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Article: Involvement of protein kinase C in reduction of aggregated protein and phosphorylation of CREB in glomeruli

TitleInvolvement of protein kinase C in reduction of aggregated protein and phosphorylation of CREB in glomeruli
Authors
Issue Date2012
PublisherJapanese Association for Laboratory Animal Science. The Journal's web site is located at http://expanim.jstage.jst.go.jp/ja/
Citation
Experimental Animals, 2012, v. 61 n. 2, p. 119-124 How to Cite?
AbstractWe previously demonstrated the cAMP-PKA pathway to be associated with the reduction in aggregated proteins such as immune complex in glomeruli. The aim of this study was to clarify whether PKC is involved in the reduction of aggregated protein and phosphorylation of CREB in aggregated protein-loaded glomeruli. Mice were injected with aggregated bovine serum albumin (a-BSA), and glomeruli were isolated. The a-BSA-injected mice produced more cyclic AMP and had more phosphorylated serine and phosphorylated CREB in their glomeruli than the controls. The expression of phospho-CREB increased with the accumulation of a-BSA. KT5720 and H7 suppressed the increase in phosphorylated CREB in a-BSA-loaded glomeruli and the decrease in accumulated a-BSA in the glomeruli. These findings suggest that PKC is associated with the reduction of aggregated protein and phosphorylation of CREB in aggregated protein-loaded glomeruli. © 2012 Japanese Association for Laboratory Animal Science.
Persistent Identifierhttp://hdl.handle.net/10722/166085
ISSN
2015 Impact Factor: 1.247
2015 SCImago Journal Rankings: 0.542
References

 

DC FieldValueLanguage
dc.contributor.authorHirasawa, Yen_HK
dc.contributor.authorNishiyama, Ten_HK
dc.contributor.authorNagao, Ten_HK
dc.contributor.authorFeng, Yen_HK
dc.contributor.authorNagamatsu, Ten_HK
dc.date.accessioned2012-09-20T08:27:57Z-
dc.date.available2012-09-20T08:27:57Z-
dc.date.issued2012en_HK
dc.identifier.citationExperimental Animals, 2012, v. 61 n. 2, p. 119-124en_HK
dc.identifier.issn1341-1357en_HK
dc.identifier.urihttp://hdl.handle.net/10722/166085-
dc.description.abstractWe previously demonstrated the cAMP-PKA pathway to be associated with the reduction in aggregated proteins such as immune complex in glomeruli. The aim of this study was to clarify whether PKC is involved in the reduction of aggregated protein and phosphorylation of CREB in aggregated protein-loaded glomeruli. Mice were injected with aggregated bovine serum albumin (a-BSA), and glomeruli were isolated. The a-BSA-injected mice produced more cyclic AMP and had more phosphorylated serine and phosphorylated CREB in their glomeruli than the controls. The expression of phospho-CREB increased with the accumulation of a-BSA. KT5720 and H7 suppressed the increase in phosphorylated CREB in a-BSA-loaded glomeruli and the decrease in accumulated a-BSA in the glomeruli. These findings suggest that PKC is associated with the reduction of aggregated protein and phosphorylation of CREB in aggregated protein-loaded glomeruli. © 2012 Japanese Association for Laboratory Animal Science.en_HK
dc.languageengen_US
dc.publisherJapanese Association for Laboratory Animal Science. The Journal's web site is located at http://expanim.jstage.jst.go.jp/ja/en_HK
dc.relation.ispartofExperimental Animalsen_HK
dc.subject.mesh1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine - pharmacologyen_HK
dc.subject.meshAnimalsen_HK
dc.subject.meshCREB-Binding Protein - metabolismen_HK
dc.subject.meshCarbazoles - pharmacologyen_HK
dc.subject.meshCattleen_HK
dc.subject.meshCyclic AMP - metabolismen_HK
dc.subject.meshEnzyme Inhibitors - pharmacologyen_HK
dc.subject.meshKidney Glomerulus - drug effects - metabolismen_HK
dc.subject.meshMaleen_HK
dc.subject.meshMiceen_HK
dc.subject.meshMice, Inbred ICRen_HK
dc.subject.meshOxidative Phosphorylationen_HK
dc.subject.meshProtein Kinase C - antagonists & inhibitors - metabolismen_HK
dc.subject.meshPyrroles - pharmacologyen_HK
dc.subject.meshSerum Albumin, Bovine - metabolism - pharmacologyen_HK
dc.titleInvolvement of protein kinase C in reduction of aggregated protein and phosphorylation of CREB in glomerulien_HK
dc.typeArticleen_HK
dc.identifier.emailFeng, Y: yfeng@hku.hken_HK
dc.identifier.authorityFeng, Y=rp00466en_HK
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1538/expanim.61.119en_HK
dc.identifier.pmid22531726-
dc.identifier.scopuseid_2-s2.0-84861466227en_HK
dc.identifier.hkuros208634en_US
dc.identifier.hkuros217181-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84861466227&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume61en_HK
dc.identifier.issue2en_HK
dc.identifier.spage119en_HK
dc.identifier.epage124en_HK
dc.publisher.placeJapanen_HK
dc.identifier.scopusauthoridHirasawa, Y=7102854698en_HK
dc.identifier.scopusauthoridNishiyama, T=36890043600en_HK
dc.identifier.scopusauthoridNagao, T=7401489558en_HK
dc.identifier.scopusauthoridFeng, Y=24467969600en_HK
dc.identifier.scopusauthoridNagamatsu, T=55228530000en_HK

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