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Article: Plasma brain natriuretic peptide levels, right ventricular volume overload and exercise capacity in adolescents after surgical repair of tetralogy of Fallot
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TitlePlasma brain natriuretic peptide levels, right ventricular volume overload and exercise capacity in adolescents after surgical repair of tetralogy of Fallot
 
AuthorsCheung, EWY1
Lam, WWM2
Chiu, CSW2
Chau, AKT1
Cheung, SCW2
Cheung, Yf1
 
Issue Date2007
 
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ijcard
 
CitationInternational Journal Of Cardiology, 2007, v. 121 n. 2, p. 155-162 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.ijcard.2006.10.024
 
AbstractBackground: Right ventricular (RV) volume overload secondary to pulmonary regurgitation contributes to long-term morbidities in patients after tetralogy of Fallot (TOF) repair. We tested the hypothesis that plasma brain natriuretic peptide (BNP) levels relate to RV volume overload, pulmonary regurgitation, and exercise capacity in adolescents after TOF repair. Methods: We assessed the RV function echocardiographically and plasma BNP levels in 32 postoperative TOF patients aged 14.7 ± 3.1 years and 20 age-matched controls. Eighteen patients further underwent cardiovascular magnetic resonance imaging and 26 had exercise testing. Results: Compared with controls, patients had significantly higher BNP levels (p = 0.027), greater indexed RV end-diastolic dimension (p < 0.001), increased RV myocardial performance index (p = 0.005), and reduced tricuspid annular systolic velocity (p = 0.008). Multivariate analysis identified indexed RV end-diastolic dimension as the only significant determinant of plasma BNP levels (β = 0.69, p < 0.001). Plasma BNP levels correlated positively with indexed RV end-diastolic volume (r = 0.6, p = 0.009) and pulmonary regurgitant fraction (r = 0.54, p = 0.026), and negatively with exercise duration (r = - 0.45, p = 0.021), peak oxygen consumption (r = - 0.43, p = 0.03), and minute ventilation at maximal exercise (r = - 0.52, p = 0.006). Multivariate analysis demonstrated BNP levels (β = - 0.43, p = 0.034) and body mass index (β = - 0.40, p = 0.036) to be independent predictors of peak oxygen consumption. No relations were found between BNP levels and RV myocardial performance index, tricuspid annular velocities and RV ejection fraction. Conclusions: In adolescent patients after TOF repair, plasma BNP levels relate to RV volume overload, pulmonary regurgitation and exercise capacity. © 2006 Elsevier Ireland Ltd. All rights reserved.
 
ISSN0167-5273
2012 Impact Factor: 5.509
2012 SCImago Journal Rankings: 0.788
 
DOIhttp://dx.doi.org/10.1016/j.ijcard.2006.10.024
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorCheung, EWY
 
dc.contributor.authorLam, WWM
 
dc.contributor.authorChiu, CSW
 
dc.contributor.authorChau, AKT
 
dc.contributor.authorCheung, SCW
 
dc.contributor.authorCheung, Yf
 
dc.date.accessioned2012-10-30T06:07:57Z
 
dc.date.available2012-10-30T06:07:57Z
 
dc.date.issued2007
 
dc.description.abstractBackground: Right ventricular (RV) volume overload secondary to pulmonary regurgitation contributes to long-term morbidities in patients after tetralogy of Fallot (TOF) repair. We tested the hypothesis that plasma brain natriuretic peptide (BNP) levels relate to RV volume overload, pulmonary regurgitation, and exercise capacity in adolescents after TOF repair. Methods: We assessed the RV function echocardiographically and plasma BNP levels in 32 postoperative TOF patients aged 14.7 ± 3.1 years and 20 age-matched controls. Eighteen patients further underwent cardiovascular magnetic resonance imaging and 26 had exercise testing. Results: Compared with controls, patients had significantly higher BNP levels (p = 0.027), greater indexed RV end-diastolic dimension (p < 0.001), increased RV myocardial performance index (p = 0.005), and reduced tricuspid annular systolic velocity (p = 0.008). Multivariate analysis identified indexed RV end-diastolic dimension as the only significant determinant of plasma BNP levels (β = 0.69, p < 0.001). Plasma BNP levels correlated positively with indexed RV end-diastolic volume (r = 0.6, p = 0.009) and pulmonary regurgitant fraction (r = 0.54, p = 0.026), and negatively with exercise duration (r = - 0.45, p = 0.021), peak oxygen consumption (r = - 0.43, p = 0.03), and minute ventilation at maximal exercise (r = - 0.52, p = 0.006). Multivariate analysis demonstrated BNP levels (β = - 0.43, p = 0.034) and body mass index (β = - 0.40, p = 0.036) to be independent predictors of peak oxygen consumption. No relations were found between BNP levels and RV myocardial performance index, tricuspid annular velocities and RV ejection fraction. Conclusions: In adolescent patients after TOF repair, plasma BNP levels relate to RV volume overload, pulmonary regurgitation and exercise capacity. © 2006 Elsevier Ireland Ltd. All rights reserved.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationInternational Journal Of Cardiology, 2007, v. 121 n. 2, p. 155-162 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.ijcard.2006.10.024
 
dc.identifier.doihttp://dx.doi.org/10.1016/j.ijcard.2006.10.024
 
dc.identifier.epage162
 
dc.identifier.issn0167-5273
2012 Impact Factor: 5.509
2012 SCImago Journal Rankings: 0.788
 
dc.identifier.issue2
 
dc.identifier.pmid17182138
 
dc.identifier.scopuseid_2-s2.0-34548474310
 
dc.identifier.spage155
 
dc.identifier.urihttp://hdl.handle.net/10722/170388
 
dc.identifier.volume121
 
dc.languageeng
 
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ijcard
 
dc.publisher.placeIreland
 
dc.relation.ispartofInternational Journal of Cardiology
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAdolescent
 
dc.subject.meshChild
 
dc.subject.meshCohort Studies
 
dc.subject.meshExercise Test - Methods
 
dc.subject.meshFemale
 
dc.subject.meshHumans
 
dc.subject.meshMale
 
dc.subject.meshNatriuretic Peptide, Brain - Blood
 
dc.subject.meshTetralogy Of Fallot - Blood - Physiopathology - Surgery
 
dc.subject.meshVentricular Dysfunction, Right - Blood - Physiopathology - Surgery
 
dc.subject.meshVentricular Function, Right - Physiology
 
dc.titlePlasma brain natriuretic peptide levels, right ventricular volume overload and exercise capacity in adolescents after surgical repair of tetralogy of Fallot
 
dc.typeArticle
 
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<contributor.author>Cheung, SCW</contributor.author>
<contributor.author>Cheung, Yf</contributor.author>
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Author Affiliations
  1. The University of Hong Kong
  2. Grantham Hospital Hong Kong