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Conference Paper: Acute phase circulating micoRNAs predict tumor recurrence and survivals of hepatocellular carcinoma patients after liver transplantation

TitleAcute phase circulating micoRNAs predict tumor recurrence and survivals of hepatocellular carcinoma patients after liver transplantation
Authors
KeywordsMedical sciences
Gastroenterology medical sciences
Surgery
Issue Date2012
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jtoc/106570021
Citation
The 18th Annual International Congress of the ILTS, San Francisco, 16-19 May 2012. In Liver Transplantation, 2012, v. 18 suppl. s1, p. S124-S125, abstract no. O-128 How to Cite?
AbstractBACKGROUND AND AIM: Tumor recurrence remains a critical issue in liver transplantation for hepatocelluar carcinoma (HCC) patients especially using living donor graft. However, there is a lack of effective prognostic biomarker. We aim to identify acute phase circulating microRNAs (miRNAs), stable molecules in blood, for predicting tumor recurrence and survivals of HCC patients after liver transplantation. METHODS: miRNA-array analysis was performed to compare the plasma miRNA profiles at 2-hour post-transplantation between HCC patients with and without tumor recurrence after liver transplantation. Differential microRNAs were validated by TaqMan real-time RT-PCR among 62 HCC patients at 2-hour post-transplantation and 12 healthy donors. Youden index for predicting tumor recurrence after liver transplantation was determined to classify Low- and High-expression groups for suitable miRNAs. The prognostic values of plasma miRNAs for predicting tumor recurrence and overall and progression-free survivals of patients were examined by statistical analysis. RESULT: Identified by miRNA-array analysis, 14 plasma miRNAs were significantly up-regulated in HCC patients with tumor recurrence after liver transplantation. Statistical analysis of 62 HCC patients showed that high level of plasma mir151-5p (p=0.012), mir215 (p=0.016), mir1246 (p=0.012) or mir1290 (p=0.031) was significantly correlated with tumor recurrence after liver transplantation. Kaplan Meier analysis showed that high level of plasma mir27b (p=0.04), mir122 (p=0.032), mir151-5p (p=0.015), mir192 (p=0.027) or mir1246 (p=0.009) was significantly associated with poor overall survival of patients and high level of mir122 (p=0.028), mir151-5p (p=0.001), mir192(p=0.047) or mir1246 (p=0.001) was significantly associated with progression-free survival. Univariable Cox proportional hazard regression analysis showed that mir151-5p and mir1246 were significant prognostic markers of overall survival (p=0.032 and p=0.024) and progression-free survival (p=0.006 and p=0.005) of HCC patients after liver transplantation. Mir1246 was predicted to target genes involved in tumor suppression, chromatin remodeling, cell cycle and growth. CONCLUSION: Acute phase plasma mir151-5p and mir1246 are potential circulating biomarkers for predicting tumor recurrence and overall and progression-free survivals of HCC patients after liver transplantation.
DescriptionThis journal supplement contain abstracts of the ILTS 18th Annual International Congress
Concurrent Session: Recurrent Disease/Pathology
Among Young Investigator Award Winners: KTP Ng
Persistent Identifierhttp://hdl.handle.net/10722/165634
ISSN
2015 Impact Factor: 3.951
2015 SCImago Journal Rankings: 1.763

 

DC FieldValueLanguage
dc.contributor.authorNg, KTPen_US
dc.contributor.authorMan, Ken_US
dc.contributor.authorWong, Nen_US
dc.contributor.authorLi, CXen_US
dc.contributor.authorChan, SCen_US
dc.contributor.authorLo, CMen_US
dc.date.accessioned2012-09-20T08:21:36Z-
dc.date.available2012-09-20T08:21:36Z-
dc.date.issued2012en_US
dc.identifier.citationThe 18th Annual International Congress of the ILTS, San Francisco, 16-19 May 2012. In Liver Transplantation, 2012, v. 18 suppl. s1, p. S124-S125, abstract no. O-128en_US
dc.identifier.issn1527-6465-
dc.identifier.urihttp://hdl.handle.net/10722/165634-
dc.descriptionThis journal supplement contain abstracts of the ILTS 18th Annual International Congress-
dc.descriptionConcurrent Session: Recurrent Disease/Pathology-
dc.descriptionAmong Young Investigator Award Winners: KTP Ng-
dc.description.abstractBACKGROUND AND AIM: Tumor recurrence remains a critical issue in liver transplantation for hepatocelluar carcinoma (HCC) patients especially using living donor graft. However, there is a lack of effective prognostic biomarker. We aim to identify acute phase circulating microRNAs (miRNAs), stable molecules in blood, for predicting tumor recurrence and survivals of HCC patients after liver transplantation. METHODS: miRNA-array analysis was performed to compare the plasma miRNA profiles at 2-hour post-transplantation between HCC patients with and without tumor recurrence after liver transplantation. Differential microRNAs were validated by TaqMan real-time RT-PCR among 62 HCC patients at 2-hour post-transplantation and 12 healthy donors. Youden index for predicting tumor recurrence after liver transplantation was determined to classify Low- and High-expression groups for suitable miRNAs. The prognostic values of plasma miRNAs for predicting tumor recurrence and overall and progression-free survivals of patients were examined by statistical analysis. RESULT: Identified by miRNA-array analysis, 14 plasma miRNAs were significantly up-regulated in HCC patients with tumor recurrence after liver transplantation. Statistical analysis of 62 HCC patients showed that high level of plasma mir151-5p (p=0.012), mir215 (p=0.016), mir1246 (p=0.012) or mir1290 (p=0.031) was significantly correlated with tumor recurrence after liver transplantation. Kaplan Meier analysis showed that high level of plasma mir27b (p=0.04), mir122 (p=0.032), mir151-5p (p=0.015), mir192 (p=0.027) or mir1246 (p=0.009) was significantly associated with poor overall survival of patients and high level of mir122 (p=0.028), mir151-5p (p=0.001), mir192(p=0.047) or mir1246 (p=0.001) was significantly associated with progression-free survival. Univariable Cox proportional hazard regression analysis showed that mir151-5p and mir1246 were significant prognostic markers of overall survival (p=0.032 and p=0.024) and progression-free survival (p=0.006 and p=0.005) of HCC patients after liver transplantation. Mir1246 was predicted to target genes involved in tumor suppression, chromatin remodeling, cell cycle and growth. CONCLUSION: Acute phase plasma mir151-5p and mir1246 are potential circulating biomarkers for predicting tumor recurrence and overall and progression-free survivals of HCC patients after liver transplantation.-
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jtoc/106570021-
dc.relation.ispartofLiver Transplantationen_US
dc.rightsLiver Transplantation. Copyright © John Wiley & Sons, Inc.-
dc.subjectMedical sciences-
dc.subjectGastroenterology medical sciences-
dc.subjectSurgery-
dc.titleAcute phase circulating micoRNAs predict tumor recurrence and survivals of hepatocellular carcinoma patients after liver transplantationen_US
dc.typeConference_Paperen_US
dc.identifier.emailNg, KTP: ledodes@hku.hken_US
dc.identifier.emailMan, K: kwanman@hku.hken_US
dc.identifier.emailLi, CX: doclicx@hku.hken_US
dc.identifier.emailChan, SC: chanlsc@hkucc.hku.hken_US
dc.identifier.emailLo, CM: chungmlo@hkucc.hku.hken_US
dc.identifier.authorityNg, KTP=rp01720en_US
dc.identifier.authorityMan, K=rp00417en_US
dc.identifier.authorityChan, SC=rp01568en_US
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1002/lt.23435-
dc.identifier.hkuros206130en_US
dc.identifier.volume18-
dc.identifier.issuesuppl. s1-
dc.identifier.spageS124-
dc.identifier.epageS125-
dc.publisher.placeUnited States-
dc.customcontrol.immutablesml 130524-

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