Conference Paper: Dissolved oxygen sensing using organometallic dyes deposited within a microfluidic environment

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Publisher Website: 10.1117/12.762666
Scopus: eid_2-s2.0-41149102859

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Title	Dissolved oxygen sensing using organometallic dyes deposited within a microfluidic environment
Authors	Chen, QL2 Ho, HP2 Jin, L2 Chu, BWK1 Li, MJ1 Yam, VWW1
Keywords	Covalent Attachment Microfluidics Oxygen Sensing
Issue Date	2008
Publisher	S P I E - International Society for Optical Engineering. The Journal's web site is located at http://spie.org/x1848.xml
Citation	Proceedings Of Spie - The International Society For Optical Engineering, 2008, v. 6886 [How to Cite?] DOI: http://dx.doi.org/10.1117/12.762666
Abstract	This work primarily aims to integrate dissolved oxygen sensing capability with a microfluidic platform containing arrays of micro bio-reactors or bio-activity indicators. The measurement of oxygen concentration is of significance for a variety of bio-related applications such as cell culture and gene expression. Optical oxygen sensors based on luminescence quenching are gaining much interest in light of their low power consumption, quick response and high analyte sensitivity in comparison to similar oxygen sensing devices. In our microfluidic oxygen sensor device, a thin layer of oxygen-sensitive luminescent organometallic dye is covalently bonded to a glass slide. Micro flow channels are formed on the glass slide using patterned PDMS (Polydimethylsiloxane). Dissolved oxygen sensing is then performed by directing an optical excitation probe beam to the area of interest within the microfluidic channel. The covalent bonding approach for sensor layer formation offers many distinct advantages over the physical entrapment method including minimizing dye leaching, ensuring good stability and fabrication simplicity. Experimental results confirm the feasibility of the device.
ISSN	0277-786X 2011 SCImago Journal Rankings: 0.046
DOI	http://dx.doi.org/10.1117/12.762666
References	References in Scopus

DC Field	Value
dc.contributor.author	Chen, QL
dc.contributor.author	Ho, HP
dc.contributor.author	Jin, L
dc.contributor.author	Chu, BWK
dc.contributor.author	Li, MJ
dc.contributor.author	Yam, VWW
dc.date.accessioned	2012-10-08T03:34:57Z
dc.date.available	2012-10-08T03:34:57Z
dc.date.issued	2008
dc.description.abstract	This work primarily aims to integrate dissolved oxygen sensing capability with a microfluidic platform containing arrays of micro bio-reactors or bio-activity indicators. The measurement of oxygen concentration is of significance for a variety of bio-related applications such as cell culture and gene expression. Optical oxygen sensors based on luminescence quenching are gaining much interest in light of their low power consumption, quick response and high analyte sensitivity in comparison to similar oxygen sensing devices. In our microfluidic oxygen sensor device, a thin layer of oxygen-sensitive luminescent organometallic dye is covalently bonded to a glass slide. Micro flow channels are formed on the glass slide using patterned PDMS (Polydimethylsiloxane). Dissolved oxygen sensing is then performed by directing an optical excitation probe beam to the area of interest within the microfluidic channel. The covalent bonding approach for sensor layer formation offers many distinct advantages over the physical entrapment method including minimizing dye leaching, ensuring good stability and fabrication simplicity. Experimental results confirm the feasibility of the device.
dc.description.nature	Link_to_subscribed_fulltext
dc.identifier.citation	Proceedings Of Spie - The International Society For Optical Engineering, 2008, v. 6886 [How to Cite?] DOI: http://dx.doi.org/10.1117/12.762666
dc.identifier.doi	http://dx.doi.org/10.1117/12.762666
dc.identifier.issn	0277-786X 2011 SCImago Journal Rankings: 0.046
dc.identifier.scopus	eid_2-s2.0-41149102859
dc.identifier.uri	http://hdl.handle.net/10722/168842
dc.identifier.volume	6886
dc.language	eng
dc.publisher	S P I E - International Society for Optical Engineering. The Journal's web site is located at http://spie.org/x1848.xml
dc.publisher.place	United States
dc.relation.ispartof	Proceedings of SPIE - The International Society for Optical Engineering
dc.relation.references	References in Scopus
dc.subject	Covalent Attachment
dc.subject	Microfluidics
dc.subject	Oxygen Sensing
dc.title	Dissolved oxygen sensing using organometallic dyes deposited within a microfluidic environment
dc.type	Conference_Paper

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Author Affiliations

Institute of Molecular Technology for Drug Discovery and Synthesis, Hong Kong
Chinese University of Hong Kong

Conference Paper: Dissolved oxygen sensing using organometallic dyes deposited within a microfluidic environment

The HKU Scholars Hub has contact details for these author(s).