Conference Paper: Downregulation of ASPP2 in choriocarcinoma contributes to increased migratory potential through Src activation

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TitleDownregulation of ASPP2 in choriocarcinoma contributes to increased migratory potential through Src activation
AuthorsMak, VCY
Lee, L
Siu, MKY
Wong, OGW
Lu, X
Ngan, HYS
Wong, ESY
Cheung, ANY
Issue Date2011
PublisherAmerican Association for Cancer Research.
CitationThe 102nd Annual Meeting of the American Association for Cancer Research (AACR 2011), Orlando, FL., 2-6 April 2011. [How to Cite?]
AbstractGestational choriocarcinoma is a malignant tumour derived from placental trophoblast and is the most aggressive member of gestational trophoblastic disease (GTD). Apoptotic stimulating protein of p53-2 (ASPP2) is a tumor suppressor member of the ASPP family which transactivates p53-dependent apoptotic pathway. In this study, we examined the expression profile of ASPP2 in choriocarcinoma in comparison with normal placentas and hydatidiform moles which is a type of GTD that carries malignant potential. Results from quantitative PCR and immunohistochemical studies showed that downregulation of ASPP2 was detected in ...
DescriptionPoster Session 7 - Signaling Pathways Involved in Oncogenesis and Tumor Suppression: abstract no. 2107
DC Field
Value
dc.contributor.authorMak, VCY
dc.contributor.authorLee, L
dc.contributor.authorSiu, MKY
dc.contributor.authorWong, OGW
dc.contributor.authorLu, X
dc.contributor.authorNgan, HYS
dc.contributor.authorWong, ESY
dc.contributor.authorCheung, ANY
dc.date.accessioned2012-10-18T08:52:10Z
dc.date.available2012-10-18T08:52:10Z
dc.date.issued2011
dc.description.abstractGestational choriocarcinoma is a malignant tumour derived from placental trophoblast and is the most aggressive member of gestational trophoblastic disease (GTD). Apoptotic stimulating protein of p53-2 (ASPP2) is a tumor suppressor member of the ASPP family which transactivates p53-dependent apoptotic pathway. In this study, we examined the expression profile of ASPP2 in choriocarcinoma in comparison with normal placentas and hydatidiform moles which is a type of GTD that carries malignant potential. Results from quantitative PCR and immunohistochemical studies showed that downregulation of ASPP2 was detected in ...
dc.description.naturelink_to_OA_fulltext
dc.descriptionPoster Session 7 - Signaling Pathways Involved in Oncogenesis and Tumor Suppression: abstract no. 2107
dc.description.otherThe 102nd Annual Meeting of the American Association for Cancer Research (AACR 2011), Orlando, FL., 2-6 April 2011.
dc.identifier.citationThe 102nd Annual Meeting of the American Association for Cancer Research (AACR 2011), Orlando, FL., 2-6 April 2011. [How to Cite?]
dc.identifier.hkuros212024
dc.identifier.urihttp://hdl.handle.net/10722/169374
dc.languageeng
dc.publisherAmerican Association for Cancer Research.
dc.publisher.placeUnited States
dc.relation.ispartofAnnual Meeting of the American Association for Cancer Research, AACR 2011
dc.titleDownregulation of ASPP2 in choriocarcinoma contributes to increased migratory potential through Src activation
dc.typeConference_Paper