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Conference Paper: The prognostic and therapeutic potential of AMP-activated protein kinase in ovarian cancer

TitleThe prognostic and therapeutic potential of AMP-activated protein kinase in ovarian cancer
Authors
Issue Date2012
PublisherAsian Society of Gynecologic Oncology (ASGO).
Citation
The ASGO 2nd International Workshop on Gynecologic Oncology, Kyoto, Japan, 28 September 2012. In Conference Program, 2012, p. 32 How to Cite?
AbstractOvarian cancer is one of the leading causes of cancer-associated death in women. The high mortality is due to its poor prognosis as most cases are found in late stages. Therefore, searching reliable tumor markers is urgently needed for clinical management of this disease. Altered cellular metabolism is a crucial phenomenon for the development and progression of ovarian cancer. AMP-activated protein kinase (AMPK) acts as a key intracellular energy sensor and regulator for governing energy balance homeostasis. It also closely links with cancer cell metabolism. Others and we have reported that the activation of AMPK by pharmacological agents shows cytotoxicity to cancer cells, indicating that targeting AMPK could be a promising therapeutic approach. On the other hand, our study also demonstrated that the AMPK activity had an inversely correlation between tumor stage and/or high grade ovarian cancer. Import...
DescriptionTopics3 Translational Research for Ovarian Cancer: no. 3-2
The detailed program is located at http://www.macc.jp/ASGO2ndWS/0913_ASGO2ndWS_Program.pdf
Persistent Identifierhttp://hdl.handle.net/10722/169438

 

DC FieldValueLanguage
dc.contributor.authorChan, DWen_US
dc.contributor.authorNgan, HYSen_US
dc.date.accessioned2012-10-18T08:55:08Z-
dc.date.available2012-10-18T08:55:08Z-
dc.date.issued2012en_US
dc.identifier.citationThe ASGO 2nd International Workshop on Gynecologic Oncology, Kyoto, Japan, 28 September 2012. In Conference Program, 2012, p. 32en_US
dc.identifier.urihttp://hdl.handle.net/10722/169438-
dc.descriptionTopics3 Translational Research for Ovarian Cancer: no. 3-2-
dc.descriptionThe detailed program is located at http://www.macc.jp/ASGO2ndWS/0913_ASGO2ndWS_Program.pdf-
dc.description.abstractOvarian cancer is one of the leading causes of cancer-associated death in women. The high mortality is due to its poor prognosis as most cases are found in late stages. Therefore, searching reliable tumor markers is urgently needed for clinical management of this disease. Altered cellular metabolism is a crucial phenomenon for the development and progression of ovarian cancer. AMP-activated protein kinase (AMPK) acts as a key intracellular energy sensor and regulator for governing energy balance homeostasis. It also closely links with cancer cell metabolism. Others and we have reported that the activation of AMPK by pharmacological agents shows cytotoxicity to cancer cells, indicating that targeting AMPK could be a promising therapeutic approach. On the other hand, our study also demonstrated that the AMPK activity had an inversely correlation between tumor stage and/or high grade ovarian cancer. Import...-
dc.languageengen_US
dc.publisherAsian Society of Gynecologic Oncology (ASGO).-
dc.relation.ispartofASGO 2nd International Workshop on Gynecologic Oncology 2012en_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleThe prognostic and therapeutic potential of AMP-activated protein kinase in ovarian canceren_US
dc.typeConference_Paperen_US
dc.identifier.emailChan, DW: dwchan@hku.hken_US
dc.identifier.emailNgan, HYS: hysngan@hkucc.hku.hken_US
dc.identifier.authorityChan, DW=rp00543en_US
dc.identifier.authorityNgan, HYS=rp00346en_US
dc.description.naturepostprint-
dc.identifier.hkuros212234en_US
dc.identifier.spage32-
dc.identifier.epage32-

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