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Article: Plasma brain natriuretic peptide levels, right ventricular volume overload and exercise capacity in adolescents after surgical repair of tetralogy of Fallot

TitlePlasma brain natriuretic peptide levels, right ventricular volume overload and exercise capacity in adolescents after surgical repair of tetralogy of Fallot
Authors
Issue Date2007
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ijcard
Citation
International Journal Of Cardiology, 2007, v. 121 n. 2, p. 155-162 How to Cite?
AbstractBackground: Right ventricular (RV) volume overload secondary to pulmonary regurgitation contributes to long-term morbidities in patients after tetralogy of Fallot (TOF) repair. We tested the hypothesis that plasma brain natriuretic peptide (BNP) levels relate to RV volume overload, pulmonary regurgitation, and exercise capacity in adolescents after TOF repair. Methods: We assessed the RV function echocardiographically and plasma BNP levels in 32 postoperative TOF patients aged 14.7 ± 3.1 years and 20 age-matched controls. Eighteen patients further underwent cardiovascular magnetic resonance imaging and 26 had exercise testing. Results: Compared with controls, patients had significantly higher BNP levels (p = 0.027), greater indexed RV end-diastolic dimension (p < 0.001), increased RV myocardial performance index (p = 0.005), and reduced tricuspid annular systolic velocity (p = 0.008). Multivariate analysis identified indexed RV end-diastolic dimension as the only significant determinant of plasma BNP levels (β = 0.69, p < 0.001). Plasma BNP levels correlated positively with indexed RV end-diastolic volume (r = 0.6, p = 0.009) and pulmonary regurgitant fraction (r = 0.54, p = 0.026), and negatively with exercise duration (r = - 0.45, p = 0.021), peak oxygen consumption (r = - 0.43, p = 0.03), and minute ventilation at maximal exercise (r = - 0.52, p = 0.006). Multivariate analysis demonstrated BNP levels (β = - 0.43, p = 0.034) and body mass index (β = - 0.40, p = 0.036) to be independent predictors of peak oxygen consumption. No relations were found between BNP levels and RV myocardial performance index, tricuspid annular velocities and RV ejection fraction. Conclusions: In adolescent patients after TOF repair, plasma BNP levels relate to RV volume overload, pulmonary regurgitation and exercise capacity. © 2006 Elsevier Ireland Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/170388
ISSN
2014 Impact Factor: 4.036
2014 SCImago Journal Rankings: 1.151
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorCheung, EWYen_US
dc.contributor.authorLam, WWMen_US
dc.contributor.authorChiu, CSWen_US
dc.contributor.authorChau, AKTen_US
dc.contributor.authorCheung, SCWen_US
dc.contributor.authorCheung, Yfen_US
dc.date.accessioned2012-10-30T06:07:57Z-
dc.date.available2012-10-30T06:07:57Z-
dc.date.issued2007en_US
dc.identifier.citationInternational Journal Of Cardiology, 2007, v. 121 n. 2, p. 155-162en_US
dc.identifier.issn0167-5273en_US
dc.identifier.urihttp://hdl.handle.net/10722/170388-
dc.description.abstractBackground: Right ventricular (RV) volume overload secondary to pulmonary regurgitation contributes to long-term morbidities in patients after tetralogy of Fallot (TOF) repair. We tested the hypothesis that plasma brain natriuretic peptide (BNP) levels relate to RV volume overload, pulmonary regurgitation, and exercise capacity in adolescents after TOF repair. Methods: We assessed the RV function echocardiographically and plasma BNP levels in 32 postoperative TOF patients aged 14.7 ± 3.1 years and 20 age-matched controls. Eighteen patients further underwent cardiovascular magnetic resonance imaging and 26 had exercise testing. Results: Compared with controls, patients had significantly higher BNP levels (p = 0.027), greater indexed RV end-diastolic dimension (p < 0.001), increased RV myocardial performance index (p = 0.005), and reduced tricuspid annular systolic velocity (p = 0.008). Multivariate analysis identified indexed RV end-diastolic dimension as the only significant determinant of plasma BNP levels (β = 0.69, p < 0.001). Plasma BNP levels correlated positively with indexed RV end-diastolic volume (r = 0.6, p = 0.009) and pulmonary regurgitant fraction (r = 0.54, p = 0.026), and negatively with exercise duration (r = - 0.45, p = 0.021), peak oxygen consumption (r = - 0.43, p = 0.03), and minute ventilation at maximal exercise (r = - 0.52, p = 0.006). Multivariate analysis demonstrated BNP levels (β = - 0.43, p = 0.034) and body mass index (β = - 0.40, p = 0.036) to be independent predictors of peak oxygen consumption. No relations were found between BNP levels and RV myocardial performance index, tricuspid annular velocities and RV ejection fraction. Conclusions: In adolescent patients after TOF repair, plasma BNP levels relate to RV volume overload, pulmonary regurgitation and exercise capacity. © 2006 Elsevier Ireland Ltd. All rights reserved.en_US
dc.languageengen_US
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/ijcarden_US
dc.relation.ispartofInternational Journal of Cardiologyen_US
dc.subject.meshAdolescenten_US
dc.subject.meshChilden_US
dc.subject.meshCohort Studiesen_US
dc.subject.meshExercise Test - Methodsen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshNatriuretic Peptide, Brain - Blooden_US
dc.subject.meshTetralogy Of Fallot - Blood - Physiopathology - Surgeryen_US
dc.subject.meshVentricular Dysfunction, Right - Blood - Physiopathology - Surgeryen_US
dc.subject.meshVentricular Function, Right - Physiologyen_US
dc.titlePlasma brain natriuretic peptide levels, right ventricular volume overload and exercise capacity in adolescents after surgical repair of tetralogy of Falloten_US
dc.typeArticleen_US
dc.identifier.emailCheung, Yf:xfcheung@hku.hken_US
dc.identifier.authorityCheung, Yf=rp00382en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.ijcard.2006.10.024en_US
dc.identifier.pmid17182138en_US
dc.identifier.scopuseid_2-s2.0-34548474310en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34548474310&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume121en_US
dc.identifier.issue2en_US
dc.identifier.spage155en_US
dc.identifier.epage162en_US
dc.identifier.isiWOS:000250558400003-
dc.publisher.placeIrelanden_US
dc.identifier.scopusauthoridCheung, EWY=9432819700en_US
dc.identifier.scopusauthoridLam, WWM=35292558200en_US
dc.identifier.scopusauthoridChiu, CSW=8714554800en_US
dc.identifier.scopusauthoridChau, AKT=35787094400en_US
dc.identifier.scopusauthoridCheung, SCW=17533628600en_US
dc.identifier.scopusauthoridCheung, Yf=7202111067en_US

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