publisher.placeIrelanden_US
dc.identifier.scopusauthoridChow, Pc=23099233800en_US
dc.identifier.scopusauthoridCheung, EWy=9432819700en_US
dc.identifier.scopusauthoridChong, Cy=24337398200en_US
dc.identifier.scopusauthoridLun, Ks=8363663600en_US
dc.identifier.scopusauthoridYung, Tc=9132842300en_US
dc.identifier.scopusauthoridWong, Kt=9039171300en_US
dc.identifier.scopusauthoridChau, AKt=35787094400en_US
dc.identifier.scopusauthoridCheung, Yf=7202111067en_US
dc.identifier.citeulike10077868-

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