File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Aortic root dilation and aortic elastic properties in children after repair of tetralogy of Fallot

TitleAortic root dilation and aortic elastic properties in children after repair of tetralogy of Fallot
Authors
Issue Date2006
PublisherExcerpta Medica, Inc.. The Journal's web site is located at http://www.ajconline.org/
Citation
American Journal Of Cardiology, 2006, v. 97 n. 6, p. 905-909 How to Cite?
AbstractAnalyses of aortic specimens obtained from patients with tetralogy of Fallot (TOF) revealed elastic fiber fragmentation. This study sought to determine the prevalence of aortic root dilation and aortic regurgitation (AR) in children after TOF repair and tested the hypothesis that aortic elastic properties are altered and related to aortic root dilation in these patients. Aortic dimensions, adjusted for body surface area and expressed as z scores, and AR were assessed echocardiographically in 67 children 8.3 ± 5.6 years after TOF repair. The aortic elastic properties were compared with those in 50 age-matched controls. The prevalence of aortic dilation (z score >2) was 88%, 87%, 61%, and 63% at the annulus, sinus of Valsalva, sinotubular junction, and ascending aorta, respectively. The z scores of the annulus (r = 0.41, p <0.001) and sinus (r = 0.33, p <0.01) were correlated with body surface area. Multivariate analysis identified the duration of follow-up after surgery as the only significant determinant of z scores of the annulus (β = 0.41, p = 0.001) and sinus (β = 0.33, p = 0.009). AR was present in 12% of patients who tended to have larger z scores at all aortic levels. Compared with controls, patients had significantly increased aortic stiffness (p <0.001) and reduced strain (p <0.001) and distensibility (p = 0.002). Aortic stiffness was correlated positively, whereas aortic strain and distensibility were correlated negatively, with the aortic root z scores at all levels. In conclusion, this study shows a high prevalence of aortic root dilation in children after the repair of TOF. Aortic stiffening occurred in these patients and may play a role in progressive aortic root dilation. © 2006 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/170364
ISSN
2015 Impact Factor: 3.154
2015 SCImago Journal Rankings: 2.063
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChong, WYen_US
dc.contributor.authorWong, WHSen_US
dc.contributor.authorChiu, CSWen_US
dc.contributor.authorCheung, YFen_US
dc.date.accessioned2012-10-30T06:07:49Z-
dc.date.available2012-10-30T06:07:49Z-
dc.date.issued2006en_US
dc.identifier.citationAmerican Journal Of Cardiology, 2006, v. 97 n. 6, p. 905-909en_US
dc.identifier.issn0002-9149en_US
dc.identifier.urihttp://hdl.handle.net/10722/170364-
dc.description.abstractAnalyses of aortic specimens obtained from patients with tetralogy of Fallot (TOF) revealed elastic fiber fragmentation. This study sought to determine the prevalence of aortic root dilation and aortic regurgitation (AR) in children after TOF repair and tested the hypothesis that aortic elastic properties are altered and related to aortic root dilation in these patients. Aortic dimensions, adjusted for body surface area and expressed as z scores, and AR were assessed echocardiographically in 67 children 8.3 ± 5.6 years after TOF repair. The aortic elastic properties were compared with those in 50 age-matched controls. The prevalence of aortic dilation (z score >2) was 88%, 87%, 61%, and 63% at the annulus, sinus of Valsalva, sinotubular junction, and ascending aorta, respectively. The z scores of the annulus (r = 0.41, p <0.001) and sinus (r = 0.33, p <0.01) were correlated with body surface area. Multivariate analysis identified the duration of follow-up after surgery as the only significant determinant of z scores of the annulus (β = 0.41, p = 0.001) and sinus (β = 0.33, p = 0.009). AR was present in 12% of patients who tended to have larger z scores at all aortic levels. Compared with controls, patients had significantly increased aortic stiffness (p <0.001) and reduced strain (p <0.001) and distensibility (p = 0.002). Aortic stiffness was correlated positively, whereas aortic strain and distensibility were correlated negatively, with the aortic root z scores at all levels. In conclusion, this study shows a high prevalence of aortic root dilation in children after the repair of TOF. Aortic stiffening occurred in these patients and may play a role in progressive aortic root dilation. © 2006 Elsevier Inc. All rights reserved.en_US
dc.languageengen_US
dc.publisherExcerpta Medica, Inc.. The Journal's web site is located at http://www.ajconline.org/en_US
dc.relation.ispartofAmerican Journal of Cardiologyen_US
dc.subject.meshAorta - Pathology - Physiopathology - Ultrasonographyen_US
dc.subject.meshAortic Valve - Pathology - Physiopathology - Ultrasonographyen_US
dc.subject.meshAortic Valve Insufficiency - Epidemiology - Physiopathology - Ultrasonographyen_US
dc.subject.meshBlood Pressure - Physiologyen_US
dc.subject.meshCase-Control Studiesen_US
dc.subject.meshChilden_US
dc.subject.meshDilatation, Pathologic - Epidemiology - Pathology - Physiopathologyen_US
dc.subject.meshEchocardiographyen_US
dc.subject.meshEchocardiography, Doppler, Coloren_US
dc.subject.meshElasticityen_US
dc.subject.meshFemaleen_US
dc.subject.meshFollow-Up Studiesen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshPrevalenceen_US
dc.subject.meshRegression Analysisen_US
dc.subject.meshTetralogy Of Fallot - Physiopathology - Surgeryen_US
dc.subject.meshTreatment Outcomeen_US
dc.subject.meshTricuspid Valve Insufficiency - Ultrasonographyen_US
dc.titleAortic root dilation and aortic elastic properties in children after repair of tetralogy of Falloten_US
dc.typeArticleen_US
dc.identifier.emailCheung, YF:xfcheung@hku.hken_US
dc.identifier.authorityCheung, YF=rp00382en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.amjcard.2005.09.141en_US
dc.identifier.pmid16516599-
dc.identifier.scopuseid_2-s2.0-33644596427en_US
dc.identifier.hkuros115802-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33644596427&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume97en_US
dc.identifier.issue6en_US
dc.identifier.spage905en_US
dc.identifier.epage909en_US
dc.identifier.isiWOS:000236208700029-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridChong, WY=12760025600en_US
dc.identifier.scopusauthoridWong, WHS=13310222200en_US
dc.identifier.scopusauthoridChiu, CSW=8714554800en_US
dc.identifier.scopusauthoridCheung, YF=7202111067en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats