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Conference Paper: Dissolved oxygen sensing using organometallic dyes deposited within a microfluidic environment
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TitleDissolved oxygen sensing using organometallic dyes deposited within a microfluidic environment
 
AuthorsChen, QL2
Ho, HP2
Jin, L2
Chu, BWK1
Li, MJ1
Yam, VWW1
 
KeywordsCovalent Attachment
Microfluidics
Oxygen Sensing
 
Issue Date2008
 
PublisherS P I E - International Society for Optical Engineering. The Journal's web site is located at http://spie.org/x1848.xml
 
CitationProceedings Of Spie - The International Society For Optical Engineering, 2008, v. 6886 [How to Cite?]
DOI: http://dx.doi.org/10.1117/12.762666
 
AbstractThis work primarily aims to integrate dissolved oxygen sensing capability with a microfluidic platform containing arrays of micro bio-reactors or bio-activity indicators. The measurement of oxygen concentration is of significance for a variety of bio-related applications such as cell culture and gene expression. Optical oxygen sensors based on luminescence quenching are gaining much interest in light of their low power consumption, quick response and high analyte sensitivity in comparison to similar oxygen sensing devices. In our microfluidic oxygen sensor device, a thin layer of oxygen-sensitive luminescent organometallic dye is covalently bonded to a glass slide. Micro flow channels are formed on the glass slide using patterned PDMS (Polydimethylsiloxane). Dissolved oxygen sensing is then performed by directing an optical excitation probe beam to the area of interest within the microfluidic channel. The covalent bonding approach for sensor layer formation offers many distinct advantages over the physical entrapment method including minimizing dye leaching, ensuring good stability and fabrication simplicity. Experimental results confirm the feasibility of the device.
 
ISSN0277-786X
2013 SCImago Journal Rankings: 0.203
 
DOIhttp://dx.doi.org/10.1117/12.762666
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorChen, QL
 
dc.contributor.authorHo, HP
 
dc.contributor.authorJin, L
 
dc.contributor.authorChu, BWK
 
dc.contributor.authorLi, MJ
 
dc.contributor.authorYam, VWW
 
dc.date.accessioned2012-10-08T03:34:57Z
 
dc.date.available2012-10-08T03:34:57Z
 
dc.date.issued2008
 
dc.description.abstractThis work primarily aims to integrate dissolved oxygen sensing capability with a microfluidic platform containing arrays of micro bio-reactors or bio-activity indicators. The measurement of oxygen concentration is of significance for a variety of bio-related applications such as cell culture and gene expression. Optical oxygen sensors based on luminescence quenching are gaining much interest in light of their low power consumption, quick response and high analyte sensitivity in comparison to similar oxygen sensing devices. In our microfluidic oxygen sensor device, a thin layer of oxygen-sensitive luminescent organometallic dye is covalently bonded to a glass slide. Micro flow channels are formed on the glass slide using patterned PDMS (Polydimethylsiloxane). Dissolved oxygen sensing is then performed by directing an optical excitation probe beam to the area of interest within the microfluidic channel. The covalent bonding approach for sensor layer formation offers many distinct advantages over the physical entrapment method including minimizing dye leaching, ensuring good stability and fabrication simplicity. Experimental results confirm the feasibility of the device.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationProceedings Of Spie - The International Society For Optical Engineering, 2008, v. 6886 [How to Cite?]
DOI: http://dx.doi.org/10.1117/12.762666
 
dc.identifier.doihttp://dx.doi.org/10.1117/12.762666
 
dc.identifier.issn0277-786X
2013 SCImago Journal Rankings: 0.203
 
dc.identifier.scopuseid_2-s2.0-41149102859
 
dc.identifier.urihttp://hdl.handle.net/10722/168842
 
dc.identifier.volume6886
 
dc.languageeng
 
dc.publisherS P I E - International Society for Optical Engineering. The Journal's web site is located at http://spie.org/x1848.xml
 
dc.publisher.placeUnited States
 
dc.relation.ispartofProceedings of SPIE - The International Society for Optical Engineering
 
dc.relation.referencesReferences in Scopus
 
dc.subjectCovalent Attachment
 
dc.subjectMicrofluidics
 
dc.subjectOxygen Sensing
 
dc.titleDissolved oxygen sensing using organometallic dyes deposited within a microfluidic environment
 
dc.typeConference_Paper
 
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<contributor.author>Ho, HP</contributor.author>
<contributor.author>Jin, L</contributor.author>
<contributor.author>Chu, BWK</contributor.author>
<contributor.author>Li, MJ</contributor.author>
<contributor.author>Yam, VWW</contributor.author>
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Author Affiliations
  1. Institute of Molecular Technology for Drug Discovery and Synthesis, Hong Kong
  2. Chinese University of Hong Kong